Journal
CHEMNANOMAT
Volume 8, Issue 10, Pages -Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/cnma.202200205
Keywords
MOFs; AIPH; Photothermal therapy; Oxygen-independent PDT; Synergistic therapy
Categories
Funding
- Natural Science Foundation of China [21975072, 51902106, 52103314]
- Chenguang Plan of Shanghai Education Development Foundation [21CGA38]
- Natural Science Foundation of Shanghai [18ZR1408700]
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In this study, a near-infrared triggered photothermal therapy and oxygen-independent photodynamic therapy system based on metal-organic frameworks was developed for cancer treatment. The combination of different substances achieved effective apoptosis of cancer cells through NIR-triggered synergistic therapy.
Due to the limited penetration depth of visible light and insufficient oxygen supply in hypoxic tumor tissues, the development of near-infrared (NIR) triggered and oxygen-independent photodynamic therapy (PDT) to generate active radicals is necessary for cancer treatment. Herein, we developed a NIR-triggered photothermal therapy (PTT) and oxygen-independent PDT system based on metal-organic frameworks (MOFs), which integrated indocyanine green (ICG) and 2,2'-azobis[2-(2-imidazolin-2-yl)propane] dihydrochloride (AIPH) as NIR-triggered photothermal units and temperature-sensitive free radical initiator into ZIF-8, respectively. AIPH was introduced into ZIF-8 via a one-pot strategy with high loading capacity (125 mg g(-1)). Through the irradiation of 808 nm laser, the ICG units could efficiently absorb NIR light to rapidly raise the local temperature to 44 degrees C within 3 minutes. Meanwhile, the local high temperature further induced the AIPH to continuously generate toxic alkyl radicals (R-C center dot). The combination of PTT and free radical therapy is significantly better than the single treatment mode. More importantly, the NIR-triggered synergistic therapy could induce extensive apoptosis of cancer cells in hypoxic conditions, which sheds new light on the development of MOFs-based photochemical therapy platform in the actual tumor microenvironment.
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