☆ 4.8 Review

Epigenetic regulation and T-cell responses in endometriosis - something other than autoimmunity

FRONTIERS IN IMMUNOLOGY (2022)

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LncRNA Expression Profiles in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Emerging Biomarkers and Therapeutic Targets

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Antigen-Specific Regulatory T Cell Therapy in Autoimmune Diseases and Transplantation

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Summary: Regulatory T (Treg) cells are a diverse population of immunosuppressive T cells with therapeutic potential for treating autoimmune diseases and graft rejection. Antigen-specific Treg cells have shown to be more effective in disease-specific regulation, but face challenges such as the identification of disease-relevant antigens and the stability of cells post-transfer.

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Novel Insights into Epigenetic Regulation of IL6 Pathway: In Silico Perspective on Inflammation and Cancer Relationship

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Summary: Abnormal activation of the IL-6 pathway contributes to tumor cell growth and immune system inhibition in various cancers. Computational analysis on TCGA datasets revealed that the expression of IL6, IL6R, IL6ST, and their transmembrane isoforms is regulated by DNA methylation, microRNAs, and post-translational modifications. Furthermore, epigenetic modulation of these genes impacts the survival rate of cancer patients, suggesting potential prognostic and therapeutic value in clinical settings.

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Local states of chromatin compaction at transcription start sites control transcription levels

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Summary: The 'open' and 'compact' regions of chromatin are implicated in active and silent transcription, respectively. However, this study suggests that transcription output is not only determined by the open-compact conversion of chromatin, but also by structural variations within chromatin itself. It was found that chromatin compaction plays a crucial role in transcription levels, with local states of chromatin compaction determining gene expression.

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Concomitant autoimmunity may be a predictor of more severe stages of endometriosis

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Summary: The study suggests that women with endometriosis who also have autoimmune diseases are more likely to develop severe stage IV endometriosis, even after controlling for relevant confounders. The presence of autoimmune disturbances was found to be a significant predictor of the severity of endometriosis.

SCIENTIFIC REPORTS (2021)

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Endometrial stem/progenitor cells and their roles in immunity, clinical application, and endometriosis

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Summary: Endometrial stem/progenitor cells play crucial roles in cell therapy, immune regulation, and endometriosis, with MenSCs being ideal candidates for their abundant sources and autotransplantation capabilities. Limited BMDSCs in blood circulation can lead to the establishment of deep invasive endometriosis.

STEM CELL RESEARCH & THERAPY (2021)

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Single-cell transcriptomic analysis of endometriosis provides insights into fibroblast fates and immune cell heterogeneity

Junyan Ma et al.

Summary: The study identified fibroblast subpopulations associated with endometriosis development, with StAR playing an important role in this process. Immune cells in endometriosis showed varying levels of activation, and cell-cell interaction analyses highlighted an imbalanced immune environment.

CELL AND BIOSCIENCE (2021)

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Small-Molecule Inhibitors Overcome Epigenetic Reprogramming for Cancer Therapy

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Summary: Cancer treatment remains a significant challenge globally, with epigenetic modification being identified as a key target for drug development. By adding chemical groups to the DNA backbone and modifying chromatin architecture through various enzymes, epigenetic drugs have shown promising effects in both preclinical and clinical studies. Developing small-molecule inhibitors targeting epigenetic modified enzymes has become a focus for future cancer therapy research.

FRONTIERS IN PHARMACOLOGY (2021)

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CD8+ Regulatory T Cell - A Mystery to Be Revealed

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Summary: Regulatory T cells, specifically CD8(+) Tregs, are crucial in maintaining immune balance and preventing autoimmune disorders. The subsets of CD8(+) Tregs, such as CD122(hi)Ly49(+)CD8(+) Tregs, have been identified as non-redundant regulators of germinal center reaction, dependent on factors like Helios, IL-15, TGF-beta, and Eomesodermin. Further research is needed to fully understand the differentiation, function, and true identity of CD8(+) Tregs compared to CD4(+) follicular regulatory T cells in controlling germinal center reaction.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Transient Depletion of Foxp3+ Regulatory T Cells Selectively Promotes Aggressive β Cell Autoimmunity in Genetically Susceptible DEREG Mice

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Summary: In NOD mice, transient loss of Foxp3(+) Treg cells is sufficient to induce severe insulitis and persistent hyperglycemia. This highlights the vital role of Foxp3(+) Treg cell activity in controlling autoimmune diabetes.

FRONTIERS IN IMMUNOLOGY (2021)

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Summary: The study reveals that Notch1 transcriptional complexes directly activate Rag1 and Rag2 genes, with a novel cis-element SPS playing an important role in T-ALL and DN cells.

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Summary: Endometriosis is a common chronic inflammatory condition characterized by endometrial tissue appearing outside the uterine cavity, affecting up to 15% of reproductive aged women. The etiopathogenesis of endometrial lesions remains unclear, but dysfunction of stem cells is suspected to play a significant role in their formation. Excess estrogen exposure and progesterone resistance in the endometrial/endometriotic tissue are crucial, and targeting MSCs and EnSCs for epigenetic therapies may hold promise for prevention and treatment.

