Journal
MULTIPLE SCLEROSIS AND RELATED DISORDERS
Volume 63, Issue -, Pages -Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.msard.2022.103839
Keywords
Induced pluripotent stem cells (iPSCs); Multiple sclerosis (MS); Oligodendrocytes; Neurons; Microglia; Disease modelling
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Funding
- Medical Research Future Fund [EPCD00008]
- Australian Research Training Program (RTP) Scholarship
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This review summarizes the discoveries made using iPSCs derived from people with MS and explores their current and potential applications in MS research.
Multiple sclerosis (MS) is a complex disease, and its pathophysiology impacts the function of immune and central nervous system cell types. Despite extensive investigation into the aetiology of MS, the underlying cause/s remain elusive and consequently, faithful in vitro or in vivo preclinical models of MS do not exist. Advances human stem cell technologies have enabled the generation of induced pluripotent stem cells (iPSCs) from people with MS. This review summarises the discoveries made using iPSCs derived from people with MS and explores their current and potential application/s in MS research.
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