4.8 Article

Dynamic Metabolic Changes During Prolonged Ex Situ Heart Perfusion Are Associated With Myocardial Functional Decline

Related references

Note: Only part of the references are listed.
Article Cardiac & Cardiovascular Systems

Novel heat shock protein 90 inhibitor improves cardiac recovery in a rodent model of donation after circulatory death

Henry Aceros et al.

Summary: This study investigates the use of a HSP90 inhibitor as a cardioprotective agent in DCD hearts, showing promising results in preserving ventricular function and reducing ischemic injury. These findings suggest that HSP90i could potentially expand the use of DCD hearts and improve organ availability for transplantation.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2022)

Review Biochemistry & Molecular Biology

A review of myocardial ischaemia/reperfusion injury: Pathophysiology, experimental models, biomarkers, genetics and pharmacological treatment

Mehmet Gunata et al.

Summary: Cardiovascular diseases are the most fatal worldwide, with ischaemia/reperfusion injury being central to the pathology. Myocardial I/R injury may lead to cardiomyocyte death and affect other cell types. Polymorphonuclear leukocytes are associated with myocardial I/R damage during reperfusion, and optimal cardioprotection may require a combination of multi-target treatments.

CELL BIOCHEMISTRY AND FUNCTION (2021)

Article Cardiac & Cardiovascular Systems

A Novel Rat Model of Cardiac Donation After Circulatory Death Combined With Normothermic ex situ Heart Perfusion

Jiale Li et al.

Summary: The research team successfully established a reliable and economical rat model of DCD protocol combined with normothermic ESHP, finding that DCD hearts can maintain a stable state during 90 minutes of ESHP.

FRONTIERS IN CARDIOVASCULAR MEDICINE (2021)

Article Pharmacology & Pharmacy

Solid phase microextraction chemical biopsy tool for monitoring of doxorubicin residue during in vivo lung chemo-perfusion

Barbara Bojko et al.

Summary: The novel IVLP procedure allows localized high-dose DOX delivery while requiring careful monitoring of drug levels; Bio-SPME can extract DOX and its metabolites for real-time monitoring during procedures. This approach provides insight into tissue concentrations and metabolic features for personalized treatment strategies.

JOURNAL OF PHARMACEUTICAL ANALYSIS (2021)

Article Biochemical Research Methods

Assessment of solid phase microextraction as a sample preparation tool for untargeted analysis of brain tissue using liquid chromatography-mass spectrometry

Nathaly Reyes-Garces et al.

Summary: This study evaluated SPME in combination with LC-HRMS as an analytical approach for untargeted brain analysis. The tested coating chemistries provided comparable brain tissue information, with some coatings showing higher relative standard deviations. Methanol was found to be essential for effective desorption of non-polar metabolites.

JOURNAL OF CHROMATOGRAPHY A (2021)

Article Cardiac & Cardiovascular Systems

Use of metabolomics to identify strategies to improve and prolong ex vivo lung perfusion for lung transplants

Jason Shin et al.

Summary: By studying the dynamic metabolic changes of lungs during EVLP, it was found that energy substrate consumption decreased, fatty acid oxidation increased, protein and nucleotide catabolism increased, and cell membrane remodeling occurred at EVLP-4h. Strategies to supplement nutrients and maintain homeostasis are crucial for improving EVLP protocols and increasing donor lung utilization.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2021)

Review Biochemistry & Molecular Biology

Metabolism pathways of arachidonic acids: mechanisms and potential therapeutic targets

Bei Wang et al.

Summary: The arachidonic acid (AA) pathway is crucial in cardiovascular biology, carcinogenesis, and various inflammatory diseases, producing bioactive mediators that are potential targets for cardiovascular diseases, cancers, and inflammatory diseases. This review summarizes the physiological and pathophysiological importance of AA metabolizing pathways, as well as the molecular mechanisms underlying its actions in CVD and cancer progression. Additionally, clinical studies targeting AA metabolisms in different disease conditions are introduced to explore the role of AA metabolism and potential therapies.

SIGNAL TRANSDUCTION AND TARGETED THERAPY (2021)

Article Cardiac & Cardiovascular Systems

Immunity and Stress Responses Are Induced During Ex Situ Heart Perfusion

Sanaz Hatami et al.

CIRCULATION-HEART FAILURE (2020)

Article Cardiac & Cardiovascular Systems

A 5-year single-center early experience of heart transplantation from donation after circulatory-determined death donors

Simon Messer et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2020)

Article Cardiac & Cardiovascular Systems

Recipient hypertonic saline infusion prevents cardiac allograft dysfunction

Roberto V. P. Ribeiro et al.

JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY (2019)

Article Cardiac & Cardiovascular Systems

Myocardial Functional Decline During Prolonged Ex Situ Heart Perfusion

Sanaz Hatami et al.

ANNALS OF THORACIC SURGERY (2019)

Editorial Material Critical Care Medicine

Ex vivo perfusion techniques: state of the art and potential applications

Marcelo Cypel et al.

