Journal
FRONTIERS IN GENETICS
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fgene.2022.948496
Keywords
xenotransplantation; skeletal muscle function; human animal chimeras; somatic cell nuclear transfer; blastocyst complementation
Categories
Funding
- Department of Defense [12975087]
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Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights the potential and impact of using gene edited pigs as a novel treatment platform.
Focusing on complex extremity trauma and volumetric muscle loss (VML) injuries, this review highlights: 1) the current pathophysiologic limitations of the injury sequela; 2) the gene editing strategy of the pig as a model that provides a novel treatment approach; 3) the notion that human skeletal muscle derived from gene edited, humanized pigs provides a groundbreaking treatment option; and 4) the impact of this technologic platform and how it will advance to far more multifaceted applications. This review seeks to shed insights on a novel treatment option using gene edited pigs as a platform which is necessary to overcome the clinical challenges and limitations in the field.
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