Journal
CHEMISTRYSELECT
Volume 7, Issue 25, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202200954
Keywords
Bio-based solvent Eucalyptol; Indoles; Michael addition; alpha,beta-Unsaturated Ketones
Categories
Funding
- DST-SERB [EEQ/2017/000764]
- Department of Science Technology, India
- CUG Gandhinagar
- DST Govt of India
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By using reusable and low toxic eucalyptol as a green solvent, and Fe(OTs)(3)center dot 6H(2)O as green catalyst for the Michael addition reaction of indoles to alpha,beta-unsaturated ketones and nitrostyrene, the methodology offers broad substrate scope and excellent yields (up to 90%) in short reaction times.
Reduction of carbon footprint generated by organic solvents via replacing them with greener solvents is of great interest in recent times. Herein, we report a Michael addition reaction of indoles to alpha,beta-unsaturated ketones, and nitrostyrene using reusable and low toxic eucalyptol as a green solvent, and Fe(OTs)(3)center dot 6H(2)O as green catalyst. This methodology offers broad substrate scope and excellent yields (up to 90%) in short reaction times.
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