Related references
Note: Only part of the references are listed.
Review
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Summary: The prenatal period is critical for human development, and the foetus is particularly vulnerable to environmental factors. Maternal nutrition plays a significant role in the offspring's health, with imbalanced metabolic status potentially leading to metabolic disorders. Animal studies and human research have shown the influence of maternal diet on offspring development, but the mechanisms linking impaired foetal development and adult diseases are still not fully understood.
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Summary: It is well documented that the environment during fetal development and postnatal period can significantly influence adult phenotype, age-related traits, and risk of chronic disease. Researchers have found that early life hormonal interventions, such as growth hormone replacement therapy, can impact the trajectory of aging and adult metabolic characteristics in mice. Important regulatory mechanisms involving epigenetic phenomena are likely involved.
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Summary: Excess maternal energy intake leads to long-term disorders in offspring's brown adipose tissue (BAT), affecting blood lipid panel and BAT structure. It also influences the methylation levels and expression of genes involved in thermogenesis and fatty acid oxidation in BAT.
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Brittany B. Rice et al.
Summary: This study investigated the effects of PCB exposure on glucose tolerance and body composition in offspring expressing or lacking Nrf2, finding that PCB exposure during nursing led to reduced body weight and impaired glucose disposal. The study also revealed that the presence or absence of Nrf2 did not significantly impact the metabolic responses of offspring to in utero PCB exposure. Future research will focus on understanding the influence of maternal Nrf2 genotypic differences on offspring metabolic responses.
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