☆ 4.8 Review

Intestinal Microbiota - An Unmissable Bridge to Severe Acute Pancreatitis-Associated Acute Lung Injury

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Signal Pathways and Markers Involved in Acute Lung Injury Induced by Acute Pancreatitis

Jialin Zhou et al.

Summary: This paper summarizes the pathophysiological mechanisms of acute pancreatitis leading to acute lung injury, as well as relevant signal transduction pathways and biomarkers, providing researchers with a better understanding of the underlying mechanisms controlling AP and ALI.

DISEASE MARKERS (2021)

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Article Immunology

Suppression of NLRP3 inflammasome by Platycodin D via the TLR4/MyD88/NF-κB pathway contributes to attenuation of lipopolysaccharide induced acute lung injury in rats

Yongcan Wu et al.

Summary: Pre-treatment with PLD alleviates lung inflammation and injury induced by LPS, reduces inflammatory cytokine levels, modulates oxidative stress-related factors in lung tissue, and inhibits the activation of NLRP3 and NF-kappa B signaling pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2021)

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Review Biochemistry & Molecular Biology

Probiotics, Prebiotics and Epithelial Tight Junctions: A Promising Approach to Modulate Intestinal Barrier Function

Elizabeth C. Rose et al.

Summary: This review summarizes the effects of probiotics and prebiotics on the intestinal epithelial barrier and non-epithelial barrier constituents, such as the enteric glial cell network, and investigates their potential therapeutic benefits in preventing and treating gastrointestinal diseases associated with impaired intestinal barrier function and dysbiosis.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

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Review Nutrition & Dietetics

Gut Microbiota and Probiotics/Synbiotics for Modulation of Immunity in Critically Ill Patients

Kentaro Shimizu et al.

Summary: Patients with critical illness often experience inflammatory responses that can worsen disease progression. Modulating immune response and preventing infections are crucial in managing systemic inflammation. Maintaining gut microbiota with probiotics and synbiotics can help reduce inflammation and prevent infections among critically ill patients. Further research is needed to advance intestinal therapies for critical care patients.

NUTRIENTS (2021)

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Article Multidisciplinary Sciences

Mucosa-associated gut microbiota reflects clinical course of ulcerative colitis

Yuichiro Nishihara et al.

Summary: This study shows that reduced diversity and specific microbes in the gut microbiota are associated with the later clinical course of relapse events and treatment response in UC patients. Patients with lower diversity and a higher proportion of Bacteroides at enrollment were more likely to experience relapse, while those with lower diversity and a lower proportion of Prevotella were less likely to respond well to treatment.

SCIENTIFIC REPORTS (2021)

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Article Multidisciplinary Sciences

Untargeted metabolomics and transcriptomics identified glutathione metabolism disturbance and PCS and TMAO as potential biomarkers for ER stress in lung

Zijing Wang et al.

Summary: ER stress is a cellular state resulting from the accumulation of unfolded/misfolded proteins in the ER, and can lead to cell death if not properly resolved. This study integrated metabolomic and transcriptomic data from total lung to investigate the pathogenic state of ER stress, revealing alterations in critical pathways related to energy expenditure, signal transduction, and redox homeostasis. The identification of potential ER stress biomarkers and the role of glutathione metabolism in maintaining redox homeostasis in cells are highlighted in this research.

SCIENTIFIC REPORTS (2021)

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Review Immunology

Targeting TLR4 Signaling to Blunt Viral-Mediated Acute Lung Injury

Kari Ann Shirey et al.

Summary: Respiratory viral infections, such as influenza, can lead to severe consequences due to misalignments between circulating strains and predicted vaccine strains. In addition to traditional antiviral treatments, blocking the host's immune response may offer a more effective approach to combat these infections.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Microbiology

Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis through reducing neutrophil infiltration

Yuanyuan Lei et al.