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Temporal Dynamics of Reactive Oxygen and Nitrogen Species and NF-κB Activation During Acute and Chronic T Cell-Driven Inflammation

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BIOLOGY OF REPRODUCTION (2020)

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Genetic Variation in Type 1 Diabetes Reconfigures the 3D Chromatin Organization of T Cells and Alters Gene Expression

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IMMUNITY (2020)

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Control of regulatory T-cell differentiation and function by T-cell receptor signalling and Foxp3 transcription factor complexes

Masahiro Ono

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The Fate of Th17 Cells is Shaped by Epigenetic Modifications and Remodeled by the Tumor Microenvironment

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A comparative view on vitamin C effects on αβ- versus γδ T-cell activation and differentiation

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Advances in the role of helper T cells in autoimmune diseases

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Emerging Roles for Noncoding RNAs in Autoimmune Thyroid Disease

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Non-coding RNAs in Rheumatoid Arthritis: From Bench to Bedside

Jinghua Wang et al.

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Molecular Mechanisms Controlling Foxp3 Expression in Health and Autoimmunity: From Epigenetic to Post-translational Regulation

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Estrogen Receptors and Endometriosis

Elodie Chantalat et al.

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Regulation of Inflammation Pathways and Inflammasome by Sex Steroid Hormones in Endometriosis

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Increasing Prevalence of Antinuclear Antibodies in the United States

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Epigenetic Regulation of Key Enzymes CYP7a1 and HMGCR Affect Hepatic Cholesterol Metabolism in Different Breeds of Piglets

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Soluble immune checkpoints CTLA-4, HLA-G, PD-1, and PD-L1 are associated with endometriosis-related infertility

Budi Santoso et al.

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Role of Regulatory T Cells in Regulating Fetal-Maternal Immune Tolerance in Healthy Pregnancies and Reproductive Diseases

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Perspectives on the Role of Non-Coding RNAs in the Regulation of Expression and Function of the Estrogen Receptor

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Role of Non-coding RNAs in the Pathogenesis of Endometriosis

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Exploring the Role of Non-Coding RNAs in the Pathophysiology of Systemic Lupus Erythematosus

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Regulatory T Cell Metabolism in Atherosclerosis

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Higher frequency of circulating, but not tissue regulatory T cells in patients with endometriosis

Ali-Akbar Delbandi et al.

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Epigenetics of Estrogen and Progesterone Receptors in Endometriosis

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Rewriting History: Epigenetic Reprogramming of CD8+T Cell Differentiation to Enhance Immunotherapy

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A decade of immune-checkpoint inhibitors in cancer therapy

Caroline Robert

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Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle

Wanxin Wang et al.

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G Protein-Coupled Estrogen Receptor in Immune Cells and Its Role in Immune-Related Diseases

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The Methyltransferase DOT1L Controls Activation and Lineage Integrity in CD4+ T Cells during Infection and Inflammation

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Platelets and Regulatory T Cells May Induce a Type 2 Immunity That Is Conducive to the Progression and Fibrogenesis of Endometriosis

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Regulatory T Cells in Angiogenesis

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Long Non-Coding RNA Associated with Cholesterol Homeostasis and Its Involvement in Metabolic Diseases

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MiR-26b-3p regulates osteoblast differentiation via targeting estrogen receptor α

Yu Lin et al.

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Transcriptional and epigenetic regulation of immune tolerance: roles of the NF-κB family members

Lei Zhang et al.

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The Emerging Role of In Vitro-Transcribed mRNA in Adoptive T Cell Immunotherapy

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The emerging role of epigenetics in human autoimmune disorders

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Estrogen receptor α in T cells suppresses follicular helper T cell responses and prevents autoimmunity

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Differential Levels of Regulatory T Cells and T-Helper-17 Cells in Women With Early and Advanced Endometriosis

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Treg cells in autoimmunity: from identification to Treg-based therapies

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The association between endometriosis and autoimmune diseases: a systematic review and meta-analysis

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How does the immune system learn to distinguish between good and evil? The first definitive studies of T cell central tolerance and positive selection

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TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity

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The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights

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GATA6 expression promoted by an active enhancer may become a molecular marker in endometriosis lesions

Masao Izawa et al.

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CD33+CD14+CD11b+HLA-DR- monocytic myeloid-derived suppressor cells recruited and activated by CCR9/CCL25 are crucial for the pathogenic progression of endometriosis

Ya Sun et al.

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Progesterone modulates the T-cell response via glucocorticoid receptor-dependent pathways

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Pathogenesis of endometriosis: the genetic/epigenetic theory

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FERTILITY AND STERILITY (2019)

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Endometriosis and cancer

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FREE RADICAL BIOLOGY AND MEDICINE (2019)

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Expression of programmed death-1 (PD-1) and its ligand PD-L1 is upregulated in endometriosis and promoted by 17beta-estradiol

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Thymus machinery for T-cell selection

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Long noncoding RNAs in autoimmune diseases

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JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A (2019)

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The timeline of epigenetic drug discovery: from reality to dreams

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Potential Implications of Long Noncoding RNAs in Autoimmune Diseases

Keun Hur et al.

