Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.839291
Keywords
N-6-methyladenosine; hematopoietic stem cell; T cell; B cell; RNA
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Funding
- National Natural Science Foundation of China [82071738]
- Huai'an Tianyixing key Laboratory of Medical Examination [HAP202004]
- Huai'an Natural Science Research Program [HABL202114]
- Medical Leadership Program of Jiangsu College of Nursing [2021001]
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This review introduces the process and regulatory mechanisms of m(6)A modification and its role in controlling HSC generation, differentiation, and the development of immune cells. The evidence suggests that m(6)A modification is a crucial immune system regulator.
RNA, one of the major building blocks of the cell, participates in many essential life processes. RNA stability is well-established to be closely related to various RNA modifications. To date, hundreds of different RNA modifications have been identified. N6-methyladenosine (m(6)A) is one of the most important RNA modifications in mammalian cells. An increasing body of evidence from recently published studies suggests that m(6)A modification is a novel immune system regulator of the generation and differentiation of hematopoietic stem cells (HSCs) and immune cells. In this review, we introduce the process and relevant regulatory mechanisms of m(6)A modification; summarize recent findings of m(6)A in controlling HSC generation and self-renewal, and the development and differentiation of T and B lymphocytes from HSCs; and discuss the potential mechanisms involved.
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