Summary: Heparanase exacerbates acute pancreatitis through its interaction with the gut microbiota, particularly the commensal Parabacteroides. In addition, Parabacteroides produces acetate to alleviate heparanase-exacerbated acute pancreatitis by reducing neutrophil infiltration, suggesting a potential therapeutic strategy for acute pancreatitis.

MICROBIOME (2021)

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Article Multidisciplinary Sciences

FOXC2 controls adult lymphatic endothelial specialization, function, and gut lymphatic barrier preventing multiorgan failure

Alejandra Gonzalez-Loyola et al.

Summary: Inactivation of Foxc2 in adult lymphatic endothelium leads to a stepwise intestine-to-lung systemic failure, compromising gut epithelial barrier and promoting dysbiosis. The loss of Foxc2 skewed the specialization of lymphatic endothelial subsets, resulting in populations with mixed identities and emergence of lymph node-like endothelial cells.

SCIENCE ADVANCES (2021)

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Article Cardiac & Cardiovascular Systems

Probiotic Saccharomyces boulardii Alleviates Lung Injury by Reduction of Oxidative Stress and Cytokine Response Induced by Supraceliac Aortic Ischemia-Reperfusion Injury in Rats

Selim Durmaz et al.

Summary: Oral supplementation of probiotic Saccharomyces boulardii before supraceliac aortic ischemia-reperfusion in rats alleviates lung injury by reducing oxidative stress, intestinal cellular damage, and modulation of inflammatory processes.

BRAZILIAN JOURNAL OF CARDIOVASCULAR SURGERY (2021)

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Article Critical Care Medicine

Exosomal miR-30d-5p of neutrophils induces M1 macrophage polarization and primes macrophage pyroptosis in sepsis-related acute lung injury

Yang Jiao et al.

Summary: The study demonstrated that exosomal miR-30d-5p from PMNs contributed to sepsis-related ALI by inducing M1 macrophage polarization and priming macrophage pyroptosis through activating NF-kappa B signaling. These findings suggest a novel mechanism of PMN-M phi interaction in sepsis-related ALI, which may provide new therapeutic strategies in sepsis patients.

CRITICAL CARE (2021)

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Review Gastroenterology & Hepatology

Guidelines for reporting on animal fecal transplantation (GRAFT) studies: recommendations from a systematic review of murine transplantation protocols

Kate R. Secombe et al.

Summary: The systematic review identified inconsistencies and incompleteness in reporting of preclinical FMT protocols in mouse models. To address these limitations, Guidelines for Reporting Animal Fecal Transplant (GRAFT) were developed to improve the quality of reporting and peer review in preclinical FMT studies.

GUT MICROBES (2021)

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Article Medicine, General & Internal

Altered intestinal microflora and barrier injury in severe acute pancreatitis can be changed by zinc

Shi-yue Su et al.

Summary: The study showed that zinc supplementation in rats with severe acute pancreatitis resulted in lower levels of serum amylase and plasma endotoxin, reduced intestinal mucosal permeability and endotoxemia, decreased bacterial translocation, and inhibited changes in pathogenic intestinal flora.

INTERNATIONAL JOURNAL OF MEDICAL SCIENCES (2021)

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Review Gastroenterology & Hepatology

American Gastroenterological Association Clinical Practice Update: Management of Pancreatic Necrosis

Todd H. Baron et al.

GASTROENTEROLOGY (2020)

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Article Gastroenterology & Hepatology

Scientific frontiers in faecal microbiota transplantation: joint document of Asia-Pacific Association of Gastroenterology (APAGE) and Asia-Pacific Society for Digestive Endoscopy (APSDE)

Siew C. Ng et al.

GUT (2020)

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Article Medicine, Research & Experimental

HMGB1 participates in LPS-induced acute lung injury by activating the AIM2 inflammasome in macrophages and inducing polarization of M1 macrophages via TLR2, TLR4, and RAGE/NF-κB signaling pathways

Jing Wang et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2020)

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Article Critical Care Medicine

Lung Microbiota Predict Clinical Outcomes in Critically Ill Patients

Robert P. Dickson et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2020)

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Article Biochemical Research Methods

Metabolomic profile perturbations of serum, lung, bronchoalveolar lavage fluid, spleen and feces in LPS-induced acute lung injury rats based on HPLC-ESI-QTOF-MS

Tianyang Wang et al.

