Journal
FRONTIERS IN PSYCHIATRY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fpsyt.2022.923938
Keywords
transcranial direct current stimulation (tDCS); Schizophrenia; auditory verbal hallucinations; resting-state functional connectivity; machine learning; treatment response
Categories
Funding
- Department of Science and Technology, Government of India [DST/SJF/LSA02/2014-15]
- La Foundation Grant [IN-2018-002]
- IBM Alberta Centre for Advanced Studies funds
- Simon and Martina Sochatsky Fund for Mental Health
- University Hospital Foundation
- Alberta Machine Intelligence Institute
- NSERC
- Alberta Innovates Graduate Student Scholarship
- Department of Biotechnology (DBT)-Wellcome Trust India Alliance [IA/CRC/19/1/610005, IA/CPHE/19/1/504591, IA/CPHE/18/1/503956, IA/CPHI/16/1/502662]
- Nurturing Clinical Scientist Scheme of the Indian Council of Medical Research
- Department of Biotechnology, Government of India [BT/HRD-NBANWB/38/2019-20 (6)]
Ask authors/readers for more resources
This study examines the feasibility of using resting-state functional connectivity (rs-FC) to predict treatment response to transcranial direct current stimulation (tDCS) in patients with schizophrenia and persistent auditory verbal hallucinations (AVH). The results show that the functional connectivity between different brain regions can differentiate responders from non-responders, and a machine learning model based on this can accurately predict the clinical response.
Transcranial direct current stimulation (tDCS) is a promising adjuvant treatment for persistent auditory verbal hallucinations (AVH) in Schizophrenia (SZ). Nonetheless, there is considerable inter-patient variability in the treatment response of AVH to tDCS in SZ. Machine-learned models have the potential to predict clinical response to tDCS in SZ. This study aims to examine the feasibility of identifying SZ patients with persistent AVH (SZ-AVH) who will respond to tDCS based on resting-state functional connectivity (rs-FC). Thirty-four SZ-AVH patients underwent resting-state functional MRI at baseline followed by add-on, twice-daily, 20-min sessions with tDCS (conventional/high-definition) for 5 days. A machine learning model was developed to identify tDCS treatment responders based on the rs-FC pattern, using the left superior temporal gyrus (LSTG) as the seed region. Functional connectivity between LSTG and brain regions involved in auditory and sensorimotor processing emerged as the important predictors of the tDCS treatment response. L1-regularized logistic regression model had an overall accuracy of 72.5% in classifying responders vs. non-responders. This model outperformed the state-of-the-art convolutional neural networks (CNN) model-both without (59.41%) and with pre-training (68.82%). It also outperformed the L1-logistic regression model trained with baseline demographic features and clinical scores of SZ patients. This study reports the first evidence that rs-fMRI-derived brain connectivity pattern can predict the clinical response of persistent AVH to add-on tDCS in SZ patients with 72.5% accuracy.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available