Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.913373
Keywords
Latent Autoimmune Diabetes in Adults; LADA; Metabolic Syndrome; MetS; Obesity; Insulin Resistance; type 2 diabetes mellitus; type 1 diabetes mellitus
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Funding
- Four batches Innovation Plan Project of Developing Medicine Through Science and Technology of Shanxi Provincial Health and Wellness Committee [2020XM25]
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This review discusses the prevalence of MetS in LADA and the risk and role of insulin resistance in the development of LADA from the perspectives of inflammatory factors, environmental factors, and the gut microbiota, aiming to improve our understanding of this condition.
Latent autoimmune diabetes in adults (LADA) is a heterogeneous subtype of diabetes characterized by islet cell destruction mediated by islet autoimmunity and insulin resistance. Metabolic syndrome (MetS) is a state in which many risk factors for metabolic and cardiovascular diseases accumulate in an individual. Based on clinical data, this review covers the prevalence of MetS in LADA, focusing on the risk associated with and the role of insulin resistance in the development of LADA from the perspective of inflammatory factors, environmental factors, and the gut microbiota, aiming to improve our understanding of this condition.
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