Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.876029
Keywords
innate lymphoid cells; ILC2; adipose tissue; metabolism; cytokines; intestine
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Funding
- Japan Society for the Promotion of Science [21H03388, 20H00511]
- FRIPRO Mobility Grant Fellowship from the Research Council of Norway [302241]
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ILC2s are tissue-resident immune cells that exist not only in adipose tissue but also in various other tissues such as lung and skin. They can change their functions or distribution depending on the environment and circumstances. This review outlines the recent understanding of ILC2 biology and discusses future directions for ILC2 research, particularly in adipose tissue and metabolic homeostasis.
Group 2 innate lymphoid cells (ILC2s) were initially identified as a new type of lymphocytes that produce vigorous amounts of type 2 cytokines in adipose tissue. Subsequent studies revealed that ILC2s are present not only in adipose tissue but also in various other tissues such as lung and skin. ILC2s are generally recognized as tissue-resident immune cells that regulate tissue homeostasis. ILC2s express receptors for various humoral factors and thus can change their functions or distribution depending on the environment and circumstances. In this review, we will outline our recent understanding of ILC2 biology and discuss future directions for ILC2 research, particularly in adipose tissue and metabolic homeostasis.
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