Journal
CHEMISTRYSELECT
Volume 7, Issue 30, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/slct.202201135
Keywords
iridium; dehydrogenation; dehydration; alcohols
Categories
Funding
- JSPS KAKENHI [JP18H05517, JP19H02715, JP22H02075]
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Esters and ethers are commonly used compounds in modern organic synthesis. The dehydrogenative coupling of primary alcohols for ester synthesis has recently been proposed as an environmentally friendly process. In this study, a new catalytic function switching system was successfully developed using a single iridium catalyst, enabling both dehydrogenative esterification and dehydrative etherification under environmentally friendly conditions.
Esters and ethers are widely used in modern organic synthesis. In recent years, the synthesis of esters by the dehydrogenative coupling of primary alcohols has been reported to be an environmentally benign process. In this situations, if a single catalyst can be used for the synthesis of either esters or ethers by making slight alterations to the reaction conditions, the value of the synthetic methodology would increase. In this study, we successfully developed a new catalytic function switching system: not only dehydrogenative esterification but also dehydrative etherification under environmentally friendly conditions were accomplished by the employment of a single iridium catalyst based on catalytic function switching. Using benzyl alcohol as a starting material, the esterification product, benzyl benzoate, and the etherification product, dibenzyl ether, were obtained in 92 % and 89 % yields, respectively, by employing same iridium catalyst precursor bearing a dihydroxybipyridine ligand, under optimized conditions.
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