Journal
PEERJ
Volume 10, Issue -, Pages -Publisher
PEERJ INC
DOI: 10.7717/peerj.13901
Keywords
Flotillin-1; Metastasis; EMT; Gastric cancer; Snail
Categories
Funding
- Medical Science Research Project of Hebei Province [20220202]
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In this study, the upregulation of Flotillin-1 in gastric cancer was observed and correlated with a worse prognosis. Overexpression of Flotillin-1 enhanced the migration and invasion ability of gastric cancer cells, while knockdown of Flotillin-1 inhibited metastasis. Flotillin-1 promoted gastric cancer cell metastasis through inducing EMT process.
Gastric cancer is one of the most common malignancies worldwide and has been identified as the third leading cause of cancer-related mortality. Flotillin-1 is a lipid raft-associated scaffolding protein and plays an important role in the progression and development of several malignant carcinomas. Flotillin-1 is involved in epithelial-mesenchymal transition (EMT) process of several solid tumors to promote metastasis. However, the detailed characteristics and mechanisms of Flotillin-1 in gastric cancer have rarely been investigated. In this study, we found Flotillin-1 upregulated in gastric cancer, and the high expression of Flotillin-1 correlated with a worse prognosis. The migration and invasion ability of gastric cancer cells was upregulated by overexpressing Flotillin-1. Knockdown of Flotillin-1 inhibits gastric cancer cells metastasis. Flotillin-1 is a key regulator of EMT process and promotes gastric cancer cells metastasis through inducing EMT. Flotillin-1 may interact with a deubiquitinase to inhibit the ubiquitination of Snail in gastric cancer cells to promote EMT process. Our study provides a rationale and potential target for the treatment of gastric cancer.
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