Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.940929
Keywords
Trachinotus ovatus; Oedocladium carolinanum; antioxidant status; growth performance; immunity; histomorphology
Categories
Funding
- Project of the National Natural Science Foundation of China [31872580, 32172982]
- Project of the Science and Technology of Guangdong Province [2019B110209005]
- Guangdong Provincial Special Fund for Morden Agriculture Industry Technology Innovation Teams [2019KJ143]
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This study assessed the feasibility of using astaxanthin-rich Oedocladium carolinianum as an immunostimulant in the diet for Trachinotus ovatus. The results showed that a diet supplemented with 5% O. carolinianum improved the growth performance, antioxidant capacity, and immune response of T. ovatus.
The purpose of this study is to assess the feasibility of astaxanthin-rich Oedocladium carolinianum as an immunostimulant in the diet for Trachinotus ovatus. Three experimental diets containing 0% (OC0), 1% (OC1), and 5% (OC5) O. carolinianum powder were formulated for 6-week feeding trials. The results indicated that the OC5 diet boosted the growth performance through decreasing the feed conversion ratio and increasing digestive enzyme activities and intestinal villus length. Meanwhile, fish fed with the OC5 diet promoted antioxidant ability via stimulating the Nrf2-ARE signal pathway and enhancing antioxidant enzyme activities. Furthermore, the OC5 diet exerted hepatoprotective effects by suppressing the lipid deposition and inflammation response and enhancing the transport capacity of cholesterol. Besides, the OC5 diet improved the non-specific immunity by activating the lysozyme and complement system and increasing the nitric oxide content and total nitric oxide synthase activity. Dietary O. carolinianum supplementation promoted the deposition of astaxanthin in the whole body. Therefore, a diet supplemented with 5% O. carolinianum is recommended to boost the growth, antioxidant capacity, immune response, and flesh quality of T. ovatus.
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