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T cell receptor signaling for γδT cell development

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INFLAMMATION AND REGENERATION (2019)

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Epigenomics-Guided Drug Development: Recent Advances in Solving the Cancer Treatment jigsaw puzzle

Kevin Dzobo

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Posttranscriptional regulation of lipid metabolism by non-coding RNAs and RNA binding proteins

Abhishek K. Singh et al.

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Pathogenesis of endometriosis: Interaction between Endocrine and inflammatory pathways

Bansari G. Patel et al.

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Immunology of endometriosis

Luiza da Gama Coelho Riccio et al.

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Endometriosis and infertility: Insights into the causal link and management strategies

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Risk for and consequences of endometriosis: A critical epidemiologic review

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Emerging role of lncRNAs in systemic lupus erythematosus

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Metazoan MicroRNAs

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MicroRNA as Crucial Regulators of Gene Expression in Estradiol-Treated Human Endothelial Cells

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Reactive Oxygen Species in Metabolic and Inflammatory Signaling

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Spontaneous endometriosis in cynomolgus monkeys as a clinically relevant experimental model

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A cellular and molecular view of T helper 17 cell plasticity in autoimmunity

Ralph Stadhouders et al.

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Dysfunctional signaling underlying endometriosis: current state of knowledge

Yeon Jean Cho et al.

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G protein-coupled estrogen receptor/miR-148a/human leukocyte antigen-G signaling pathway mediates cell apoptosis of ovarian endometriosis

Shun Zhi He et al.

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Regulatory T cells in autoimmune disease

Margarita Dominguez-Villar et al.

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SIRT1-Regulated Abnormal Acetylation of FOXP3 Induces Regulatory T-Cell Function Defect in Hashimoto's Thyroiditis

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Interleukin-23 as a therapeutic target for inflammatory myopathy

Natsuka Umezawa et al.

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Pro-Inflammatory Th1 and Th17 Cells Are Suppressed During Human Experimental Endotoxemia Whereas Anti-Inflammatory IL-10 Producing T-cells Are Unaffected

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NATURE REVIEWS DISEASE PRIMERS (2018)

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The link between immunity, autoimmunity and endometriosis: a literature update

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Epigenetic mechanisms regulating T-cell responses

Christian Schmidl et al.

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Diagnostic value of serum ICAM-1 for endometriosis A meta-analysis

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MEDICINE (2018)

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The Immunopathophysiology of Endometriosis

Lindsey K. Symons et al.

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MicroRNAs in Autoimmunity and Hematological Malignancies

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Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape

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Molecular and Cellular Pathogenesis of Endometriosis

Petra A. B. Klemmt et al.

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Epigenetic control of CD8+ T cell differentiation

Amanda N. Henning et al.

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Endometriosis and Female Pelvic Pain

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The Allostery Model of TCR Regulation

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Panel of Autoimmune Markers for Noninvasive Diagnosis of Minimal-Mild Endometriosis: A Multicenter Study

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Epidemiology of endometriosis and its comorbidities

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EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY (2017)

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Synergistic effect of regulatory T cells and proinflammatory cytokines in angiogenesis in the endometriotic milieu

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HUMAN REPRODUCTION (2017)

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Soluble VCAM-1/soluble ICAM-1 ratio is a promising biomarker for diagnosing endometriosis

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HUMAN REPRODUCTION (2017)

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Exacerbation of Endometriosis Due To Regulatory T-Cell Dysfunction

Yukiko Tanaka et al.

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What do we know about regulatory T cells and endometriosis? A systematic review

Isabela Bottura Leite de Barros et al.

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PreImplantation Factor in endometriosis: A potential role in inducing immune privilege for ectopic endometrium

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The role of vitamin C in epigenetic regulation

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Postepy Higieny I Medycyny Doswiadczalnej (2017)

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Ezh2 phosphorylation state determines its capacity to maintain CD8+ T memory precursors for antitumor immunity

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NATURE COMMUNICATIONS (2017)

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Unlocking the epigenetic code of T cell exhaustion

Jiazhu Wu et al.

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MR imaging of endometriosis: Spectrum of disease

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The Role of Epigenetics in Type 1 Diabetes

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The regulation of immune tolerance by FOXP3

Ling Lu et al.

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Epigenetic regulation of the pathological process in endometriosis

Kuei-Yang Hsiao et al.

REPRODUCTIVE MEDICINE AND BIOLOGY (2017)

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Epigenetics of CD4+ T cells in autoimmune diseases

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CURRENT OPINION IN RHEUMATOLOGY (2017)

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A Role for Histone Acetylation in the Developmental Regulation of V(D)J Recombination

Michelle Taylor McMurry et al.

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The transcriptional coactivator TAZ regulates reciprocal differentiation of TH17 cells and Treg cells

Jing Geng et al.

