4.8 Article

RASER MRI: Magnetic resonance images formed spontaneously exploiting cooperative nonlinear interaction

Journal

SCIENCE ADVANCES
Volume 8, Issue 28, Pages -

Publisher

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/sciadv.abp8483

Keywords

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Funding

  1. Department of Defense CDMRP [W81XWH-20-10576]
  2. National Heart, Lung, and Blood Institute [1 R21 HL154032-01]
  3. National Science Foundation [CHE-1904780]
  4. National Institute of Biomedical Imaging and Bioengineering [1R01EB029829]
  5. Office of Biological and Environmental Research of the U.S. Department of Energy Atmospheric System Research Program Interagency [DE-SC0000001]
  6. National Institute of Health [R21-EB025313, R01EB029829]
  7. KIT-Publication Fund of the Karlsruhe Institute of Technology

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This study demonstrates a different contrast mechanism in MRI by establishing RASER in imaged media. RASER can generate stronger image contrast than conventional MRI by utilizing small local differences in initial population inversion density.
The spatial resolution of magnetic resonance imaging (MRI) is limited by the width of Lorentzian point spread functions associated with the transverse relaxation rate 1/T-2*. Here, we show a different contrast mechanism in MRI by establishing RASER (radio-frequency amplification by stimulated emission of radiation) in imaged media. RASER imaging bursts emerge out of noise and without applying radio-frequency pulses when placing spins with sufficient population inversion in a weak magnetic field gradient. Small local differences in initial population inversion density can create stronger image contrast than conventional MRI. This different contrast mechanism is based on the cooperative nonlinear interaction between all slices. On the other hand, the cooperative nonlinear interaction gives rise to imaging artifacts, such as amplitude distortions and side lobes outside of the imaging domain. Contrast mechanism and artifacts are explored experimentally and predicted by simulations on the basis of a proposed RASER MRI theory.

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