4.5 Article

Corticosteroid Responsiveness Following Mepolizumab in Severe Eosinophilic Asthma-A Randomized, Placebo-Controlled Crossover Trial (MAPLE)

Related references

Note: Only part of the references are listed.
Review Allergy

Exploring the origin and regulatory role of mast cells in asthma

Ryan C. Murphy et al.

Summary: Recent studies have shed light on the central role of mast cells in regulating lower airway inflammation and airway hyperresponsiveness.

CURRENT OPINION IN ALLERGY AND CLINICAL IMMUNOLOGY (2021)

Article Critical Care Medicine

Eosinophilic and Noneosinophilic Asthma An Expert Consensus Framework to Characterize Phenotypes in a Global Real-Life Severe Asthma Cohort

Liam G. Heaney et al.

Summary: By analyzing patients with severe asthma from 11 countries globally, this study found the prevalence of eosinophilic and noneosinophilic asthma phenotypes, as well as the differences in characteristics between the two phenotypes, providing important insights for personalized treatment.

CHEST (2021)

Article Critical Care Medicine

The inflammatory profile of exacerbations in patients with severe refractory eosinophilic asthma receiving mepolizumab (the MEX study): a prospective observational study

P. Jane McDowell et al.

Summary: This study investigated the inflammatory phenotype and physiological characteristics of exacerbation events in patients with severe eosinophilic asthma treated with mepolizumab. The results showed that exacerbations on mepolizumab could be divided into non-eosinophilic events and eosinophilic events, which could be differentiated using FeNO as a marker. This challenges the routine use of oral corticosteroids for all asthma exacerbation events on mepolizumab, and emphasizes the importance of profiling the inflammatory phenotype for better management.

LANCET RESPIRATORY MEDICINE (2021)

Article Critical Care Medicine

Baseline FeNO as a prognostic biomarker for subsequent severe asthma exacerbations in patients with uncontrolled, moderate-to-severe asthma receiving placebo in the LIBERTY ASTHMA QUEST study: a post-hoc analysis

William W. Busse et al.

Summary: In this study, higher baseline FeNO levels were associated with greater risk of severe asthma exacerbations in patients with uncontrolled, moderate-to-severe asthma, especially when combined with elevated eosinophil count and prior exacerbations, supporting the added value of FeNO as a prognostic biomarker. Further research is needed to confirm FeNO as an independent predictor for asthma exacerbations.

LANCET RESPIRATORY MEDICINE (2021)

Article Allergy

Variability of Type 2 inflammatory markers guiding biologic therapy of severe asthma: A 5-year retrospective study from a single tertiary hospital

Hongwen Li et al.

Summary: The study revealed individual distributions and variable patterns of T2 inflammatory markers in patients with severe asthma, offering guidance for the application of biologic therapies. Comprehensive multiple assessments of T2 inflammatory markers support personalized biologic therapy for patients with severe asthma based on their biomarker levels.

WORLD ALLERGY ORGANIZATION JOURNAL (2021)

Review Critical Care Medicine

Systematic Literature Review of Systemic Corticosteroid Use for Asthma Management

Eugene R. Bleecker et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

Review Respiratory System

How can we minimise the use of regular oral corticosteroids in asthma?

Arnaud Bourdin et al.

EUROPEAN RESPIRATORY REVIEW (2020)

Article Allergy

Stratification of asthma phenotypes by airway proteomic signatures

James P. R. Schofield et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

Article Medicine, General & Internal

Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma

M. Castro et al.

NEW ENGLAND JOURNAL OF MEDICINE (2018)

Editorial Material Respiratory System

Asthma and corticosteroids: time for a more precise approach to treatment

Eleanor M. Dunican et al.

EUROPEAN RESPIRATORY JOURNAL (2017)

Article Medicine, General & Internal

KIT Inhibition by Imatinib in Patients with Severe Refractory Asthma

Katherine N. Cahill et al.

NEW ENGLAND JOURNAL OF MEDICINE (2017)

Editorial Material Critical Care Medicine

Mepolizumab, quality of life, and severe eosinophilic asthma

Ian D. Pavord

LANCET RESPIRATORY MEDICINE (2017)

Article Critical Care Medicine

Effects of Age and Disease Severity on Systemic Corticosteroid Responses in Asthma

Wanda Phipatanakul et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2017)

Article Medicine, General & Internal

Oral Glucocorticoid-Sparing Effect of Mepolizumab in Eosinophilic Asthma

Elisabeth H. Bel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Medicine, General & Internal

Mepolizumab Treatment in Patients with Severe Eosinophilic Asthma

Hector G. Ortega et al.

NEW ENGLAND JOURNAL OF MEDICINE (2014)

Article Pharmacology & Pharmacy

A recommended analysis for 2 x 2 crossover trials with baseline measurements

Devan V. Mehrotra

PHARMACEUTICAL STATISTICS (2014)

Editorial Material Biochemistry & Molecular Biology

Eosinophilic airway inflammation in nonallergic asthma

Guy G. Brusselle et al.

NATURE MEDICINE (2013)

Review Cardiac & Cardiovascular Systems

Exhaled nitric oxide to predict corticosteroid responsiveness and reduce asthma exacerbation rates

James F. Donohue et al.

RESPIRATORY MEDICINE (2013)

Article Cardiac & Cardiovascular Systems

Phenotypic predictors of response to oral glucocorticosteroids in severe asthma

Maciej Kupczyk et al.

RESPIRATORY MEDICINE (2013)

Article Critical Care Medicine

An Official ATS Clinical Practice Guideline: Interpretation of Exhaled Nitric Oxide Levels (FENO) for Clinical Applications

Raed A. Dweik et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2011)

Article Allergy

Effects of oral prednisone on sputum eosinophils and cytokines in patients with severe refractory asthma

Federico L. Dente et al.

ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY (2010)

Article Medicine, General & Internal

Mepolizumab and Exacerbations of Refractory Eosinophilic Asthma

Pranabashis Haldar et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

Article Respiratory System

Economic burden of asthma: a systematic review

Katayoun Bahadori et al.

BMC Pulmonary Medicine (2009)

Article Critical Care Medicine

Refractory eosinophilic airway inflammation in severe asthma - Effect of parenteral corticosteroids

A ten Brinke et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2004)

Article Respiratory System

Monoclonal anti-interleukin-5 treatment suppresses eosinophil but not T-cell functions

C Büttner et al.

EUROPEAN RESPIRATORY JOURNAL (2003)