Journal
NANOMATERIALS
Volume 12, Issue 15, Pages -Publisher
MDPI
DOI: 10.3390/nano12152547
Keywords
fullerene; water-soluble fullerene derivatives; antivirus; nanodrug
Categories
Funding
- National Natural Science Foundation of China (NSFC) [91961113, 21721001, 92061204, 21827801, 92061000]
- Xiamen Youth Innovation Fund [3502Z20206054]
- Funds of the Science and Technology Project of Yunnan Province-Major Project [202101AS070049]
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In this review, we systematically summarize the latest research on fullerenes in antiviral studies. We discuss the unique structural advantage of fullerenes, present diverse modification strategies, evaluate the impact of structural differences on antiviral activity, describe the potential antiviral mechanism, and explore the prospective development of fullerenes as antiviral drugs.
Unlike traditional small molecule drugs, fullerene is an all-carbon nanomolecule with a spherical cage structure. Fullerene exhibits high levels of antiviral activity, inhibiting virus replication in vitro and in vivo. In this review, we systematically summarize the latest research regarding the different types of fullerenes investigated in antiviral studies. We discuss the unique structural advantage of fullerenes, present diverse modification strategies based on the addition of various functional groups, assess the effect of structural differences on antiviral activity, and describe the possible antiviral mechanism. Finally, we discuss the prospective development of fullerenes as antiviral drugs.
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