4.8 Article

Bacterial extracellular vesicles control murine norovirus infection through modulation of antiviral immune responses

Related references

Note: Only part of the references are listed.
Article Cell Biology

Extracellular vesicles produced by the human commensal gut bacterium Bacteroides thetaiotaomicron affect host immune pathways in a cell-type specific manner that are altered in inflammatory bowel disease

Lejla Gul et al.

Summary: The gastrointestinal tract houses a complex microbial community that plays a crucial role in maintaining gut health. This study investigates the interactions between bacterial extracellular vesicles (BEVs) released by a gut commensal bacterium and host immune cells, revealing that the communication between BEVs and the host is influenced by both cell type and health status. The findings provide insights into potential BEV-based therapies for treating inflammatory bowel disease.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Article Cell Biology

Interaction with mammalian enteric viruses alters outer membrane vesicle production and content by commensal bacteria

Chanel A. Mosby et al.

Summary: This article demonstrates for the first time that enteric viruses can alter gene expression and phenotype of commensal bacteria, leading to increased production of smaller outer membrane vesicles. The interaction between viruses and bacteria may have broad implications.

JOURNAL OF EXTRACELLULAR VESICLES (2022)

Article Immunology

The gut microbiota prime systemic antiviral immunity via the cGAS-STING-IFN-I axis

Saskia F. Erttmann et al.

Summary: This study revealed the modulation of systemic immunity and response to viral infection by gut commensals. Peripheral cGAS-STING activation plays a crucial role in promoting host resistance to systemic viral infections.

IMMUNITY (2022)

Article Immunology

Pretreatment of outer membrane vesicle and subsequent infection with influenza virus induces a long-lasting adaptive immune response against broad subtypes of influenza virus

Chang-Ung Kim et al.

Summary: This study demonstrates that consecutive administration of modified outer membrane vesicle (fmOMV) and influenza virus can induce broad and long-lasting protective immunity against various virus subtypes.

MICROBES AND INFECTION (2022)

Review Biotechnology & Applied Microbiology

Extracellular vesicles of bacteria as potential targets for immune interventions

Yizhi Peng et al.

Summary: Bacterial infection-induced extracellular vesicles (EVs) have become a significant research focus in recent years, with potential not only in physiological and pathological processes, but also as candidates for new vaccines. A deeper understanding of the interaction between EVs and the immune system can facilitate the application and development of EVs.

HUMAN VACCINES & IMMUNOTHERAPEUTICS (2021)

Article Biochemical Research Methods

Characterization and proteomic analysis of outer membrane vesicles from a commensal microbe, Enterobacter cloacae

Sutonuka Bhar et al.

Summary: This study characterized the proteome of E. cloacae OMVs, revealing the presence of membrane-bound proteins and providing insight into their functional role. The research also discovered that this bacterium uses two mechanisms for OMV production. Further exploration of membrane vesicles produced by commensal bacteria and their role in cell-to-cell communication is encouraged.

JOURNAL OF PROTEOMICS (2021)

Article Multidisciplinary Sciences

Real-time tracking of bacterial membrane vesicles reveals enhanced membrane traffic upon antibiotic exposure

Julia Bos et al.

Summary: Membrane vesicles are common carriers of molecular information and primarily disperse along bacterial surfaces. When bacteria are challenged with low doses of antibiotics, vesicle production and movement are significantly enhanced, independent of cell clustering but associated with a reduction in surface appendage density.

SCIENCE ADVANCES (2021)

Article Pharmacology & Pharmacy

Bacterial-Derived Outer Membrane Vesicles are Potent Adjuvants that Drive Humoral and Cellular Immune Responses

J. Timothy Prior et al.

Summary: OMVs have the potential to function as a stand-alone adjuvant, driving stronger immune responses compared to heat-inactivated and live-attenuated bacteria. They induce robust humoral and cellular immune responses, generating stronger antibody and B cell responses than traditional adjuvants, while remaining unaffected by pre-existing antibodies.

PHARMACEUTICS (2021)

Article Microbiology

Fusobacterium nucleatum Secretes Outer Membrane Vesicles and Promotes Intestinal Inflammation

Melinda A. Engevik et al.

Summary: The study demonstrates that Fusobacterium nucleatum can promote intestinal inflammation by activating Toll-like receptor 4 and NF-KB, leading to disruption of colonic architecture, immune cell infiltration, and increased levels of proinflammatory cytokines. The findings suggest a potential mechanism by which F. nucleatum contributes to intestinal inflammation in the context of a depleted gut microbiome.
Review Immunology

Host immunity and cellular responses to bacterial outer membrane vesicles

Varnesh Tiku et al.

Summary: Outer membrane vesicles (OMVs) produced by Gram-negative bacteria play crucial roles in various aspects of bacterial physiology and their interaction with vertebrate host cells. They are important for bacterial colonization, delivery of virulence factors, and disease pathogenesis. OMVs also help bacteria modulate host immune responses, aiding in their evasion of host immunity.

TRENDS IN IMMUNOLOGY (2021)

Review Virology

Microbiota-immune system interactions and enteric virus infection

Mikal A. Woods Acevedo et al.

Summary: Enteric viruses are significant human pathogens that infect the gastrointestinal tract, where the microbiota play a crucial role in their replication, pathogenesis, and transmission. The abundance and composition of the microbiota are also important for the host immune system, which may impact the infection of enteric viruses.

CURRENT OPINION IN VIROLOGY (2021)

Article Immunology

Burkholderia pseudomallei OMVs derived from infection mimicking conditions elicit similar protection to a live-attenuated vaccine

Sarah M. Baker et al.

