Case Report: Comorbid Hyper-IgD Syndrome and Hidradenitis Suppurativa - A New Syndromic Form of HS? A Report of Two Cases

Article Dermatology

Whole-Exome Sequencing in 10 Unrelated Patients with Syndromic Hidradenitis Suppurativa: A Preliminary Step for a Genotype-Phenotype Correlation

Angelo Valerio Marzano et al.

Summary: Syndromic hidradenitis suppurativa (HS), an immune-mediated condition associated with systemic comorbidities, is a genetic disease that has not been completely understood. This study used whole-exome sequencing to identify genetic variants associated with different clinical features of syndromic HS. The findings suggest that syndromic HS can be considered as a polygenic autoinflammatory condition.

DERMATOLOGY (2022)

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Review Dermatology

Identification of Biomarkers and Critical Evaluation of Biomarker Validation in Hidradenitis Suppurativa A Systematic Review

Samuel Der Sarkissian et al.

Summary: This study systematically identified and evaluated the existing knowledge of biomarkers in hidradenitis suppurativa (HS). The findings showed that none of the identified biomarkers had sufficient clinical validity to be recommended for routine use in clinical practice. Standardization of goals and methods, as well as the integration of biomarkers into clinical trials, are important priorities for the management of HS.

JAMA DERMATOLOGY (2022)

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Article Dermatology

PASH, PAPASH, PsAPASH, and PASS: The autoinflammatory syndromes of hidradenitis suppurativa

Simone Garcovich et al.

Summary: Hidradenitis suppurativa (HS) is a chronic inflammatory disease involving skin folds, with complex pathogenesis and diverse clinical manifestations. Syndromic HS patients have severe disease, systemic inflammation, and resistance to conventional treatments. Treatment should be personalized, and classification criteria are constantly evolving.

CLINICS IN DERMATOLOGY (2021)

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Review Dermatology

Prevalence of Hidradenitis Suppurativa A Systematic Review and Meta-regression Analysis

Abdulhadi Jfri et al.

Summary: The prevalence of hidradenitis suppurativa (HS) was estimated to be 0.40% in the overall population, with clinical samples showing a higher prevalence (1.7%) compared to population-based studies (0.3%). These findings can aid in policy formulation and guiding principles for better disease diagnosis.

JAMA DERMATOLOGY (2021)

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Review Immunology