NATURE IMMUNOLOGY (2017)

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Endometriosis-associated infertility: aspects of pathophysiological mechanisms and treatment options

Tom Tanbo et al.

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2017)

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Progesterone resistance in endometriosis: origins, consequences and interventions

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ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA (2017)

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

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Estrogen anti-inflammatory activity on human monocytes is mediated through cross-talk between estrogen receptor ERα36 and GPR30/GPER1

Vasiliki Pelekanou et al.

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A current view of the role of epigenetic changes in the aetiopathogenesis of endometriosis

A. Kokcu

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Autoantigens as Partners in Initiation and Propagation of Autoimmune Rheumatic Diseases

Antony Rosen et al.

ANNUAL REVIEW OF IMMUNOLOGY, VOL 34 (2016)

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Aberrant Endometrial DNA Methylome and Associated Gene Expression in Women with Endometriosis

Sahar Houshdaran et al.

BIOLOGY OF REPRODUCTION (2016)

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The epigenetic role of vitamin C in health and disease

Vladimir Camarena et al.

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A Cholesterol-Based Allostery Model of T Cell Receptor Phosphorylation

Mahima Swamy et al.

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MicroRNA-17 Modulates Regulatory T Cell Function by Targeting Co-regulators of the Foxp3 Transcription Factor

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IMMUNITY (2016)

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Epigenetics: Novel Therapeutics Targeting Epigenetics

Stuart J. Conway et al.

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Reversal of fortune: estrogen receptor-β in endometriosis

Rosalia C. M. Simmen et al.

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Evaluation of estrogen in endometriosis patients: Regulation of GATA-3 in endometrial cells and effects on Th2 cytokines

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Can membrane progesterone receptor α on T regulatory cells explain the ensuing human labour?

Ana Areia et al.

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Increased percentage of Th17 cells in peritoneal fluid is associated with severity of endometriosis

Marek Gogacz et al.

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DNA methylation in endometriosis (Review)

Ourania Koukoura et al.

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1-Methyl-tryptophan attenuates regulatory T cells differentiation due to the inhibition of estrogen-IDO1-MRC2 axis in endometriosis

Chunyan Wei et al.

CELL DEATH & DISEASE (2016)

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New insights into Regulatory T Cells: exosome- and Non-Coding RNA-Mediated Regulation of Homeostasis and Resident Treg Cells

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Dyslipidemia in patients with systemic lupus erythematosus: Association with disease activity and B-type natriuretic peptide levels

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Endometriosis allergic or autoimmune disease: pathogenetic aspects - a case control study

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Simultaneous Detection and Evaluation of Four Subsets of CD4+T Lymphocyte in Lesions and Peripheral Blood in Endometriosis

Masashi Takamura et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2015)

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Estrogen Receptor β Modulates Apoptosis Complexes and the Inflammasome to Drive the Pathogenesis of Endometriosis

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CELL (2015)

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FOXP3+ regulatory T cells and their functional regulation

Zhiyuan Li et al.

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Estrogen receptors regulate innate immune cells and signaling pathways

Susan Kovats

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Endometriosis-induced changes in regulatory T cells - insights towards developing permanent contraception

Asgerally T. Fazleabas et al.

CONTRACEPTION (2015)

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An epigenetic toolkit allows for diverse genome architectures in eukaryotes

Xyrus X. Maurer-Alcala et al.

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PD-1/PD-L1 inhibitors

Joel Sunshine et al.

CURRENT OPINION IN PHARMACOLOGY (2015)

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Progesterone promotes maternal-fetal tolerance by reducing human maternal T-cell polyfunctionality and inducing a specific cytokine profile

David Lissauer et al.

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The Chromatin-Modifying Enzyme Ezh2 Is Critical for the Maintenance of Regulatory T Cell Identity after Activation

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IMMUNITY (2015)

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Epigenetic dynamics during CD4+ T cells lineage commitment

Ramon M. Rodriguez et al.

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Mammalian Sterile 20-like Kinase 1 (Mst1) Enhances the Stability of Forkhead Box P3 (Foxp3) and the Function of Regulatory T Cells by Modulating Foxp3 Acetylation

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Alternative Activation of Human Macrophages Is Rescued by Estrogen Treatment In Vitro and Impaired by Menopausal Status

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MicroRNA-15b/16 Enhances the Induction of Regulatory T Cells by Regulating the Expression of Rictor and mTOR

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IL-17A Contributes to the Pathogenesis of Endometriosis by Triggering Proinflammatory Cytokines and Angiogenic Growth Factors

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Development of a unique epigenetic signature during in vivo Th17 differentiation

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H3K27me3 is an Epigenetic Mark of Relevance in Endometriosis

Mariano Colon-Caraballo et al.

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Epigenetic and transcriptional control of Foxp3+ regulatory T cells

Jochen Huehn et al.

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Pathophysiology and Immune Dysfunction in Endometriosis

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Epigenetic control of thymic Treg-cell development

Yohko Kitagawa et al.

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Perforin: structure, function, and role in human immunopathology

Ilia Voskoboinik et al.