Summary: Burkholderia pseudomallei OMVs produced under macrophage-mimicking growth conditions (M9 OMVs) contain proteins associated with intracellular survival, provide significant protection against pulmonary infection in mice, possess adjuvanticity, and may serve as a promising vaccine against melioidosis.

NPJ VACCINES (2021)

Article Gastroenterology & Hepatology

cGAS-STING effectively restricts murine norovirus infection but antagonizes the antiviral action of N-terminus of RIG-I in mouse macrophages

Peifa Yu et al.

Summary: Our study revealed that STING agonists effectively inhibit MNV replication in mouse macrophages, partly through the JAK/STAT pathway, while both cGAS and STING are essential for host defense against MNV propagation. Interestingly, STING interacts with mouse RIG-I and attenuates its anti-MNV effects, highlighting the crucial role of cGAS and STING in regulating innate immune response and defending against RNA virus infections.

GUT MICROBES (2021)

Review Biochemistry & Molecular Biology

Host- and Microbiota-Derived Extracellular Vesicles, Immune Function, and Disease Development

Laurence Macia et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Review Microbiology

Cracking Open Bacterial Membrane Vesicles

Toshiki Nagakubo et al.

FRONTIERS IN MICROBIOLOGY (2020)

Article Virology

Vero Cells as a Mammalian Cell Substrate for Human Norovirus

Kyle V. Todd et al.

VIRUSES-BASEL (2020)

Review Biochemistry & Molecular Biology

OMV Vaccines and the Role of TLR Agonists in Immune Response

Francesca Mancini et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Article Virology

Attach Me If You Can: Murine Norovirus Binds to Commensal Bacteria and Fungi

Jasmine L. Madrigal et al.

VIRUSES-BASEL (2020)

Review Microbiology

Membrane Vesicle Production as a Bacterial Defense Against Stress

Negar Mozaheb et al.

FRONTIERS IN MICROBIOLOGY (2020)

Review Nanoscience & Nanotechnology

Outer membrane vesicles for vaccination and targeted drug delivery

Sihan Wang et al.

WILEY INTERDISCIPLINARY REVIEWS-NANOMEDICINE AND NANOBIOTECHNOLOGY (2019)

Review Immunology

The Commensal Microbiota and Viral Infection: A Comprehensive Review

Na Li et al.

FRONTIERS IN IMMUNOLOGY (2019)

Review Biochemistry & Molecular Biology

The Role of Interferon in Persistent Viral Infection: Insights from Murine Norovirus

Timothy J. Nice et al.

TRENDS IN MICROBIOLOGY (2018)

Review Biochemistry & Molecular Biology

Fantastic voyage: the journey of intestinal microbiota-derived microvesicles through the body

Regis Stentz et al.

BIOCHEMICAL SOCIETY TRANSACTIONS (2018)

Article Multidisciplinary Sciences

Human norovirus binding to select bacteria representative of the human gut microbiota

Erin A. Almand et al.

PLOS ONE (2017)

Article Biotechnology & Applied Microbiology

Detection of human norovirus in intestinal biopsies from immunocompromised transplant patients

Umesh C. Karandikar et al.

JOURNAL OF GENERAL VIROLOGY (2016)

Review Microbiology

The influence of commensal bacteria on infection with enteric viruses

Stephanie M. Karst

NATURE REVIEWS MICROBIOLOGY (2016)

Article Multidisciplinary Sciences

Replication of human noroviruses in stem cell-derived human enteroids

Khalil Ettayebi et al.

SCIENCE (2016)

Review Biochemistry & Molecular Biology

Norovirus Regulation by Host and Microbe

Megan T. Baldridge et al.

TRENDS IN MOLECULAR MEDICINE (2016)

Article Biochemistry & Molecular Biology

Murine Norovirus 1 (MNV1) Replication Induces Translational Control of the Host by Regulating eIF4E Activity during Infection

Elizabeth Royall et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2015)

Article Multidisciplinary Sciences

Commensal microbes and interferon-λ determine persistence of enteric murine norovirus infection

Megan T. Baldridge et al.

SCIENCE (2015)

Review Immunology

Immune modulation by bacterial outer membrane vesicles

Maria Kaparakis-Liaskos et al.

NATURE REVIEWS IMMUNOLOGY (2015)

Article Multidisciplinary Sciences

Enteric bacteria promote human and mouse norovirus infection of B cells

Melissa K. Jones et al.

SCIENCE (2014)

Article Immunology

Assessment of mOMV adjuvant efficacy in the pathogenic H1N1 influenza virus vaccine

Byeong-Jae Lee et al.

CLINICAL AND EXPERIMENTAL VACCINE RESEARCH (2014)

Review Multidisciplinary Sciences

Host-Gut Microbiota Metabolic Interactions

Jeremy K. Nicholson et al.

SCIENCE (2012)

Review Immunology

Bacterial outer membrane vesicles in disease and preventive medicine

Can M. Unal et al.

SEMINARS IN IMMUNOPATHOLOGY (2011)

Article Virology

Type I and Type II Interferons Inhibit the Translation of Murine Norovirus Proteins

Harish Changotra et al.

JOURNAL OF VIROLOGY (2009)

Article Immunology

Norwalk virus shedding after experimental human infection

Robert L. Atmar et al.

EMERGING INFECTIOUS DISEASES (2008)

Article Multidisciplinary Sciences

STAT1-dependent innate immunity to a Norwalk-like virus

SM Karst et al.

SCIENCE (2003)