4.5 Article

Antibacterial Photodynamic Therapy in the Near-Infrared Region with a Targeting Antimicrobial Peptide Connected to a p-Extended Porphyrin

Related references

Note: Only part of the references are listed.
Review Biochemistry & Molecular Biology

Latest trends on photodynamic disinfection of Gram-negative bacteria: photosensitizer's structure and delivery systems

Nidia Maldonado-Carmona et al.

Summary: Antimicrobial resistance poses a threat to medical advances, with multidrug-resistant strains of previously eradicated infectious diseases resurging, particularly among Gram-negative strains. Photodynamic Antimicrobial ChemoTherapy utilizes toxic reactive oxygen species generated in the presence of light, oxygen, and a photosensitizer molecule for disinfection, offering a promising alternative to chemical agents. By harnessing light-driven reactive species, the potential of tolerance to antimicrobial treatment can be reduced, providing a potential solution to combat Gram-negative bacteria.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2022)

Review Chemistry, Multidisciplinary

Recent Strategies to Develop Innovative Photosensitizers for Enhanced Photodynamic Therapy

Thanh Chung Pham et al.

Summary: This review presents a robust strategy for designing photosensitizers for different species, highlighting the importance of organic PSs in photodynamic therapy. While previous studies have focused on nanomaterials and traditional PSs, this review sets out to report recent innovative strategies for developing organic photosensitizers for enhanced PDT, providing detailed examples to offer intuitive and specific insights to readers.

CHEMICAL REVIEWS (2021)

Article Chemistry, Physical

Advances in photodynamic antimicrobial chemotherapy

Abdulaziz Anas et al.

Summary: PACT, utilizing light and photosensitizers, has advanced significantly in treating microbial infections, competing with antibiotics and reducing antibiotic resistance. New light sources, photosensitizers, and applications are constantly evolving, including COVID-19 treatment and disinfection of food and water. PACT demonstrates good pathogen selectivity and treatment efficiency.

JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY C-PHOTOCHEMISTRY REVIEWS (2021)

Review Biochemistry & Molecular Biology

Photodynamic disinfection and its role in controlling infectious diseases

Rafael T. Aroso et al.

Summary: Photodynamic therapy is gaining attention as a response to the shortage of new antibiotics and the increase in drug resistant infections, with a focus on the efficacy of photosensitizers and affordability of light sources to expand applications in managing infectious diseases. Success in the management of infectious diseases using photodynamic therapy will depend on the effectiveness of photosensitizers and availability of efficient treatments.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2021)

Article Biochemistry & Molecular Biology

Photophysical and Bactericidal Properties of Pyridinium and Imidazolium Porphyrins for Photodynamic Antimicrobial Chemotherapy

Florent Le Guern et al.

Summary: The study reports the synthesis and characterization of tetracationic porphyrins from three families, comparing their photophysical properties with a well-known pyridinium porphyrin family. The results show that these new photosensitizers may offer a good alternative, especially against S. aureus and E. coli, and pave the way for new cationic photosensitizers through derivatization.

MOLECULES (2021)

Article Chemistry, Organic

Photosensitizer-peptoid conjugates for photoinactivation of Gram-negative bacteria: structure-activity relationship and mechanistic studies

Woojin Yang et al.

Summary: The study focused on the structure-antimicrobial activity relationships of PsPCs against Escherichia coli, highlighting PsPC 9 as the most promising photoresponsive antimicrobial agent among the synthesized PsPCs. Experimental results demonstrated that PsPC 9 generated singlet oxygen upon absorption of visible light while maintaining the conformation of the peptoid, ultimately exerting bactericidal activity through damaging bacterial membrane and DNA.

ORGANIC & BIOMOLECULAR CHEMISTRY (2021)

Review Engineering, Biomedical

Revealing the Mechanisms of Synergistic Action of Two Magainin Antimicrobial Peptides

Burkhard Bechinger et al.

FRONTIERS IN MEDICAL TECHNOLOGY (2020)

Article Biochemistry & Molecular Biology

Design of photodynamic chitosan hydrogels bearing phthalocyanine-colistin conjugate as an antibacterial agent

Fahimeh Bayat et al.

INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES (2019)

Article Materials Science, Biomaterials

A versatile bacterial membrane-binding chimeric peptide with enhanced photodynamic antimicrobial activity

Ai-Nv Zhang et al.