ANALYTICAL AND BIOANALYTICAL CHEMISTRY (2020)

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Article Gastroenterology & Hepatology

Identification of Dysfunctional Gut Microbiota Through Rectal Swab in Patients with Different Severity of Acute Pancreatitis

Shanshan Yu et al.

DIGESTIVE DISEASES AND SCIENCES (2020)

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Article Gastroenterology & Hepatology

Efficacy of faecal microbiota transplantation for patients with irritable bowel syndrome in a randomised, double-blind, placebo-controlled study

Magdy El-Salhy et al.

GUT (2020)

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Review Critical Care Medicine

Selective decontamination of the digestive tract (SDD) in critically ill patients: a narrative review

Bastiaan H. J. Wittekamp et al.

INTENSIVE CARE MEDICINE (2020)

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Review Biotechnology & Applied Microbiology

Surface components and metabolites of probiotics for regulation of intestinal epithelial barrier

Qing Liu et al.

MICROBIAL CELL FACTORIES (2020)

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Article Gastroenterology & Hepatology

Lactobacillus reuteri maintains intestinal epithelial regeneration and repairs damaged intestinal mucosa

Haiqin Wu et al.

GUT MICROBES (2020)

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Article Biochemistry & Molecular Biology

Mucins and the Microbiome

Gunnar C. Hansson

Annual Review of Biochemistry (2020)

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Article Cell Biology

Gut Dysbiosis during Influenza Contributes to Pulmonary Pneumococcal Superinfection through Altered Short-Chain Fatty Acid Production

Valentin Sencio et al.

CELL REPORTS (2020)

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Review Immunology

The Gut-Lung Axis in Health and Respiratory Diseases: A Place for Inter-Organ and Inter-Kingdom Crosstalks

Raphael Enaud et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2020)

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Article Infectious Diseases

Effect of probiotics on gut microbiome in patients with administration of surgical antibiotic prophylaxis: A randomized controlled study

Norihito Kaku et al.

JOURNAL OF INFECTION AND CHEMOTHERAPY (2020)

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Review Gastroenterology & Hepatology

Role of gut microbiota on intestinal barrier function in acute pancreatitis

Xue-Yang Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2020)

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Article Biochemical Research Methods

Proteomic analysis reveals the protective effects of emodin on severe acute pancreatitis induced lung injury by inhibiting neutrophil proteases activity

Caiming Xu et al.

JOURNAL OF PROTEOMICS (2020)

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Article Cell Biology

Picroside II Improves Severe Acute Pancreatitis-Induced Intestinal Barrier Injury by Inactivating Oxidative and Inflammatory TLR4-Dependent PI3K/AKT/NF-κB Signaling and Improving Gut Microbiota

Xuehua Piao et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Review Pharmacology & Pharmacy

Acute lung injury: The therapeutic role of Rho kinase inhibitors

Farshad Abedi et al.

PHARMACOLOGICAL RESEARCH (2020)

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Article Cell Biology

HMGB1 aggravates lipopolysaccharide-induced acute lung injury through suppressing the activity and function of Tregs

Ruiting Li et al.

CELLULAR IMMUNOLOGY (2020)

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Review Cell Biology

Macrophage polarization and its role in the pathogenesis of acute lung injury/acute respiratory distress syndrome

Xuxin Chen et al.

