Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.922825
Keywords
primary cilium; insulin-degrading enzyme; pancreas; beta-cell; alpha-cell; insulin signaling; insulin; proliferation
Categories
Funding
- La Caixa Foundation - MCIN/AEI [LCF/PR/PR18/51130007, PID2019-110496RB-C21, PID2019110496RB-C22, MCIN/AEI/10.13039/501100011033]
- European Foundation for the Study of Diabetes Rising Star Fellowship - EFSDNovo Nordisk
- Programa Estrategico Instituto de Biologia y Genetica Molecular (IBGM), Junta de Castilla y Leon [CCVC8485]
- Junta de Castilla y Leon [ORDER EDU/574/2018]
- European Social Fund [ORDER EDU/556/2019]
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The primary cilium is a cell organelle located at the cell surface, which plays a role in sensing external stimuli and mediating cell-to-cell communication. Recent studies have uncovered the emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic beta- and alpha-cell functions and glucose homeostasis.
The primary cilium is a narrow organelle located at the surface of the cell in contact with the extracellular environment. Once underappreciated, now is thought to efficiently sense external environmental cues and mediate cell-to-cell communication, because many receptors, ion channels, and signaling molecules are highly or differentially expressed in primary cilium. Rare genetic disorders that affect cilia integrity and function, such as Bardet-Biedl syndrome and Alstrom syndrome, have awoken interest in studying the biology of cilium. In this review, we discuss recent evidence suggesting emerging roles of primary cilium and cilia-mediated signaling pathways in the regulation of pancreatic beta- and alpha-cell functions, and its implications in regulating glucose homeostasis.
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