Journal
ANNUAL REVIEW OF VIROLOGY
Volume 9, Issue -, Pages 261-284Publisher
ANNUAL REVIEWS
DOI: 10.1146/annurev-virology-020922-110929
Keywords
-
Categories
Funding
- Deutsche Forschungsgemeinschaft (DFG, German Research Foundation) [240245660]
- TTU HIV in the DZIF
Ask authors/readers for more resources
Recent evidence suggests that reverse transcription and viral genome uncoating of HIV-1 occur in the nucleus rather than the cytoplasm. The cone-shaped capsid may play a crucial role in nuclear import of HIV-1. Rupture of the capsid may be triggered by completion of reverse transcription, nuclear factors, or physical damage, and is closely associated with the integration process.
After cell entry, human immunodeficiency virus type 1 (HIV-1) replication involves reverse transcription of the RNA genome, nuclear import of the subviral complex without nuclear envelope breakdown, and integration of the viral complementary DNA into the host genome. Here, we discuss recent evidence indicating that completion of reverse transcription and viral genome uncoating occur in the nucleus rather than in the cytoplasm, as previously thought, and suggest a testable model for nuclear import and uncoating. Multiple recent studies indicated that the cone-shaped capsid, which encases the genome and replication proteins, not only serves as a reaction container for reverse transcription and as a shield from innate immune sensors but also may constitute the elusive HIV-1 nuclear import factor. Rupture of the capsid may be triggered in the nucleus by completion of reverse transcription, by yet-unknown nuclear factors, or by physical damage, and it appears to occur in close temporal and spatial association with the integration process.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available