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FOXP3 is a direct target of miR15al16 in umbilical cord blood regulatory T cells

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Transgenerational Epigenetic Inheritance: Myths and Mechanisms

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Epigenetic Regulation of Pluripotency and Differentiation

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Aberrant histone modification in endometriosis

Kaei Nasu et al.

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Genetic and epigenetic basis of Treg cell development and function: from a FoxP3-centered view to an epigenome-defined view of natural Treg cells

Hiromasa Morikawa et al.

IMMUNOLOGICAL REVIEWS (2014)

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Article Immunology

microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells

Antoine Marcais et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2014)

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Multiple autoimmunity, type 1 diabetes (T1DM), autoimmune thyroiditis and thyroid cancer: is there an association? A case report and literature review

Kyriaki Karavanaki et al.

JOURNAL OF PEDIATRIC ENDOCRINOLOGY & METABOLISM (2014)

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Article Endocrinology & Metabolism

Genome-Wide Analysis of Histone Modifications in Human Endometrial Stromal Cells

Isao Tamura et al.

MOLECULAR ENDOCRINOLOGY (2014)

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Pathogenic conversion of Foxp3(+) T cells into T(H)17 cells in autoimmune arthritis

Noriko Komatsu et al.

NATURE MEDICINE (2014)

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Genome-Wide DNA Methylation Profiling in Cultured Eutopic and Ectopic Endometrial Stromal Cells

Yoshiaki Yamagata et al.

PLOS ONE (2014)

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Endometriosis Is Characterized by a Distinct Pattern of Histone 3 and Histone 4 Lysine Modifications

Janice B. Monteiro et al.

REPRODUCTIVE SCIENCES (2014)

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Article Genetics & Heredity

Genome-Wide DNA Methylation Analysis Predicts an Epigenetic Switch for GATA Factor Expression in Endometriosis

Matthew T. Dyson et al.

PLOS GENETICS (2014)

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Review Immunology

Positive and negative selection of the T cell repertoire: what thymocytes see (and don't see)

Ludger Klein et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Article Obstetrics & Gynecology

Aberrant histone acetylation and methylation levels in woman with endometriosis

Xia Xiaomeng et al.

ARCHIVES OF GYNECOLOGY AND OBSTETRICS (2013)

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Cytotoxic T-Cells in Peripheral Blood in Women with Endometriosis

N. Slabe et al.

GEBURTSHILFE UND FRAUENHEILKUNDE (2013)

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Article Obstetrics & Gynecology

CD4+ CD25+ FOXP3+ regulatory T cells in peripheral blood and peritoneal fluid of patients with endometriosis

Joanna Olkowska-Truchanowicz et al.

HUMAN REPRODUCTION (2013)

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Article Immunology

Self-antigen-Driven Activation Induces Instability of Regulatory T Cells during an Inflammatory Autoimmune Response

Samantha L. Bailey-Bucktrout et al.

IMMUNITY (2013)

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Development and Maintenance of Regulatory T cells

Naganari Ohkura et al.

IMMUNITY (2013)

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Article Biochemistry & Molecular Biology

T Cell Receptor (TCR) and Transforming Growth Factor β (TGF-β) Signaling Converge on DNA (Cytosine-5)-methyltransferase to Control forkhead box protein 3 (foxp3) Locus Methylation and Inducible Regulatory T Cell Differentiation

Chaoran Li et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2013)

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Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells

Yoko Urata et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2013)

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Genetic polymorphism in FOXP3 gene: imbalance in regulatory T-cell role and development of human diseases

Julie Massayo Maeda Oda et al.

JOURNAL OF GENETICS (2013)

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Recent Thymic Emigrants and Mature Naive T Cells Exhibit Differential DNA Methylation at Key Cytokine Loci

Amy M. Berkley et al.

JOURNAL OF IMMUNOLOGY (2013)

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Article Dermatology

mTORC2-PKBα/Akt1 Serine 473 Phosphorylation Axis Is Essential for Regulation of FOXP3 Stability by Chemokine CCL3 in Psoriasis

Ling Chen et al.

JOURNAL OF INVESTIGATIVE DERMATOLOGY (2013)

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Antisense Transcript Long Noncoding RNA (lncRNA) HOTAIR is Transcriptionally Induced by Estradiol

Arunoday Bhan et al.

JOURNAL OF MOLECULAR BIOLOGY (2013)

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Estrogen modulates in vitro T cell responses in a concentration- and receptor-dependent manner: Effects on intracellular molecular targets and antioxidant enzymes

Hannah P. Priyanka et al.

MOLECULAR IMMUNOLOGY (2013)

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Molecular determinants of regulatory T cell development: the essential roles of epigenetic changes

Yohko Kitagawa et al.

FRONTIERS IN IMMUNOLOGY (2013)

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Expression of Th1 and Th2 cytokine-associated transcription factors, T-bet and GATA-3, in the eutopic endometrium of women with endometriosis

Peng Chen et al.

