Development and Verification of a Combined Immune- and Metabolism-Related Prognostic Signature for Hepatocellular Carcinoma

Article Gastroenterology & Hepatology

Clinical Significance of Acylphosphatase 1 Expression in Combined HCC-iCCA, HCC, and iCCA

Yoshihiro Sakano et al.

Summary: High ACYP1 expression could affect the prognosis of cHCC-iCCA, HCC, and iCCA patients. In vitro, ACYP1 expression influences tumor growth and cell viability in both HCC and iCCA by regulating anti-apoptosis proteins.

DIGESTIVE DISEASES AND SCIENCES (2022)

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Review Oncology

Immunotherapies for hepatocellular carcinoma

Josep M. Llovet et al.

Summary: Liver cancer, specifically hepatocellular carcinoma (HCC), is the second leading cause of cancer-related death globally. Traditional treatments involve specific drugs, but the emergence of immune checkpoint inhibitors has revolutionized the management of HCC.

NATURE REVIEWS CLINICAL ONCOLOGY (2022)

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Review Oncology

Improvement of the anticancer efficacy of PD-1/PD-L1 blockade via combination therapy and PD-L1 regulation

Mengling Wu et al.

Summary: PD-1/PD-L1 immune checkpoints inhibit the anticancer effect of T cells in the tumor microenvironment, and downregulation or upregulation of PD-L1 expression can improve the efficacy of anti-PD-1/PD-L1 treatment. Overcoming the current limitations of this treatment can expand its anticancer applications and improve patient response rates and survival time.

JOURNAL OF HEMATOLOGY & ONCOLOGY (2022)

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Article Immunology

The Heterogeneity of Immune Cell Infiltration Landscape and Its Immunotherapeutic Implications in Hepatocellular Carcinoma

Yuanyuan Guo et al.

Summary: Immunotherapy has a low response rate in hepatocellular carcinoma (HCC), but a study revealed that immune infiltration patterns and CTNNB1 mutation status can impact the efficacy of immunotherapy and prognosis in HCC patients. Evaluating immune infiltration patterns can improve understanding of the tumor immune microenvironment and provide new directions for individualized immunotherapy strategies for HCC.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Oncology

An immune-related gene signature for predicting survival and immunotherapy efficacy in hepatocellular carcinoma

Yifei Dai et al.

Summary: A novel immune-related gene signature was developed to accurately predict survival and immunotherapy efficacy for HCC patients. Analysis of HCC samples identified 11 differentially expressed immune-related genes, which were used to establish the IRGPI with high predictive accuracy and ability to reflect the immune microenvironment and predict immunotherapy efficacy.

CANCER IMMUNOLOGY IMMUNOTHERAPY (2021)

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Review Oncology

The Current Landscape of Immune Checkpoint Blockade in Hepatocellular Carcinoma: A Review

Matthias Pinter et al.

Summary: Recent advancements in the treatment of advanced hepatocellular carcinoma (HCC) have led to the approval of new systemic therapies such as angiogenesis inhibitors and immune checkpoint blockers, indicating important progress in the field. Strategies to target immunosuppression in tumors, such as vascular endothelial growth factor pathway inhibition and transforming growth factor-beta pathway inhibition, show promise in enhancing the efficacy of immunotherapy in HCC. Successes and failures of these treatments have provided insights into implementing novel systemic therapy in HCC and improving immunotherapy efficacy for this disease.

JAMA ONCOLOGY (2021)

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Article Microbiology

Adh4, an alcohol dehydrogenase controls alcohol formation within bacterial microcompartments in the acetogenic bacterium Acetobacterium woodii

Nilanjan Pal Chowdhury et al.

Summary: Acetobacterium woodii utilizes the Wood-Ljungdahl pathway for acetate production from CO2, but can also metabolize 1,2-propanediol to produce propionate and propanol. Adh4 in A. woodii is the alcohol dehydrogenase responsible for propanol formation within bacterial microcompartments, playing a crucial role in NADH recycling and redox balancing. Deletion of adh4 gene in A. woodii results in reduced propanol formation and altered metabolic end products.

ENVIRONMENTAL MICROBIOLOGY (2021)

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Article Gastroenterology & Hepatology

Significant down-regulation of growth hormone receptor expression revealed as a new unfavorable prognostic factor in hepatitis C virus-related hepatocellular carcinoma

Ching-Chih Lin et al.