INFLAMMATION RESEARCH (2020)

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Article Immunology

HMGB1/PI3K/Akt/mTOR Signaling Participates in the Pathological Process of Acute Lung Injury by Regulating the Maturation and Function of Dendritic Cells

Ruiting Li et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Immunology

Pulmonary Innate Immune Response Determines the Outcome of Inflammation During Pneumonia and Sepsis-Associated Acute Lung Injury

Vijay Kumar

FRONTIERS IN IMMUNOLOGY (2020)

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Article Biotechnology & Applied Microbiology

Mesenteric Lymph Duct Drainage Attenuates Lung Inflammatory Injury and Inhibits Endothelial Cell Apoptosis in Septic Rats

Yongjun Liu et al.

BIOMED RESEARCH INTERNATIONAL (2020)

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Review Immunology

Probiotics in Medicine: A Long Debate

Elisavet Stavropoulou et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Review Microbiology

Gut Microbiota and Immune System Interactions

Ji Youn Yoo et al.

MICROORGANISMS (2020)

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Review Medicine, Research & Experimental

Intestinal barrier damage, systemic inflammatory response syndrome, and acute lung injury: A troublesome trio for acute pancreatitis

Peng Ge et al.

BIOMEDICINE & PHARMACOTHERAPY (2020)

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Article Cell Biology

Saikosaponin A-Induced Gut Microbiota Changes Attenuate Severe Acute Pancreatitis through the Activation of Keap1/Nrf2-ARE Antioxidant Signaling

Jing Li et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2020)

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Article Multidisciplinary Sciences

Effect of antibiotic gut microbiota disruption on LPS-induced acute lung inflammation

Max C. Jacobs et al.

PLOS ONE (2020)

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Review Agriculture, Dairy & Animal Science

Regulation of the intestinal barrier by nutrients: The role of tight junctions

Takuya Suzuki

ANIMAL SCIENCE JOURNAL (2020)

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Article Critical Care Medicine

Serial change of neutrophil extracellular traps in tracheal aspirate of patients with acute respiratory distress syndrome: report of three cases

Masahiro Ojima et al.

JOURNAL OF INTENSIVE CARE (2020)

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Article Medicine, Research & Experimental

Analyses of alveolar epithelial injury via lipid-related stress in mammalian target of rapamycin inhibitor-induced lung disease

Nariaki Kokuho et al.

LABORATORY INVESTIGATION (2019)

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Review Nutrition & Dietetics

Factors That Worsen Disease Severity in Acute Pancreatitis: Implications for More Innovative Nutrition Therapy

Stephen A. McClave

NUTRITION IN CLINICAL PRACTICE (2019)

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Review Emergency Medicine

2019 WSES guidelines for the management of severe acute pancreatitis

Ari Leppaniemi et al.

WORLD JOURNAL OF EMERGENCY SURGERY (2019)

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Review Immunology

Challenge to the Intestinal Mucosa During Sepsis

Felix Haussner et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Review Immunology

Microbiota-Immune Interaction in the Pathogenesis of Gut-Derived Infection

Chenyang Wang et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Cell Biology

Paneth Cell Ablation Aggravates Pancreatic and Intestinal Injuries in a Rat Model of Acute Necrotizing Pancreatitis after Normal and High-Fat Diet

Yuecheng Guo et al.

MEDIATORS OF INFLAMMATION (2019)

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Article Cell Biology

Lipoxin A4 Ameliorates Acute Pancreatitis-Associated Acute Lung Injury through the Antioxidative and Anti-Inflammatory Effects of the Nrf2 Pathway

Wen Ye et al.

OXIDATIVE MEDICINE AND CELLULAR LONGEVITY (2019)

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Review Medicine, Research & Experimental

Clinical Application and Potential of Fecal Microbiota Transplantation

R. E. Ooijevaar et al.

ANNUAL REVIEW OF MEDICINE, VOL 70 (2019)

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Review Pharmacology & Pharmacy

Gut Microbiota-Dependent Marker TMAO in Promoting Cardiovascular Disease: Inflammation Mechanism, Clinical Prognostic, and Potential as a Therapeutic Target

Shengjie Yang et al.