INTENSIVE CARE MEDICINE (2019)

Meeting Abstract Cardiac & Cardiovascular Systems

Metabolic Alterations in Myocardial Metabolism during Ex Situ Heart Perfusion

S. Hatami et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

Meeting Abstract Cardiac & Cardiovascular Systems

The Evaluation of Coronary Artery Function during Normothermic Ex Situ Heart Perfusion

X. Qi et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2019)

Article Cardiac & Cardiovascular Systems

Evidence of aldosterone synthesis in human myocardium in acute myocarditis

Andrea Cardona et al.

INTERNATIONAL JOURNAL OF CARDIOLOGY (2019)

Article Biochemistry & Molecular Biology

Docosahexaenoic acid lowers cardiac mitochondrial enzyme activity by replacing linoleic acid in the phospholipidome

E. Madison Sullivan et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2018)

Article Health Care Sciences & Services

A New Multi-Mode Perfusion System for Ex Vivo Heart Perfusion Study

Liming Xin et al.

JOURNAL OF MEDICAL SYSTEMS (2018)

Review Medicine, Research & Experimental

Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

Charles N. Serhan et al.

JOURNAL OF CLINICAL INVESTIGATION (2018)

Review Chemistry, Analytical

Advances in Solid Phase Microextraction and Perspective on Future Directions

Nathaly Reyes-Garces et al.

ANALYTICAL CHEMISTRY (2018)

Letter Biochemical Research Methods

Systems biology guided by XCMS Online metabolomics

Tao Huan et al.

NATURE METHODS (2017)

Review Cardiac & Cardiovascular Systems

Choosing the right heart: proper donor selection in cardiac transplantation

Nikhil Bassi et al.

CURRENT OPINION IN CARDIOLOGY (2017)

Article Chemistry, Analytical

xMSannotator: An R Package for Network-Based Annotation of High-Resolution Metabolomics Data

Karan Uppal et al.

ANALYTICAL CHEMISTRY (2017)

Editorial Material Cardiac & Cardiovascular Systems

Evolving Concepts of Myocardial Energy Metabolism More Than Just Fats and Carbohydrates

Gary D. Lopaschuk et al.

CIRCULATION RESEARCH (2016)

Article Cardiac & Cardiovascular Systems

Lipid Use and Misuse by the Heart

P. Christian Schulze et al.

CIRCULATION RESEARCH (2016)

Article Multidisciplinary Sciences

Metabolic profiling during ex vivo machine perfusion of the human liver

Bote G. Bruinsma et al.

SCIENTIFIC REPORTS (2016)

Article Cardiac & Cardiovascular Systems

A whole blood based perfusate provides superior preservation of myocardial function during ex vivo heart perfusion

Christopher W. White et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2015)

Article Cell Biology

Identification and signature profiles for pro-resolving and inflammatory lipid mediators in human tissue

Romain A. Colas et al.

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY (2014)

Article Surgery

Increasing the Tolerance of DCD Hearts to Warm Ischemia by Pharmacological Postconditioning

A. Iyer et al.

AMERICAN JOURNAL OF TRANSPLANTATION (2014)

Article Cardiac & Cardiovascular Systems

Evaluation of the Organ Care System in Heart Transplantation With an Adverse Donor/Recipient Profile

Diana Garcia Saez et al.

ANNALS OF THORACIC SURGERY (2014)

Article Cardiac & Cardiovascular Systems

Donor evaluation in heart transplantation: The end of the beginning

Evan P. Kransdorf et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2014)

Article Cardiac & Cardiovascular Systems

Report from a consensus conference on primary graft dysfunction after cardiac transplantation

Jon Kobashigawa et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2014)

Review Multidisciplinary Sciences

Pro-resolving lipid mediators are leads for resolution physiology

Charles N. Serhan

NATURE (2014)

Article Biochemical Research Methods

Global metabolic profiling of animal and human tissues via UPLC-MS

Elizabeth J. Want et al.

NATURE PROTOCOLS (2013)

Review Cardiac & Cardiovascular Systems

Nitric oxide synthases: regulation and function

Ulrich Foerstermann et al.

EUROPEAN HEART JOURNAL (2012)

Letter Biotechnology & Applied Microbiology

A cross-platform toolkit for mass spectrometry and proteomics

Matthew C. Chambers et al.

NATURE BIOTECHNOLOGY (2012)

Review Cardiac & Cardiovascular Systems

Systems-based approaches to cardiovascular disease

W. Robb MacLellan et al.

NATURE REVIEWS CARDIOLOGY (2012)

Review Biochemistry & Molecular Biology

Fatty acid omega-oxidation as a rescue pathway for fatty acid oxidation disorders in humans

Ronald J. A. Wanders et al.

FEBS JOURNAL (2011)

Article Medicine, General & Internal

Normothermic Ex Vivo Lung Perfusion in Clinical Lung Transplantation

Marcelo Cypel et al.

NEW ENGLAND JOURNAL OF MEDICINE (2011)

Review Cardiac & Cardiovascular Systems

The no-reflow phenomenon: A basic mechanism of myocardial ischemia and reperfusion

Thorsten Reffelmann et al.

BASIC RESEARCH IN CARDIOLOGY (2006)

Article Cardiac & Cardiovascular Systems

Does heart transplantation confer survival benefit in all risk groups?

H Luckraz et al.

JOURNAL OF HEART AND LUNG TRANSPLANTATION (2005)