Journal
NANOMATERIALS
Volume 12, Issue 13, Pages -Publisher
MDPI
DOI: 10.3390/nano12132242
Keywords
magneto-plasmonic nanoparticles; neurodegenerative disease; magnetic field; light stimulation; controlled and sustained drug release; brain organoid
Categories
Funding
- U.S. National Science Foundation [CAREER-1751435, GCR-2021081, GCR-2020867]
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Finding curable therapies for neurodegenerative disease is a global challenge. Researchers have been investigating the development of novel therapeutic techniques, such as using nanocarriers to deliver neuroprotective drugs through magnetic field and light stimulation. Magneto-plasmonic nanoparticles show promise as potential smart nanocarriers for repairing and restoring brain tissues affected by neurodegenerations.
Finding curable therapies for neurodegenerative disease (ND) is still a worldwide medical and clinical challenge. Recently, investigations have been made into the development of novel therapeutic techniques, and examples include the remote stimulation of nanocarriers to deliver neuroprotective drugs, genes, growth factors, and antibodies using a magnetic field and/or low-power lights. Among these potential nanocarriers, magneto-plasmonic nanoparticles possess obvious advantages, such as the functional restoration of ND models, due to their unique nanostructure and physiochemical properties. In this review, we provide an overview of the latest advances in magneto-plasmonic nanoparticles, and the associated therapeutic approaches to repair and restore brain tissues. We have reviewed their potential as smart nanocarriers, including their unique responsivity under remote magnetic and light stimulation for the controlled and sustained drug delivery for reversing neurodegenerations, as well as the utilization of brain organoids in studying the interaction between NPs and neuronal tissue. This review aims to provide a comprehensive summary of the current progress, opportunities, and challenges of using these smart nanocarriers for programmable therapeutics to treat ND, and predict the mechanism and future directions.
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