JOURNAL OF MATERIALS CHEMISTRY B (2019)

Article Chemistry, Medicinal

Lysine Analogue of Polymyxin B as a Significant Opportunity for Photodynamic Antimicrobial Chemotherapy

Florent Le Guern et al.

ACS MEDICINAL CHEMISTRY LETTERS (2018)

Article Chemistry, Multidisciplinary

Conformational control of nonplanar free base porphyrins: towards bifunctional catalysts of tunable basicity

M. Roucan et al.

CHEMICAL COMMUNICATIONS (2018)

Article Chemistry, Medicinal

Rapid Uptake and Photodynamic Inactivation of Staphylococci by Ga(III)-Protoporphyrin IX

Ana V. Morales-de-Echegaray et al.

ACS INFECTIOUS DISEASES (2018)

Article Engineering, Biomedical

Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods

Caerwyn Ash et al.

LASERS IN MEDICAL SCIENCE (2017)

Article Oncology

Optimizing Zn porphyrin-based photosensitizers for efficient antibacterial photodynamic therapy

Khazna Alenezi et al.

PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY (2017)

Article Chemistry, Multidisciplinary

π-extended porphyrin dimers as efficient near-infrared emitters and two-photon absorbers

Julie Schmitt et al.

SUPRAMOLECULAR CHEMISTRY (2017)

Article Biochemical Research Methods

Enhanced Photobactericidal and Targeting Properties of a Cationic Porphyrin following the Attachment of Polymyxin B

Florent Le Guern et al.

BIOCONJUGATE CHEMISTRY (2017)

Article Chemistry, Multidisciplinary

Boronic Acid Functionalized Photosensitizers: A Strategy To Target the Surface of Bacteria and Implement Active Agents in Polymer Coatings

Anzhela Galstyan et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2017)

Article Chemistry, Multidisciplinary

Diketopyrrolopyrrole-Porphyrin Conjugates with High Two-Photon Absorption and Singlet Oxygen Generation for Two-Photon Photodynamic Therapy

Julie Schmitt et al.

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2015)

Review Biochemistry & Molecular Biology

The SMART model: Soft Membranes Adapt and Respond, also Transiently, in the presence of antimicrobial peptides

Burkhard Bechinger

JOURNAL OF PEPTIDE SCIENCE (2015)

Article Polymer Science

Conjugated Polymers: Evaluating DFT Methods for More Accurate Orbital Energy Modeling

Theresa M. McCormick et al.

MACROMOLECULES (2013)

Article Oncology

Photodynamic Therapy of Cancer: An Update

Patrizia Agostinis et al.

CA-A CANCER JOURNAL FOR CLINICIANS (2011)

Review Chemistry, Multidisciplinary

The role of porphyrin chemistry in tumor imaging and photodynamic therapy

Manivannan Ethirajan et al.

CHEMICAL SOCIETY REVIEWS (2011)

Article Biochemistry & Molecular Biology

Effective photoinactivation of Gram-positive and Gram-negative bacterial strains using an HIV-1 Tat peptide-porphyrin conjugate

Ludovic Bourre et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2010)

Review Biochemistry & Molecular Biology

Biological activity and structural aspects of PGLa interaction with membrane mimetic systems

Karl Lohner et al.

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES (2009)

Review Chemistry, Multidisciplinary

Amino Acid-Protecting Groups

Albert Isidro-Llobet et al.

CHEMICAL REVIEWS (2009)

Article Biochemistry & Molecular Biology

Uptake pathways of anionic and cationic photosensitizers into bacteria

Saji George et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2009)

Article Microbiology

Inhibitors of bacterial multidrug efflux pumps potentiate antimicrobial photoinactivation

George P. Tegos et al.

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY (2008)

Article Biochemical Research Methods

HELIQUEST:: a web server to screen sequences with specific α-helical properties

Romain Gautier et al.

BIOINFORMATICS (2008)

Review Biochemistry & Molecular Biology

Photodynamic therapy: a new antimicrobial approach to infectious disease?

MR Hamblin et al.

PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES (2004)

Article Chemistry, Medicinal

Synthesis and antibacterial activity of new poly-S-lysine-porphyrin conjugates

JPC Tomé et al.

JOURNAL OF MEDICINAL CHEMISTRY (2004)