FRONTIERS IN PHARMACOLOGY (2019)

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Article Immunology

Obeticholic acid alleviate lipopolysaccharide-induced acute lung injury via its anti-inflammatory effects in mice

Jun Fei et al.

INTERNATIONAL IMMUNOPHARMACOLOGY (2019)

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Review Biochemistry & Molecular Biology

The Role of the Microbiome in Asthma: The Gut-Lung Axis

Franco Frati et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2019)

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Article Gastroenterology & Hepatology

Gut microbiota dysbiosis worsens the severity of acute pancreatitis in patients and mice

Yin Zhu et al.

JOURNAL OF GASTROENTEROLOGY (2019)

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Review Biochemistry & Molecular Biology

Immunomodulatory potential of gut microbiome-derived short-chain fatty acids (SCFAs)

Weronika Ratajczak et al.

ACTA BIOCHIMICA POLONICA (2019)

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Review Immunology

Short Chain Fatty Acids (SCFAs)-Mediated Gut Epithelial and Immune Regulation and Its Relevance for Inflammatory Bowel Diseases

Daniela Parada Venegas et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Gastroenterology & Hepatology

Efficacy of enteral glutamine supplementation in patients with severe and predicted severe acute pancreatitis- A randomized controlled trial

Madhulika Arutla et al.

INDIAN JOURNAL OF GASTROENTEROLOGY (2019)

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Article Gastroenterology & Hepatology

Gut-liver axis, cirrhosis and portal hypertension: the chicken and the egg

Juan P. Arab et al.

HEPATOLOGY INTERNATIONAL (2018)

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Article Gastroenterology & Hepatology

The bile acids, deoxycholic acid and ursodeoxycholic acid, regulate colonic epithelial wound healing

Magdalena S. Mroz et al.

AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2018)

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Review Infectious Diseases

Gut-origin sepsis in the critically ill patient: pathophysiology and treatment

Stelios F. Assimakopoulos et al.

INFECTION (2018)

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Article Gastroenterology & Hepatology

A Cross-Talk Between Microbiota-Derived Short-Chain Fatty Acids and the Host Mucosal Immune System Regulates Intestinal Homeostasis and Inflammatory Bowel Disease

Pedro Goncalves et al.

INFLAMMATORY BOWEL DISEASES (2018)

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Article Allergy

Neutrophil extracellular traps are associated with disease severity and microbiota diversity in patients with chronic obstructive pulmonary disease

Alison J. Dicker et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2018)

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Review Cell Biology

Gut Microbiota-Immune System Crosstalk and Pancreatic Disorders

D. Pagliari et al.

MEDIATORS OF INFLAMMATION (2018)

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Article Immunology

Identification and Characterization of Blood and Neutrophil-Associated Microbiomes in Patients with Severe Acute Pancreatitis Using Next-Generation Sequencing

Qiurong Li et al.

FRONTIERS IN CELLULAR AND INFECTION MICROBIOLOGY (2018)

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Article Oncology

Regulation of the NLRP3 inflammasome and macrophage pyroptosis by the p38 MAPK signaling pathway in a mouse model of acute lung injury

Dandan Li et al.

MOLECULAR MEDICINE REPORTS (2018)

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Article Critical Care Medicine

Neutrophil extracellular traps (NETs) are increased in the alveolar spaces of patients with ventilator-associated pneumonia

Carmen Mikacenic et al.

CRITICAL CARE (2018)

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Article Medicine, Research & Experimental

Maladaptive role of neutrophil extracellular traps in pathogen-induced lung injury

Emma Lefrancais et al.

JCI INSIGHT (2018)

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Review Immunology

Gut microbiota: Role in pathogen colonization, immune responses, and inflammatory disease

Joseph M. Pickard et al.

IMMUNOLOGICAL REVIEWS (2017)

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Article Biochemistry & Molecular Biology

Combined Delivery of a Lipopolysaccharide-Binding Peptide and the Heme Oxygenase-1 Gene Using Deoxycholic Acid-Conjugated Polyethylenimine for the Treatment of Acute Lung Injury

Ji Yeon Kim et al.

