ILC2s expanded by exogenous IL-33 regulate CD45+CD11b+F4/80high macrophage polarization to alleviate hepatic ischemia-reperfusion injury

Article Allergy

Effect of Acinetobacter lwoffii on the modulation of macrophage activation and asthmatic inflammation

Hanbit Kang et al.

Summary: The study showed that intranasal exposure to A. Iwoffii can suppress asthma development by modulating lung macrophage activation, shifting M2a and M2c macrophages to M2b macrophages.

CLINICAL AND EXPERIMENTAL ALLERGY (2022)

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Review Gastroenterology & Hepatology

Liver ischaemia-reperfusion injury: a new understanding of the role of innate immunity

Hirofumi Hirao et al.

Summary: The authors of this Review examine the roles of macrophages, platelets, and neutrophils in liver ischaemia-reperfusion injury (LIRI), discussing potential therapeutic strategies for treating LIRI in transplant recipients. They highlight the unanswered questions in understanding the mechanisms underlying the responses of these cells in the acute phase of LIRI, and discuss prospects for innovative therapeutic regimens against LIRI in transplant recipients.

NATURE REVIEWS GASTROENTEROLOGY & HEPATOLOGY (2022)

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Article Surgery

Role of podoplanin and Kupffer cells in liver injury after ischemia-reperfusion in mice

Yuuki Nakata et al.

Summary: The study investigated the relationship between intrahepatic expression of podoplanin (PDPN) and Kupffer cells (KCs) in ischemia-reperfusion (I/R) liver damage. Results suggest that Kupffer cells play a key role in platelet activation through direct contact with PDPN-positive hepatocytes in I/R livers, and tissue HGF and IGF-1 levels decrease in I/R liver damage.

SURGERY TODAY (2022)

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Review Immunology

Innate Lymphoid Cells in Autoimmune Diseases

Aurelie S. Clottu et al.

Summary: Innate lymphoid cells (ILC) are a group of immune cells similar to T cells in morphology and cytokine profile, but they lack clonally distributed diverse antigen receptors. ILC, especially ILC1, ILC2, and ILC3, express transcription factors and cytokines similar to T helper cells, and play an important role in innate immunity by responding rapidly to pathogens. Recent studies have shown that alterations in the number and function of ILC are associated with autoimmune diseases such as systemic lupus erythematosus, systemic sclerosis, and rheumatoid arthritis.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Immunology

Small Proline-Rich Protein 3 Regulates IL-33/ILC2 Axis to Promote Allergic Airway Inflammation

Guiping Zhu et al.

Summary: This study reveals the regulatory role of SPRR3 in allergic airway inflammation and identifies it as a potential novel therapeutic target for asthma.

FRONTIERS IN IMMUNOLOGY (2022)

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Article Gastroenterology & Hepatology

Mitochondrial bioenergetics boost macrophage activation, promoting liver regeneration in metabolically compromised animals

Naroa Goikoetxea-Usandizaga et al.

Summary: Boosting mitochondrial activity by silencing MCJ could be a protective approach, especially in metabolically compromised organs susceptible to IRI, promoting liver regeneration and reducing cell death.

HEPATOLOGY (2022)

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Article Immunology

Down-regulation of TRPM2 attenuates hepatic ischemia/reperfusion injury through activation of autophagy and inhibition of NLRP3 inflammasome pathway

Tao Zhang et al.

Summary: TRPM2 plays a critical role in hepatic ischemia/reperfusion (I/R) injury and oxygen-glucose deprivation/reoxygenation (OGD/R) induced hepatocyte injury, protecting the liver through activation of autophagy and inhibition of the NLRP3 inflammasome pathway.

INTERNATIONAL IMMUNOPHARMACOLOGY (2022)

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Article Allergy

Effect of Acinetobacter Iwoffii on the modulation of macrophage activation and asthmatic inflammation

Hanbit Kang et al.

Summary: The study demonstrated that Acinetobacter Iwoffii can suppress asthma development by modulating lung macrophage activation and shifting M2a and M2c macrophages to M2b macrophages.

CLINICAL AND EXPERIMENTAL ALLERGY (2022)

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Article Multidisciplinary Sciences

Single-cell transcriptomic analysis reveals the immune landscape of lung in steroid-resistant asthma exacerbation

Lingli Wang et al.

