4.6 Review

Log-Rank Test vs MaxCombo and Difference in Restricted Mean Survival Time Tests for Comparing Survival Under Nonproportional Hazards in Immuno-oncology Trials A Systematic Review and Meta-analysis

Related references

Note: Only part of the references are listed.
Article Mathematical & Computational Biology

Robust Design and Analysis of Clinical Trials With Nonproportional Hazards: A Straw Man Guidance From a Cross-Pharma Working Group

Satrajit Roychoudhury et al.

Summary: Loss of power and clear description of treatment differences are important issues in clinical trial design and analysis, especially in nonproportional hazard scenarios. The current ICH E9 (R1) addendum suggests designing trials with clinically relevant estimands, while a combination test proposed by a cross-pharma working group provides robust power under different alternative hypotheses.

STATISTICS IN BIOPHARMACEUTICAL RESEARCH (2023)

Article Mathematical & Computational Biology

Nonproportional Hazards-An Evaluation of the MaxCombo Test in Cancer Clinical Trials

Yuan-Li Shen et al.

Summary: This study evaluated the performance of the MaxCombo test in assessing treatment differences. The interpretation of the test results was found to be challenging, especially when the Kaplan-Meier curves crossed or showed early separation.

STATISTICS IN BIOPHARMACEUTICAL RESEARCH (2023)

Article Mathematical & Computational Biology

Alternative Analysis Methods for Time to Event Endpoints Under Nonproportional Hazards: A Comparative Analysis

Ray S. Lin et al.

STATISTICS IN BIOPHARMACEUTICAL RESEARCH (2020)

Article Pharmacology & Pharmacy

Statistical and practical considerations in designing of immuno-oncology trials

Pralay Mukhopadhyay et al.

JOURNAL OF BIOPHARMACEUTICAL STATISTICS (2020)

Article Medicine, General & Internal

Atezolizumab for First-Line Treatment of PD-L1-Selected Patients with NSCLC

Roy S. Herbst et al.

NEW ENGLAND JOURNAL OF MEDICINE (2020)

Article Medicine, General & Internal

Nivolumab for Recurrent Squamous-Cell Carcinoma of the Head and Neck

R. L. Ferris et al.

NEW ENGLAND JOURNAL OF MEDICINE (2016)

Article Biology

Untitled

BIOMETRICS (2016)

Article Medicine, General & Internal

Nivolumab in Previously Untreated Melanoma without BRAF Mutation

Caroline Robert et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab and Ipilimumab versus Ipilimumab in Untreated Melanoma

Michael A. Postow et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab versus Docetaxel in Advanced Nonsquamous Non-Small-Cell Lung Cancer

H. Borghaei et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

R. J. Motzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Medicine, General & Internal

Combined Nivolumab and Ipilimumab or Monotherapy in Untreated Melanoma

J. Larkin et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Article Health Care Sciences & Services

Enhanced secondary analysis of survival data: reconstructing the data from published Kaplan-Meier survival curves

Patricia Guyot et al.

BMC MEDICAL RESEARCH METHODOLOGY (2012)

Article Medicine, General & Internal

Sipuleucel-T Immunotherapy for Castration-Resistant Prostate Cancer.

Philip W. Kantoff et al.

NEW ENGLAND JOURNAL OF MEDICINE (2010)

Article Mathematical & Computational Biology

Generalized pairwise comparisons of prioritized outcomes in the two-sample problem

Marc Buyse

STATISTICS IN MEDICINE (2010)

Article Medicine, General & Internal

Gefitinib or Carboplatin-Paclitaxel in Pulmonary Adenocarcinoma.

Tony S. Mok et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)