MACROMOLECULAR BIOSCIENCE (2017)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics (ISAPP) consensus statement on the definition and scope of prebiotics

Glenn R. Gibson et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2017)

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Article Gastroenterology & Hepatology

Effect of intestinal epithelial autophagy on bacterial translocation in severe acute pancreatitis

Weiwei Wen et al.

CLINICS AND RESEARCH IN HEPATOLOGY AND GASTROENTEROLOGY (2017)

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Article Cell Biology

Commensal Lactobacillus Controls Immune Tolerance during Acute Liver Injury in Mice

Nobuhiro Nakamoto et al.

CELL REPORTS (2017)

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Article Immunology

Antibiotic-Induced Pathobiont Dissemination Accelerates Mortality in Severe Experimental Pancreatitis

Fernanda S. Soares et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Immunology

Inulin-Type Fructans Modulates PancreaticGut Innate Immune Responses and Gut Barrier Integrity during Experimental Acute Pancreatitis in a Chain Length-Dependent Manner

Yue He et al.

FRONTIERS IN IMMUNOLOGY (2017)

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Article Multidisciplinary Sciences

Dysbiosis of intestinal microbiota and decrease in paneth cell antimicrobial peptide level during acute necrotizing pancreatitis in rats

Jing Chen et al.

PLOS ONE (2017)

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Article Cell Biology

Orai1-Mediated Antimicrobial Secretion from Pancreatic Acini Shapes the Gut Microbiome and Regulates Gut Innate Immunity

Malini Ahuja et al.

CELL METABOLISM (2017)

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Article Critical Care Medicine

Airway Microbiota Determines Innate Cell Inflammatory or Tissue Remodeling Profiles in Lung Transplantation

Eric Bernasconi et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2016)

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Article Gastroenterology & Hepatology

Abdominal Paracentesis Drainage Does Not Bring Extra Risk to Patients With Severe Acute Pancreatitis

Liye Liu et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2016)

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Article Microbiology

Enrichment of the lung microbiome with gut bacteria in sepsis and the acute respiratory distress syndrome

Robert P. Dickson et al.

NATURE MICROBIOLOGY (2016)

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Article Microbiology

Normalization of Host Intestinal Mucus Layers Requires Long-Term Microbial Colonization

Malin E. V. Johansson et al.

CELL HOST & MICROBE (2015)

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Article Critical Care Medicine

Distinct Molecular Phenotypes of Direct vs Indirect ARDS in Single-Center and Multicenter Studies

Carolyn S. Calfee et al.

CHEST (2015)

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Article Nutrition & Dietetics

Early oral refeeding based on hunger in moderate and severe acute pancreatitis: A prospective controlled, randomized clinical trial

Xian L. Zhao et al.

NUTRITION (2015)

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Article Immunology

CD103-CD11b+dendritic cells regulate the sensitivity of CD4 T-cell responses to bacterial flagellin

S. M. Atif et al.

MUCOSAL IMMUNOLOGY (2014)

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Article Gastroenterology & Hepatology

The International Scientific Association for Probiotics and Prebiotics consensus statement on the scope and appropriate use of the term probiotic

Colin Hill et al.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2014)

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Article Multidisciplinary Sciences

Microbial-induced meprin β cleavage in MUC2 mucin and a functional CFTR channel are required to release anchored small intestinal mucus

Andre Schutte et al.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2014)

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Article Gastroenterology & Hepatology

Intravenous infusion of mesenteric lymph from severe intraperitoneal infection rats causes lung injury in healthy

Yan-Min Zhang et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2014)

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Article Biotechnology & Applied Microbiology

In Vitro Comparison of the Effects of Probiotic, Commensal and Pathogenic Strains on Macrophage Polarization

Trine Eker Christoffersen et al.

