Immunotherapy: Reshape the Tumor Immune Microenvironment

Tumor immune microenvironment (TIME) include tumor cells, immune cells, cytokines, etc. The interactions between these components, which are divided into anti-tumor and pro-tumor, determine the trend of anti-tumor immunity. Although the immune system can eliminate tumor through the cancer-immune cycle, tumors appear to eventually evade from immune surveillance by shaping an immunosuppressive microenvironment. Immunotherapy reshapes the TIME and restores the tumor killing ability of anti-tumor immune cells. Herein, we review the function of immune cells within the TIME and discuss the contribution of current mainstream immunotherapeutic approaches to remolding the TIME. Changes in the immune microenvironment in different forms under the intervention of immunotherapy can shed light on better combination treatment strategies.

Automated summary

This article reviews the function of immune cells within the tumor immune microenvironment (TIME) and discusses the contribution of current mainstream immunotherapeutic approaches to remodeling the TIME. Immunotherapy can restore the tumor killing ability of anti-tumor immune cells and shed light on better combination treatment strategies.