Journal
FRONTIERS IN IMMUNOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fimmu.2022.922377
Keywords
neutrophil; malaria; plasmodium; salmonella typhimurium; neutrophil extracellular traps (NETs)
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Funding
- Jubilee Foundation of the Swiss Life Insurance
- Pension Fund for Public Health and Medical Research
- Swiss National funding [P500PB_203002]
- Swiss National Science Foundation (SNF) [P500PB_203002] Funding Source: Swiss National Science Foundation (SNF)
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Neutrophils play an important role in malaria, both in the defense against the malaria parasite and in the pathogenesis of the disease. However, malaria parasites inhibit the antimicrobial function of neutrophils, which may make malaria patients more susceptible to bacterial infections.
Neutrophils are the most abundant leukocytes in human peripheral blood. They form the first line of defense against invading foreign pathogens and might play a crucial role in malaria. According to World Health Organization (WHO), malaria is a globally significant disease caused by protozoan parasites from the Plasmodium genus, and it's responsible for 627,000 deaths in 2020. Neutrophils participate in the defense response against the malaria parasite via phagocytosis and reactive oxygen species (ROS) production. Neutrophils might also be involved in the pathogenesis of malaria by the release of toxic granules and the release of neutrophil extracellular traps (NETs). Intriguingly, malaria parasites inhibit the anti-microbial function of neutrophils, thus making malaria patients more susceptible to secondary opportunistic Salmonella infections. In this review, we will provide a summary of the role of neutrophils during malaria infection, some contradicting mouse model neutrophil data and neutrophil-related mechanisms involved in malaria patients' susceptibility to bacterial infection.
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