Summary: The study identified key immune cells and pathways involved in asthma exacerbation by establishing a mouse model of LPS-induced steroid-resistant exacerbation on the background of house dust mite-induced asthma. This provides important mechanistic insights for further understanding immune responses during asthma exacerbation.

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2021)

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Article Immunology

Posttranscriptional regulation of ILC2 homeostatic function via tristetraprolin

Yuki Hikichi et al.

Summary: TTP plays a role in regulating cytokine production in ILC2s by promoting the degradation of Il5 mRNA in steady state, while downregulation of TTP under IL-33 stimulation may contribute to excessive cytokine production.

JOURNAL OF EXPERIMENTAL MEDICINE (2021)

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Article Immunology

The NF-κB Transcription Factor c-Rel Modulates Group 2 Innate Lymphoid Cell Effector Functions and Drives Allergic Airway Inflammation

Barbara C. Mindt et al.

Summary: The NF-kappa B subunit c-Rel is crucial for effective innate pulmonary type 2 immune responses, regulated by IL-33-induced expression and nuclear translocation. Intrinsic deficiency of c-Rel in ILC2s does not affect development or homeostatic numbers, but alters activation status and the expression of key stimulatory receptors and type 2 signature cytokines. Rel(-/-) mice suggest that c-Rel promotes acute ILC2-driven allergic airway inflammation, highlighting its potential as a therapeutic target for allergic asthma.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Activation of iNKT Cells Facilitates Liver Repair After Hepatic Ischemia Reperfusion Injury Through Acceleration of Macrophage Polarization

Takuya Goto et al.

Summary: The activation of iNKT cells has been shown to accelerate liver repair by promoting macrophage polarization after hepatic ischemia-reperfusion injury. These findings suggest that iNKT cell activation may serve as a therapeutic strategy for liver repair following liver I/R injury.

FRONTIERS IN IMMUNOLOGY (2021)

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Review Immunology

Tissue-Specific Molecular Markers and Heterogeneity in Type 2 Innate Lymphoid Cells

Enrique Olguin-Martinez et al.

Summary: Innate lymphoid cells (ILCs) are a newly described subgroup of lymphoid cells, showing heterogeneity similar to different groups of T cells. Different types of ILCs have distinct functions in different tissues and express different markers. Among them, ILC2s respond to stimuli like parasites and regulate immune responses.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Gastroenterology & Hepatology

T-Cell Immunoglobulin and Mucin Domain-Containing Protein-4 Is Critical for Kupffer Cell Homeostatic Function in the Activation and Resolution of Liver Ischemia Reperfusion Injury

Ming Ni et al.

Summary: TIM-4 is critical for the homeostatic function of Kupffer cells in both the activation and resolution of liver ischemia reperfusion injury through efferocytosis.

HEPATOLOGY (2021)

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Review Oncology

A crosstalk between type 2 innate lymphoid cells and alternative macrophages in lung development and lung diseases

Lan-Lan Mi et al.

Summary: Type 2 innate lymphoid cells (ILC2s) and M2 macrophages play crucial roles in regulating immune responses, with their crosstalk being vital for lung development and immune anti-inflammatory reactions.

MOLECULAR MEDICINE REPORTS (2021)

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Review Biochemistry & Molecular Biology

The dual function of ILC2: From host protection to pathogenic players in type 2 asthma

Laura Maggi et al.

Summary: ILC2 are considered the innate counterpart of Th2 cells, characterized by the production of type 2 cytokines and expression of GATA-3 transcription factor. They are strategically located in the airway mucosa, playing important roles in patrolling the airways, recruiting other immune cells, and activating resident cells in response to pathogens or tissue damage.

MOLECULAR ASPECTS OF MEDICINE (2021)

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Article Microbiology

Nasal alum-adjuvanted vaccine promotes IL-33 release from alveolar epithelial cells that elicits IgA production via type 2 immune responses

Eita Sasaki et al.

Summary: Aluminum hydroxide salts, commonly known as alum, have been included in inactivated vaccines as adjuvants to enhance vaccination effectiveness. Through the study, it was discovered that alum acts as a potent adjuvant in nasal vaccination by inducing the release of damage-associated molecules in the alveoli, stimulating immune responses. Specifically, the secretion of IL-33 from alveolar epithelial cells through necrosis plays a crucial role in triggering APC- and ILC2-mediated T cell activation, leading to an increase in Ag-specific IgA antibody production facilitated by alum.