Summary: The study identified a significant down-regulation of GHR expression in HCV-related HCC tissues compared to ANT liver tissues. Lower GHR expression was associated with older age, as well as worse clinicopathologic characteristics, suggesting that decreased GHR expression levels contribute to the development of HCC.

CLINICAL AND MOLECULAR HEPATOLOGY (2021)

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Article Pharmacology & Pharmacy

A novel mechanism underlying alcohol dehydrogenase expression: hsa-miR-148a-3p promotes ADH4 expression via an AGO1-dependent manner in control and ethanol-exposed hepatic cells

Jiao Luo et al.

Summary: The study reveals that key alcohol-metabolizing enzymes are suppressed in patients with alcoholic hepatitis, while miR148a positively regulates ADH4 through a non-canonical mechanism, providing insights into a new regulatory pathway for ADH genes.

BIOCHEMICAL PHARMACOLOGY (2021)

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Article Oncology

Development and Validation of Nomograms to Predict Local, Regional, and Distant Recurrence in Patients With Thin (T1) Melanomas

Mary-Ann El Sharouni et al.

Summary: Although most patients with thin melanomas have a good prognosis, some may experience recurrence. The developed model in this study accurately identifies a subgroup at high risk.

JOURNAL OF CLINICAL ONCOLOGY (2021)

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Article Cell Biology

Identification and Validation of Pyroptosis-Related Gene Signature to Predict Prognosis and Reveal Immune Infiltration in Hepatocellular Carcinoma

Xiao-Wei Fu et al.

Summary: The study revealed that the pyroptosis-related gene signature comprised of GSDME, GPX4, and SCAF11 can serve as an independent prognostic factor for HCC patients, providing further evidence for more clinical and functional studies.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

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Review Gastroenterology & Hepatology

Advances in immunotherapy for hepatocellular carcinoma

Bruno Sangro et al.

Summary: Immunotherapeutic interventions have shown effectiveness in the treatment of hepatocellular carcinoma. Checkpoint inhibitors have demonstrated strong anti-tumor activity, but other immune strategies have not yet shown consistent clinical activity. Advancing treatment to earlier stages, discovering predictive biomarkers, and exploring effective combinatorial approaches are key challenges in HCC immunotherapy.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2021)

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Article Oncology

An Inflammatory Response-Related Gene Signature Can Impact the Immune Status and Predict the Prognosis of Hepatocellular Carcinoma

Zhuo Lin et al.

Summary: Hepatocellular carcinoma (HCC) is a highly heterogeneous disease, and the prognostic prediction is challenging due to its complexity. In this study, a novel prognostic signature consisting of eight inflammatory response-related genes was constructed using LASSO Cox regression analysis. These genes were found to be correlated with overall survival, immune status, cancer-related pathways, and drug sensitivity in HCC patients.

FRONTIERS IN ONCOLOGY (2021)

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Article Oncology

Nomograms to predict outcomes after 177Lu-PSMA therapy in men with metastatic castration-resistant prostate cancer: an international, multicentre, retrospective study

Andrei Gafita et al.

Summary: Nomograms developed in this study can predict outcomes after Lu-177-PSMA in patients with mCRPC. These predictive models can assist in guiding clinical trial design and individual clinical decision-making, especially in institutions where Lu-177-PSMA is introduced as a novel therapeutic option.

LANCET ONCOLOGY (2021)

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Article Medicine, General & Internal

A Five-Gene-Based Prognostic Signature for Hepatocellular Carcinoma

Dazhi Tian et al.

Summary: This study identified potential prognostic marker genes associated with hepatocellular carcinoma (HCC) prognosis through analysis of TCGA and GEO databases. Five core genes (CDC20, TOP2A, RRM2, UBE2C, and AOX1) were significantly linked to HCC patient prognosis, and a risk model based on these genes accurately predicted patient outcomes.

FRONTIERS IN MEDICINE (2021)

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Review Oncology

Cancer metabolism: looking forward

Inmaculada Martinez-Reyes et al.

Summary: This Perspective discusses the main themes in cancer metabolism research, focusing on the relationship between tumour initiation and progression with metabolic reprogramming, as well as the importance of tumor microenvironment and metabolic regulation.

NATURE REVIEWS CANCER (2021)

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Article Infectious Diseases