4.6 Review

Human γδ T Cell Subsets and Their Clinical Applications for Cancer Immunotherapy

Journal

CANCERS
Volume 14, Issue 12, Pages -

Publisher

MDPI
DOI: 10.3390/cancers14123005

Keywords

gamma delta T (gamma delta T) cells; cancer immunotherapy; chimeric antigen receptor T (CAR-T) cells; allogeneic cell therapy; butyrophilins (BTN); zoledronate (ZOL)

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Funding

  1. California Institute for Regenerative Medicine [TRAN1-12250]
  2. UCLA BSCRC Innovation Award
  3. Ablon Scholars Award
  4. T32 Microbial Pathogenesis Training Grant (Ruth L. Kirschstein National Research Service Award) [T32-AI007323]

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γδ (gamma delta) T cells are a minor population of T cells with both innate and adaptive immune properties. They can be activated independently of MHC, making them ideal for immunotherapy development. Gene editing technologies can enhance the antitumor functions of different subsets of γδ T cells.
Gamma delta (gamma delta) T cells are a minor population of T cells that share adaptive and innate immune properties. In contrast to MHC-restricted alpha beta (alpha beta) T cells, gamma delta T cells are activated in an MHC-independent manner, making them ideal candidates for developing allogeneic, off-the-shelf cell-based immunotherapies. As the field of cancer immunotherapy progresses rapidly, different subsets of gamma delta T cells have been explored. In addition, gamma delta T cells can be engineered using different gene editing technologies that augment their tumor recognition abilities and antitumor functions. In this review, we outline the unique features of different subsets of human gamma delta T cells and their antitumor properties. We also summarize the past and the ongoing pre-clinical studies and clinical trials utilizing gamma delta T cell-based cancer immunotherapy.

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