Journal
ADVANCED SCIENCE
Volume 9, Issue 28, Pages -Publisher
WILEY
DOI: 10.1002/advs.202202797
Keywords
immunotherapy; nanomaterials; nanomedicines; ovarian cancer; tumor immune microenvironment
Categories
Funding
- National Natural Science Foundation of China, China [81974508, 21974134]
- Hunan Science Fund for Distinguished Young Scholar [2021JJ10067]
- Innovation-Driven Project of Central South University [202045005]
- Hunan Provincial Natural Science Foundation of China [2021JJ31066]
- Key Research Project of Ningxia Hui Autonomous Region [2021BEG01001]
- Key Program of Ningxia Hui Autonomous Region Natural Science Foundation of China [2022JJ21059]
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The article discusses the revolutionizing effects of immunotherapy on cancer treatment and the limitations of immunotherapy on ovarian cancer. Nanomedicines have shown promise in improving ovarian cancer treatment by reversing the cold tumor immune microenvironment.
Immunotherapy has revolutionized cancer treatment, dramatically improving survival rates of melanoma and lung cancer patients. Nevertheless, immunotherapy is almost ineffective against ovarian cancer (OC) due to its cold tumor immune microenvironment (TIM). Many traditional medications aimed at remodeling TIM are often associated with severe systemic toxicity, require frequent dosing, and show only modest clinical efficacy. In recent years, emerging nanomedicines have demonstrated extraordinary immunotherapeutic effects for OC by reversing the TIM because the physical and biochemical features of nanomedicines can all be harnessed to obtain optimal and expected tissue distribution and cellular uptake. However, nanomedicines are far from being widely explored in the field of OC immunotherapy due to the lack of appreciation for the professional barriers of nanomedicine and pathology, limiting the horizons of biomedical researchers and materials scientists. Herein, a typical cold tumor-OC is adopted as a paradigm to introduce the classification of TIM, the TIM characteristics of OC, and the advantages of nanomedicines for immunotherapy. Subsequently, current nanomedicines are comprehensively summarized through five general strategies to substantially enhance the efficacy of immunotherapy by heating the cold OC. Finally, the challenges and perspectives of this expanding field for improved development of clinical applications are also discussed.
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