ACTA HISTOCHEMICA (2012)

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Article Immunology

CD4+CD25highFoxp3+Cells Increased in the Peritoneal Fluid of Patients with Endometriosis

Sergio Podgaec et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2012)

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Article Biochemistry & Molecular Biology

Lipid and lipid mediator profiling of human synovial fluid in rheumatoid arthritis patients by means of LC-MS/MS

Martin Giera et al.

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2012)

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Foxp3 Exploits a Pre-Existent Enhancer Landscape for Regulatory T Cell Lineage Specification

Robert M. Samstein et al.

CELL (2012)

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Epigenetics Judge, jury and executioner of stem cell fate

James R. Tollervey et al.

EPIGENETICS (2012)

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Pathogenesis and pathophysiology of endometriosis

Richard O. Burney et al.

FERTILITY AND STERILITY (2012)

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T Cell Receptor Stimulation-Induced Epigenetic Changes and Foxp3 Expression Are Independent and Complementary Events Required for Treg Cell Development

Naganari Ohkura et al.

IMMUNITY (2012)

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The treatment strategies of autoimmune disease may need a different approach from conventional protocol: A review

S. Chandrashekara

INDIAN JOURNAL OF PHARMACOLOGY (2012)

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MicroRNA Profile of Circulating CD4-positive Regulatory T Cells in Human Adults and Impact of Differentially Expressed MicroRNAs on Expression of Two Genes Essential to Their Function

Hussein Fayyad-Kazan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2012)

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Transcription factor Foxp3 and its protein partners form a complex regulatory network

Dipayan Rudra et al.

NATURE IMMUNOLOGY (2012)

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Epigenetic protein families: a new frontier for drug discovery

Cheryl H. Arrowsmith et al.

NATURE REVIEWS DRUG DISCOVERY (2012)

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Expression of HOXA11 in the mid-luteal endometrium from women with endometriosis-associated infertility

Malgorzata Szczepanska et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2012)

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Expression of the T regulatory cell transcription factor FoxP3 in peri-implantation phase endometrium in infertile women with endometriosis

Shufang Chen et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2012)

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G Protein-Coupled Estrogen Receptor (GPER) Expression in Normal and Abnormal Endometrium

Beth J. Plante et al.

REPRODUCTIVE SCIENCES (2012)

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T-Cell Tolerance: Central and Peripheral

Yan Xing et al.

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY (2012)

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T Cell Adaptive Immunity Proceeds through Environment-Induced Adaptation from the Exposure of Cryptic Genetic Variation

James M. Whitacre et al.

Frontiers in Genetics (2012)

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DNA hypomethylation of the COX-2 gene promoter is associated with up-regulation of its mRNA expression in eutopic endometrium of endometriosis

DanBo Wang et al.

EUROPEAN JOURNAL OF MEDICAL RESEARCH (2012)

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Why must T cells be cross-reactive?

Andrew K. Sewell

NATURE REVIEWS IMMUNOLOGY (2012)

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Regulation and function of mTOR signalling in T cell fate decisions

Hongbo Chi

NATURE REVIEWS IMMUNOLOGY (2012)

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The molecular basis of the memory T cell response: differential gene expression and its epigenetic regulation

Nan-ping Weng et al.

NATURE REVIEWS IMMUNOLOGY (2012)

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Lymphocytes in Endometriosis

Yutaka Osuga et al.

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY (2011)

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Clinical Improvement in Psoriasis With Treatment of Associated Hyperlipidemia

Ramin Ghazizadeh et al.

AMERICAN JOURNAL OF THE MEDICAL SCIENCES (2011)

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MicroRNA-126 Regulates DNA Methylation in CD4+T Cells and Contributes to Systemic Lupus Erythematosus by Targeting DNA Methyltransferase 1

Sha Zhao et al.

ARTHRITIS AND RHEUMATISM (2011)

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Immune interactions in endometriosis

Jennifer L. Herington et al.

EXPERT REVIEW OF CLINICAL IMMUNOLOGY (2011)

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Deoxyribonucleic acid methyltransferases and methyl-CpG-binding domain proteins in human endometrium and endometriosis

Kim J. A. F. van Kaam et al.

FERTILITY AND STERILITY (2011)

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Editorial Material Obstetrics & Gynecology

T helper (Th)1, Th2, and Th17 interleukin pathways in infertile patients with minimal/mild endometriosis

Carolina Giordani Andreoli et al.

FERTILITY AND STERILITY (2011)

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miR-146a is a significant brake on autoimmunity, myeloproliferation, and cancer in mice

Mark P. Boldin et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2011)

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Estrogen Receptor α Signaling in T Lymphocytes Is Required for Estradiol-Mediated Inhibition of Th1 and Th17 Cell Differentiation and Protection against Experimental Autoimmune Encephalomyelitis

Karine Lelu et al.

JOURNAL OF IMMUNOLOGY (2011)

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High TCR Stimuli Prevent Induced Regulatory T Cell Differentiation in a NF-κB-Dependent Manner

Luciana L. Molinero et al.

JOURNAL OF IMMUNOLOGY (2011)

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Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

Marc Beyer et al.