PLOS PATHOGENS (2021)

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Article Immunology

Endogenous Interleukin-33 Acts as an Alarmin in Liver Ischemia-Reperfusion and Is Associated With Injury After Human Liver Transplantation

Louise Barbier et al.

Summary: The study found that IL-33 plays a significant role in liver injury, as evidenced by experiments in mouse models and human liver transplant patients.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

IL-33 Drives Expansion of Type 2 Innate Lymphoid Cells and Regulatory T Cells and Protects Mice From Severe, Acute Colitis

Nhi Ngo Thi Phuong et al.

Summary: The IL-33/ST2 pathway plays a crucial protective role in colitis by modulating the numbers of ILC2 and Treg cells, highlighting its potential as a novel therapeutic target in inflammatory bowel disease.

FRONTIERS IN IMMUNOLOGY (2021)

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Article Immunology

Group 2 innate lymphoid cells in bone marrow regulate osteoclastogenesis in a reciprocal manner via RANKL, GM-CSF and IL-13

Yoshiki Momiuchi et al.

Summary: ILC2s in the bone marrow play a crucial role in regulating osteoclast activity and bone homeostasis by expressing RANKL, which can influence the differentiation of osteoclasts from BMMs. Stimulation with IL-7 and IL-33 leads to different effects on RANKL expression and function of ILC2s.

INTERNATIONAL IMMUNOLOGY (2021)

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Article Medicine, Research & Experimental

Autophagic activation of IRF-1 aggravates hepatic ischemia-reperfusion injury via JNK signaling

Shipeng Li et al.

Summary: The study shows that IRF-1 is upregulated in response to hepatic ischemia-reperfusion injury and is associated with autophagic activation, leading to aggravated liver damage. The effects of IRF-1 are linked to JNK pathway activation and increased Beclin1 protein levels, resulting in JNK-induced autophagic cell death and cell failure. These findings suggest that the IRF-1/JNK pathway activates autophagy to worsen liver IRI and may offer new insights into protective therapies.

MEDCOMM (2021)

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Article Immunology

ILC2 Proliferated by IL-33 Stimulation Alleviates Acute Colitis in Rag1-/-Mouse through Promoting M2 Macrophage Polarization

Yong You et al.

JOURNAL OF IMMUNOLOGY RESEARCH (2020)

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Review Immunology

The Heterogeneity, Origins, and Impact of Migratory iILC2 Cells in Anti-helminth Immunity

Mindy M. Miller et al.

FRONTIERS IN IMMUNOLOGY (2020)

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Article Food Science & Technology

Vitamin A deficiency execrates Lewis lung carcinoma via induction of type 2 innate lymphoid cells and alternatively activates macrophages

Weiwei Cui et al.

FOOD SCIENCE & NUTRITION (2019)

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Article Immunology

Group 2 Innate Lymphoid Cells Are Redundant in Experimental Renal Ischemia-Reperfusion Injury

Guy J. M. Cameron et al.

FRONTIERS IN IMMUNOLOGY (2019)

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Article Cell Biology

CD8+ T cell/IL-33/ILC2 axis exacerbates the liver injury in Con A-induced hepatitis in T cell-transferred Rag2-deficient mice

Yuanyue Zhang et al.

INFLAMMATION RESEARCH (2019)

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Article Allergy

Innate immune crosstalk in asthmatic airways: Innate lymphoid cells coordinate polarization of lung macrophages

Jihyun Kim et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2019)

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Article Biochemistry & Molecular Biology

Macrophage-targeting Fasudil treatment protects liver from the ischemia/reperfusion injury by promoting M2 macrophage polarization

Yingli Xie et al.

BIOSCIENCE REPORTS (2018)

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Article Gastroenterology & Hepatology

IL-33 exacerbates liver sterile inflammation by amplifying neutrophil extracellular trap formation

Hamza O. Yazdani et al.

JOURNAL OF HEPATOLOGY (2018)

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Article Urology & Nephrology

Potentiating Tissue-Resident Type 2 Innate Lymphoid Cells by IL-33 to Prevent Renal Ischemia-Reperfusion Injury

Qi Cao et al.

JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY (2018)

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Review Immunology

Dual Effect of Hepatic Macrophages on Liver Ischemia and Reperfusion Injury during Liver Transplantation

Tian-Fei Lu et al.

IMMUNE NETWORK (2018)

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Review Immunology

The group 2 innate lymphoid cell (ILC2) regulatory network and its underlying mechanisms

Hiroki Kabata et al.

IMMUNOLOGICAL REVIEWS (2018)

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Review Immunology

The Pleiotropic Immunomodulatory Functions of IL-33 and Its Implications in Tumor Immunity

Claudia Afferni et al.

FRONTIERS IN IMMUNOLOGY (2018)

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Hepatic Ischemia/Reperfusion: Mechanisms of Tissue Injury, Repair, and Regeneration

Takanori Konishi et al.

GENE EXPRESSION (2017)

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Article Allergy

IL-4 production by group 2 innate lymphoid cells promotes food allergy by blocking regulatory T-cell function

Magali Noval Rivas et al.

JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY (2016)

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Article Gastroenterology & Hepatology

MicroRNA-17 Regulates Autophagy to Promote Hepatic Ischemia/Reperfusion Injury Via Suppression of Signal Transductions and Activation of Transcription-3 Expression

Shipeng Li et al.

LIVER TRANSPLANTATION (2016)

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Article Gastroenterology & Hepatology

miR-30b inhibits autophagy to alleviate hepatic ischemia-reperfusion injury via decreasing the Atg12-Atg5 conjugate

Shi-Peng Li et al.

WORLD JOURNAL OF GASTROENTEROLOGY (2016)

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Review Immunology

Interleukin-33 in health and disease

Foo Yew Liew et al.

NATURE REVIEWS IMMUNOLOGY (2016)

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Article Immunology

IL-25-responsive, lineage-negative KLRG1hi cells are multipotential 'inflammatory' type 2 innate lymphoid cells

Yuefeng Huang et al.

NATURE IMMUNOLOGY (2015)

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Article Immunology

Myeloid PTEN Deficiency Protects Livers from Ischemia Reperfusion Injury by Facilitating M2 Macrophage Differentiation

Shi Yue et al.

JOURNAL OF IMMUNOLOGY (2014)

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Article Immunology

A role for IL-25 and IL-33-driven type-2 innate lymphoid cells in atopic dermatitis

Maryam Salimi et al.

JOURNAL OF EXPERIMENTAL MEDICINE (2013)

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Article Medicine, General & Internal

Pretreatment with interleukin-33 reduces warm hepatic ischemia/reperfusion injury in mice

Li Shu et al.

CHINESE MEDICAL JOURNAL (2013)

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Article Gastroenterology & Hepatology

Interleukin-33 Is hepatoprotective during liver ischemia/reperfusion in mice

Nozomu Sakai et al.

HEPATOLOGY (2012)

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Article Gastroenterology & Hepatology

Programmed Death-1/B7-H1 Negative Costimulation Protects Mouse Liver Against Ischemia and Reperfusion Injury

Haofeng Ji et al.

HEPATOLOGY (2010)

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Review Gastroenterology & Hepatology

Autophagy in liver diseases

Pierre-Emmanuel Rautou et al.

JOURNAL OF HEPATOLOGY (2010)

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Article Immunology

IL-33 Prolongs Murine Cardiac Allograft Survival Through Induction of TH2-Type Immune Deviation

Hui Yin et al.

TRANSPLANTATION (2010)

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Article Immunology

The pro-Th2 cytokine IL-33 directly interacts with invariant NKT and NK cells to induce IFN-γ production

Elvire Bourgeois et al.

EUROPEAN JOURNAL OF IMMUNOLOGY (2009)

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Article Biotechnology & Applied Microbiology

Tissue-resident Macrophages Protect the Liver From Ischemia Reperfusion Injury via a Heme Oxygenase-1-Dependent Mechanism

Luke Devey et al.

MOLECULAR THERAPY (2009)

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Review Immunology

Exploring the full spectrum of macrophage activation

David M. Mosser et al.

NATURE REVIEWS IMMUNOLOGY (2008)

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ILC2s expanded by exogenous IL-33 regulate CD45+CD11b+F4/80high macrophage polarization to alleviate hepatic ischemia-reperfusion injury

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