Journal
FRONTIERS IN ENDOCRINOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fendo.2022.924589
Keywords
acromegaly; adenoma; pituitary; endonasal; endoscopic; skull-base; transnasal
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Funding
- Nell W. and William S. Elkin Research Fellowship in Oncology, Winship Cancer Institute, Emory University Hospital, Atlanta, GA
- National Center for Advancing Translational Sciences of the National Institutes of Health [UL1TR002378, TL1TR002382]
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Acromegaly is a disease caused by excessive levels of growth hormone, usually due to hormone-secreting pituitary adenomas, leading to adverse effects in multiple systems. Diagnosis involves measuring serum growth hormone and IGF-1 levels and obtaining an MRI to evaluate pituitary adenoma function. Complete surgical resection of the growth hormone-secreting adenoma is the preferred treatment for acromegaly, aiming for biochemical remission. Medical and radiation therapies are available if biochemical cure is not achieved after surgery.
Acromegaly is a disease that occurs secondary to high levels of GH, most often from a hormone-secreting pituitary adenoma, with multisystem adverse effects. Diagnosis includes serum GH and IGF-1 levels, and obtaining an MRI pituitary protocol to assess for a functional pituitary adenoma. Attempted gross total resection of the GH-secreting adenoma is the gold standard in treatment for patients with acromegaly for a goal of biochemical remission. Medical and radiation therapies are available when patients do not achieve biochemical cure after surgical therapy.
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