NATURE IMMUNOLOGY (2011)

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Rapid Temporal Control of Foxp3 Protein Degradation by Sirtuin-1

Jorg van Loosdregt et al.

PLOS ONE (2011)

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Hypermethylation of the CpG Island Spanning From Exon II to Intron III is Associated With Steroidogenic Factor 1 Expression in Stromal Cells of Endometriosis

Qing Xue et al.

REPRODUCTIVE SCIENCES (2011)

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Registries in rheumatoid arthritis and autoimmune diseases: data from the French registries

Xavier Mariette et al.

RHEUMATOLOGY (2011)

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Recombination centres and the orchestration of V(D)J recombination

David G. Schatz et al.

NATURE REVIEWS IMMUNOLOGY (2011)

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The In Vivo Pattern of Binding of RAG1 and RAG2 to Antigen Receptor Loci

Yanhong Ji et al.

CELL (2010)

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Function of miR-146a in Controlling Treg Cell-Mediated Regulation of Th1 Responses

Li-Fan Lu et al.

CELL (2010)

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Experimental endometriosis in immunocompromised mice after adoptive transfer of human leukocytes

Kaylon L. Bruner-Tran et al.

FERTILITY AND STERILITY (2010)

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Epigenetics and gene expression

E. R. Gibney et al.

HEREDITY (2010)

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Genome-Wide Identification of Human FOXP3 Target Genes in Natural Regulatory T Cells

Timothy J. Sadlon et al.

JOURNAL OF IMMUNOLOGY (2010)

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The RING Domain of RAG1 Ubiquitylates Histone H3: A Novel Activity in Chromatin-Mediated Regulation of V(D)J Joining

Ursula Grazini et al.

MOLECULAR CELL (2010)

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Role of conserved non-coding DNA elements in the Foxp3 gene in regulatory T-cell fate

Ye Zheng et al.

NATURE (2010)

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The frequency of CD25+CD4+and FOXP3+regulatory T cells in ectopic endometrium and ectopic decidua

Pawel Basta et al.

REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY (2010)

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Epigenetic control of Tcrb gene rearrangement

Salvatore Spicuglia et al.

SEMINARS IN IMMUNOLOGY (2010)

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Estrogen Receptor-beta, Estrogen Receptor-alpha, and Progesterone Resistance in Endometriosis

Serdar E. Bulun et al.

SEMINARS IN REPRODUCTIVE MEDICINE (2010)

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Chromatin Architecture and the Generation of Antigen Receptor Diversity

Suchit Jhunjhunwala et al.

CELL (2009)

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T regulatory cells and their counterparts: masters of immune regulation

C. Ozdemir et al.

CLINICAL AND EXPERIMENTAL ALLERGY (2009)

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Human natural Treg microRNA signature: Role of microRNA-31 and microRNA-21 in FOXP3 expression

Redouane Rouas et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

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An operational definition of epigenetics

Shelley L. Berger et al.

GENES & DEVELOPMENT (2009)

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Foxp3-Dependent MicroRNA155 Confers Competitive Fitness to Regulatory T Cells by Targeting SOCS1 Protein

Li-Fan Lu et al.

IMMUNITY (2009)

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Nuclear Factor-κB Modulates Regulatory T Cell Development by Directly Regulating Expression of Foxp3 Transcription Factor

Meixiao Long et al.

IMMUNITY (2009)

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Cutting Edge: The Foxp3 Target miR-155 Contributes to the Development of Regulatory T Cells

Susan Kohlhaas et al.

JOURNAL OF IMMUNOLOGY (2009)

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IDO Activates Regulatory T Cells and Blocks Their Conversion into Th17-Like T Cells

Babak Baban et al.

JOURNAL OF IMMUNOLOGY (2009)

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miR-22 Inhibits Estrogen Signaling by Directly Targeting the Estrogen Receptor α mRNA

Deo Prakash Pandey et al.

MOLECULAR AND CELLULAR BIOLOGY (2009)

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H3K4me3 Stimulates the V(D)J RAG Complex for Both Nicking and Hairpinning in trans in Addition to Tethering in cis: Implications for Translocations

Noriko Shimazaki et al.

MOLECULAR CELL (2009)

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Mechanisms of Disease: Interleukin-17 and Type 17 Helper T Cells.

Pierre Miossec et al.

NEW ENGLAND JOURNAL OF MEDICINE (2009)

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Nonhuman Primate Models for Translational Research in Endometriosis

T. M. D'Hooghe et al.

REPRODUCTIVE SCIENCES (2009)

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How do Regulatory T Cells Work?

A. Corthay

SCANDINAVIAN JOURNAL OF IMMUNOLOGY (2009)

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Lipid Profiles in Patients with Rheumatoid Arthritis: Mechanisms and the Impact of Treatment

George Steiner et al.

SEMINARS IN ARTHRITIS AND RHEUMATISM (2009)

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Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?

Jochen Huehn et al.

NATURE REVIEWS IMMUNOLOGY (2009)

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Interleukin-4 stimulates proliferation of endometriotic stromal cells

Zhuo OuYang et al.

