Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.906192
Keywords
Tenebrio molitor; Imd pathway; innate immunity; antimicrobial peptides; cross-regulation
Categories
Funding
- National Research Foundation of Korea (NRF) - Ministry of Science, ICT and future Planning [2019R1I1A3A01057848]
- Korea Institute of Planning and Evaluation for Technology in Food, Agriculture and Forestry (IPET) - Ministry of Agriculture, Food and Rural Affairs (MAFRA) [321055-05]
- National Research Foundation of Korea [2019R1I1A3A01057848] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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This review provides an overview of the importance of studying the immune system of the yellow mealworm and the critical role of the Imd signaling pathway in its humoral immune response. However, the nature and mechanism of the molecules involved in the signal cascade of the Imd pathway in T. molitor are still not fully understood.
Yellow mealworm (Tenebrio molitor) is a highly beneficial beetle that serves as an excellent source of edible protein as well as a practical study model. Therefore, studying its immune system is important. Like in other insects, the innate immune response effected through antimicrobial peptides production provides the most critical defense armory in T. molitor. Immune deficiency (Imd) signaling is one of the major pathways involved in the humoral innate immune response in this beetle. However, the nature of the molecules involved in the signaling cascade of the Imd pathway, from recognition to the production of final effectors, and their mechanism of action are yet to be elucidated in T. molitor model. In this review, we present a general overview of the current literature available on the Imd signaling pathway and its identified interaction partners in T. molitor.
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