Journal
FRONTIERS IN CHEMISTRY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2022.930297
Keywords
isoliquiritigenin; sulfobutyl ether-beta-cyclodextrin; inclusion complex; preparation; characterization
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Funding
- Department of Education of Guangdong Province [333 2019KZDXM035, 2021ZDZX4041, 2021KTSCX135, 2021KCXTD044]
- Jiangmen City Science and Technology Basic Research Project [2020030101030005457]
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In this study, an inclusion complex of ISL with SBE-beta-CD was successfully prepared, improving the water solubility and antioxidant activities of ISL and enhancing its stability in biological environments.
Isoliquiritigenin (ISL) possesses a wide variety of pharmacological properties, however, its poor solubility and oral bioavailability pose a significant barrier to its application. In present studies, the ISL inclusion complex was prepared with sulfobutyl ether-beta-cyclodextrin (SBE-beta-CD). The physicochemical characterizations of ISL-SBE-beta-CD were performed with Fourier transform infrared (FT-IR) spectroscopy and X-ray powder diffraction (XRD). Phase solubility study suggested a 1:1 formation of ISL-SBE-beta-CD complexes. The water solubility of ISL rose from 13.6 mu M to 4.05 mM by the inclusion of SBE-beta-CD. The antioxidant activities (IC50) of ISL-SBE-beta-CD reached 42.2 mu g/ml, which was significantly lower than that of ISL (60.5 mu g/ml). Its stability in biological environments was also enhanced.
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