Journal
PREGNANCY HYPERTENSION-AN INTERNATIONAL JOURNAL OF WOMENS CARDIOVASCULAR HEALTH
Volume 29, Issue -, Pages 14-20Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.preghy.2022.05.008
Keywords
Nitric Oxide; Nitrosylation; NOS; Endothelial cells; S-nitrosothiols; SNOs; Endothelial dysfunction; Preeclampsia
Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2017/07570-8, 2018/24484-0, 2019/07230-8, 2020/14610-9]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [308504/2021-6, 431720/2018-5, 305091/2021-2]
- National Institutes of Health (NIH) [R01HL148191, U54GM115428]
Ask authors/readers for more resources
S-nitrosylation is a process in which nitric oxide reacts with free thiol groups in proteins, modulating cellular functions and acting as a mediator in endothelial cells. Deficits in NO bioavailability have been associated with pregnancy-related disorders. Studying the role of S-nitrosylation in preeclampsia can provide insights into its pathophysiology and potential drug treatments.
The formation of S-nitrosothiols (SNOs) occurs with the reaction of nitric oxide (NO) and free thiol groups in proteins. This process, called S-nitrosylation, allows NO to interfere with or even modulate a variety of cellular functions, culminating with the modification of protein trafficking, redox state, and cell cycle. Furthermore, NO plays a role in modulating a wide range of functions in endothelial cells specifically, including inflammation, apoptosis, permeability, migration, and cell growth. As such, NO acts as a mediator in several physiological processes. The interaction between endothelial nitric oxide synthase (eNOS) and proteins that are to be targeted for S-nitrosylation is a key determinant of the specificity of NO signaling. Deficits in the bioavailability of NO have been associated with pregnancy-related disorders, such as preeclampsia (PE). The study of S-nitrosylation in PE, as well as the identification of targeted proteins, may contribute to a better understanding of its pathophysiology and the development of drugs for the treatment of PE patients. In this review, we aimed to present the mechanism of S-nitrosylation, the regulatory pathways, and some proteins by which S-nitrosylation can modulate NO availability with a potential impact on PE.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available