Journal
APPLIED SCIENCES-BASEL
Volume 12, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/app12157865
Keywords
carbon nanoparticles; graphene; MWCNT; biomedical applications; diagnostic; therapy
Categories
Funding
- ERDF-Project NANOBIO [CZ.02.1.01/0.0/0.0/17_048/0007421]
- Cooperation Program, research area HEAS
- Charles University [SVV 260543/2020]
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This review summarizes the current and future applications of carbon nanoparticles in medicine. Carbon nanoparticles, such as graphene, graphene oxide, and carbon nanotubes, have unique physicochemical properties that make them suitable for clinical use. They are mainly used in medical diagnostics, including bioimaging and chemical/metabolite detection. However, their use in therapeutics, regenerative medicine, and vaccine production is still under research due to nanoparticle toxicity concerns. Preclinical studies show great potential for diagnosis and treatment, but caution is needed before their routine clinical use.
This review summarizes the current knowledge on current and future applications of carbon nanoparticles in medicine. The carbon nanoparticle family has a large number of representatives with unique physicochemical properties that make them good candidates for use in clinical medicine. The best-known (and most researched) carbon nanoparticles include graphene, graphene oxide, and carbon nanotubes. The main direction of use involves medical diagnostics, which includes bioimaging and the detection of chemicals or metabolites present in the body. Since the question of nanoparticle toxicity has not been fully answered, the use of nanoparticles in the fields of therapeutics (drug delivery), regenerative medicine (cell scaffolding, tissue engineering), and vaccine production is still under research and many in vivo studies are ongoing. These preclinical studies suggest that carbon nanoparticles have great potential for diagnosis and treatment; the results show that the nanoparticles used do not have significant toxic effects; however, great caution is needed before nanoparticles are introduced into routine clinical practice.
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