4.8 Article

Inhaled Pro-Efferocytic Nanozymes Promote Resolution of Acute Lung Injury

Journal

ADVANCED SCIENCE
Volume 9, Issue 26, Pages -

Publisher

WILEY
DOI: 10.1002/advs.202201696

Keywords

acute lung injury; antioxidant nanozyme; apoptotic cell membrane; efferocytosis; macrophage polarization

Funding

  1. National Natural Science Foundation of China [81974292]
  2. Key Program of Shanghai Committee of Science and Technology [18411951200]
  3. Western Medicine Guide Project of Shanghai Committee of Science and Technology [19411966000]

Ask authors/readers for more resources

Inspired by the intrinsic recovery mechanism of efferocytosis, researchers have developed an inhalable nanozyme that promotes apoptotic cell removal and inhibits inflammation, thus alleviating acute lung injury. This nanozyme effectively mimics the signals of apoptotic bodies and scavenges excessive reactive oxygen species, addressing a critical factor in the pathogenesis of sepsis-related ALI.
Acute lung injury (ALI) is a significant contributor to the morbidity and mortality of sepsis. Characterized by uncontrolled inflammation and excessive inflammatory cells infiltration in lung, ALI has been exacerbated by impaired efferocytosis (clearance of apoptotic cells by macrophages). Through specific receptor recognition and activation of downstream signaling, efferocytic macrophages promote resolution of inflammation by efficiently engulfing dying cells, avoiding the consequent release of cellular inflammatory contents. Here, inspired by the intrinsic recovery mechanism of efferocytosis, an apoptotic cell membrane (ACM) coated antioxidant nanozyme (AOzyme) is engineered, thus obtaining an inhalable pro-efferocytic nanozyme (AOzyme@ACM). Notably, AOzyme@ACM can efficiently increase apoptotic cell removal by combing enhanced macrophages recognition of eat me signals through apoptotic body mimicking and scavenge of intracellular excessive reactive oxygen species (ROS), a significant barrier for efferocytosis. AOzyme@ACM can significantly inhibit inflammatory response, promote pro-resolving (M2) phenotype transition of macrophage, and alleviate ALI in endotoxemia mice compared with AOzyme group. By addressing the critical factor in the pathogenesis of sepsis-related ALI through restoring efferocytosis activity, the ACM-based antioxidant nanozyme in this study is envisioned to provide a promising strategy to treat this complex and challenging disease.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.8
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available