In the quest for treating alcohol liver disease

Article Medicine, General & Internal

Liver alterations are not improved by inulin supplementation in alcohol use disorder patients during alcohol withdrawal: A pilot randomized, double-blind, placebo-controlled study

Camille Amadieu et al.

Summary: This study aimed to evaluate the effects of inulin supplementation on liver parameters in alcohol use disorder (AUD) patients. The results showed that, at the end of the study, AST, ALT, and IL-18 levels were significantly higher in the inulin group compared to the placebo group in the whole sample. In the subgroup with early alcohol-associated liver disease, inulin supplementation led to specific changes in the gut microbiota, but AST and ALT levels were still higher compared to the placebo group. The treatment was well tolerated without important adverse events or side effects.

EBIOMEDICINE (2022)

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Article Gastroenterology & Hepatology

A Randomized Clinical Trial of Fecal Microbiota Transplant for Alcohol Use Disorder

Jasmohan S. Bajaj et al.

Summary: This study suggests that FMT may be a safe and effective treatment for patients with alcohol-related cirrhosis, reducing alcohol craving and consumption while improving cognition and quality of life.

HEPATOLOGY (2021)

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Article Gastroenterology & Hepatology

Microbiota tryptophan metabolism induces aryl hydrocarbon receptor activation and improves alcohol-induced liver injury

Laura Wrzosek et al.

Summary: This study demonstrates that targeting the intestinal microbiota can improve alcoholic liver disease, with a key role played by the aryl hydrocarbon receptor (AhR) pathway.

GUT (2021)

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Review Infectious Diseases