Journal
FRONTIERS IN CHEMISTRY
Volume 10, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fchem.2022.963004
Keywords
liposome; nano-carrier; targeted-delivery; natural product; traditional Chinese medicine
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Funding
- Standardized Construction of Chinese Medicine Rehabilitation Service [2019GJZGJ01-01]
- Zhejiang Provincial Administration of Traditional Chinese Medicine [2020ZB131]
- Nanjing Tech University [38274017101, 3827401742]
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This review discusses the targeted delivery of medicinal natural products, focusing on the preparation of functional liposomes and the application of liposomal medicinal natural products. It provides useful guidance to enhance targeted therapy of medicinal natural products.
Although medicinal natural products and their derivatives have shown promising effects in disease therapies, they usually suffer the drawbacks in low solubility and stability in the physiological environment, low delivery efficiency, side effects due to multi-targeting, and low site-specific distribution in the lesion. In this review, targeted delivery was well-guided by liposomal formulation in the aspects of preparation of functional liposomes, liposomal medicinal natural products, combined therapies, and image-guided therapy. This review is believed to provide useful guidance to enhance the targeted therapy of medicinal natural products and their derivatives.
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