PROBIOTICS AND ANTIMICROBIAL PROTEINS (2014)

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Review Critical Care Medicine

Use of probiotics in the treatment of severe acute pancreatitis: a systematic review and meta-analysis of randomized controlled trials

Shanmiao Gou et al.

CRITICAL CARE (2014)

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Review Immunology

Intestinal epithelial cells: regulators of barrier function and immune homeostasis

Lance W. Peterson et al.

NATURE REVIEWS IMMUNOLOGY (2014)

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Article Critical Care Medicine

Bacteremia in Patients With Acute Pancreatitis as Revealed by 16S Ribosomal RNA Gene-Based Techniques

Qiurong Li et al.

CRITICAL CARE MEDICINE (2013)

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Review Immunology

Translocation of gut flora and its role in sepsis

C. Vaishnavi

INDIAN JOURNAL OF MEDICAL MICROBIOLOGY (2013)

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Article Gastroenterology & Hepatology

Effects of early enteral nutrition on immune function of severe acute pancreatitis patients

Jia-Kui Sun et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2013)

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Article Multidisciplinary Sciences

Neutrophil Extracellular Traps Directly Induce Epithelial and Endothelial Cell Death: A Predominant Role of Histones

Mona Saffarzadeh et al.

PLOS ONE (2012)

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Article Gastroenterology & Hepatology

Role of Probiotics on Gut Permeability and Endotoxemia in Patients With Acute Pancreatitis A Double-Blind Randomized Controlled Trial

Brij Sharma et al.

JOURNAL OF CLINICAL GASTROENTEROLOGY (2011)

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Review Immunology

Secretory IgA's complex roles in immunity and mucosal homeostasis in the gut

N. J. Mantis et al.

MUCOSAL IMMUNOLOGY (2011)

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Article Critical Care Medicine

Innate Immune Recognition in Infectious and Noninfectious Diseases of the Lung

Bastian Opitz et al.

AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE (2010)

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Article Surgery

Bacterial translocation and infected pancreatic necrosis in acute necrotizing pancreatitis derives from small bowel rather than from colon

Stefan Fritz et al.

AMERICAN JOURNAL OF SURGERY (2010)

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Article Endocrinology & Metabolism

Gut lymph and lymphatics: a source of factors leading to organ injury and dysfunction

Edwin A. Deitch

LYMPHATICS IN THE DIGESTIVE SYSTEM: PHYSIOLOGY, HEALTH, AND DISEASE (2010)

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Article Gastroenterology & Hepatology

Bacterial Translocation to Mesenteric Lymph Nodes Increases in Chronic Portal Hypertensive Rats

Miguel-Angel Llamas et al.

DIGESTIVE DISEASES AND SCIENCES (2010)

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Article Nutrition & Dietetics

Effects of Enteral Immunonutrition on the Maintenance of Gut Barrier Function and Immune Function in Pigs With Severe Acute Pancreatitis

Xiao-Ping Zou et al.

JOURNAL OF PARENTERAL AND ENTERAL NUTRITION (2010)

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Article Surgery

Probiotic Agent Saccharomyces boulardii Reduces the Incidence of Lung Injury in Acute Necrotizing Pancreatitis Induced Rats

Melike Karen et al.

JOURNAL OF SURGICAL RESEARCH (2010)

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Article Cell Biology

Hypoxia-inducible Factor-dependent Regulation of Platelet-activating Factor Receptor as a Route for Gram-Positive Bacterial Translocation across Epithelia

Simon Keely et al.

MOLECULAR BIOLOGY OF THE CELL (2010)

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Article Critical Care Medicine

MICROTHROMBUS FORMATION MAY TRIGGER LUNG INJURY AFTER ACUTE BLOOD LOSS

Robert L. Conhaim et al.

SHOCK (2010)

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Article Nutrition & Dietetics

Protective effect of galactooligosaccharide-supplemented enteral nutrition on intestinal barrier function in rats with severe acute pancreatitis

Yan Zhong et al.

CLINICAL NUTRITION (2009)

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