AMERICAN JOURNAL OF PATHOLOGY (2008)

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Interleukin (IL)-17A stimulates IL-8 secretion, cyclooxygensase-2 expression, and cell proliferation of endometriotic stromal cells

Tetsuya Hirata et al.

ENDOCRINOLOGY (2008)

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An epigenetic disorder may cause aberrant expression of aromatase gene in endometriotic stromal cells

Masao Izawa et al.

FERTILITY AND STERILITY (2008)

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Selective modification of antigen-specific T cells by RNA electroporation

Duane A. Mitchell et al.

HUMAN GENE THERAPY (2008)

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Role of Th1 and Th17 cells in organ-specific autoimmunity

Valerie Dardalhon et al.

JOURNAL OF AUTOIMMUNITY (2008)

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Dicer-dependent microRNA pathway safeguards regulatory T cell function

Adrian Liston et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

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Selective miRNA disruption in T reg cells leads to uncontrolled autoimmunity

Xuyu Zhou et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2008)

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Productive coupling of accessible Vβ14 segments and DJβ complexes determines the frequency of Vβ14 rearrangement

Sheila Ranganath et al.

JOURNAL OF IMMUNOLOGY (2008)

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RAG2 PHD finger couples histone H3 lysine 4 trimethylation with V(D)J recombination

Adam G. W. Matthews et al.

NATURE (2007)

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The plant homeodomain finger of RAG2 recognizes histone H3 methylated at both lysine-4 and arginine-2

Santiago Ramon-Maiques et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)

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Article Biochemistry & Molecular Biology

Noncoding transcription controls downstream promoters to regulate T-cell receptor α recombination

Iratxe Abarrategui et al.

EMBO JOURNAL (2007)

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Promoter methylation regulates estrogen receptor 2 in human endometrium and endometriosis

Qing Xue et al.

BIOLOGY OF REPRODUCTION (2007)

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A plant homeodomain in Rag-2 that binds hypermethylated lysine 4 of histone H3 is necessary for efficient antigen-receptor-gene rearrangement

Yun Liu et al.

IMMUNITY (2007)

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Transcriptional activation of steroidogenic factor-1 by hypomethylation of the 5′ CpG island in endometriosis

Qing Xue et al.

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2007)

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Review Immunology

T cell development: better living through chromatin

Michael S. Krangel

NATURE IMMUNOLOGY (2007)

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Review Immunology

Apoptosis induced by the lymphocyte effector molecule perforin

Paul Bolitho et al.

CURRENT OPINION IN IMMUNOLOGY (2007)

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Article Obstetrics & Gynecology

Endometriosis: an inflammatory disease with a Th2 immune response component

S. Podgaec et al.

HUMAN REPRODUCTION (2007)

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Vitamin C promotes human endothelial cell growth via the ERK-signaling pathway

Gudrun Ulrich-Merzenich et al.

EUROPEAN JOURNAL OF NUTRITION (2007)

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Article Obstetrics & Gynecology

Aberrant expression of deoxyribonucleic acid methyltransferases DNMT1, DNMT3A, and DNMT3B in women with endometriosis

Yan Wu et al.

FERTILITY AND STERILITY (2007)

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Review Rheumatology

Primer: epigenetics of autoimmunity

Bruce Richardson

NATURE CLINICAL PRACTICE RHEUMATOLOGY (2007)

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CD127 expression inversely correlates with FoxP3 and suppressive function of human CD4+ T reg cells

Weihong Liu et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2006)

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Article Biochemistry & Molecular Biology

Promoter Hypermethylation of Progesterone Receptor Isoform B (PR-B) in Endometriosis

Yan Wu et al.

EPIGENETICS (2006)

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Article Obstetrics & Gynecology

Peritoneal fluid concentrations of interleukin-17 correlate with the severity of endometriosis and infertility of this disorder

XM Zhang et al.

BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY (2005)

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Article Immunology

IL-23 up-regulates IL-10 and induces IL-17 synthesis by polyclonally activated naive T cells in human

S Vanden Eijnden et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2005)

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Letter Biochemistry & Molecular Biology

Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets

BP Lewis et al.

CELL (2005)

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Decreased T cell ERK pathway signaling may contribute to the development of lupus through effects on DNA methylation and gene expression

K Oelke et al.

INTERNATIONAL REVIEWS OF IMMUNOLOGY (2004)

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Impaired V(D)J recombination and lymphocyte development in core RAG1-expressing mice

DD Dudley et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2003)

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DNA methylation and chromatin structure regulate T cell perforin gene expression

QJ Lu et al.

JOURNAL OF IMMUNOLOGY (2003)

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Pathogenesis of endometriosis: natural immunity dysfunction or autoimmune disease?

G Matarese et al.

TRENDS IN MOLECULAR MEDICINE (2003)

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Foxp3 programs the development and function of CD4+CD25+ regulatory T cells

JD Fontenot et al.

NATURE IMMUNOLOGY (2003)

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A role for histone acetylation in the developmental regulation of V(D)J recombination

MT McMurry et al.

SCIENCE (2000)

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