Journal
GENES
Volume 13, Issue 8, Pages -Publisher
MDPI
DOI: 10.3390/genes13081357
Keywords
BRCA1; BRCA2; breast cancer; risk-reducing mastectomy; BREAST-Q
Categories
Funding
- German Cancer Aid [110837, 70114178]
- Federal Ministry of Education and Research (BMBF), Germany [01GY1901]
- Koln Fortune Program, Faculty of Medicine and University of Cologne, Germany
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This study assessed satisfaction and health-related quality of life after bilateral risk-reducing mastectomy and reconstruction. The results showed that satisfaction and quality of life were dependent on the time of surgery rather than the surgical technique or type of reconstruction. Previvors had higher satisfaction scores in psychosocial, sexual, and physical well-being compared to survivors.
Risk-reducing mastectomy (RRM) is the most efficient form of breast cancer (BC) risk reduction in BRCA1/2 pathogenic variant (pV) carriers. However, this intervention in physical integrity is associated with significant morbidity. We assessed long-term perception of satisfaction and health-related quality of life (QoL) after bilateral RRM and reconstruction using the validated BREAST-Q. We searched the prospective database of the Center for Hereditary Breast and Ovarian Cancer Cologne for previvors and survivors who underwent bilateral RRM from 1994 to 2015 and evaluated the results of their BREAST-Q scores. The study enrolled 43 previvors and 90 survivors after a mean follow-up of 46.3 +/- 45.3 months after RRM. Satisfaction and QoL were independent of the technique of RRM or type of reconstruction but depended on the time of RRM. Compared to survivors, previvors had significantly higher mean satisfaction scores in their psychosocial, sexual, and physical well-being (chest) in both modules. Among previvors and survivors, higher psychological well-being correlated with a higher satisfaction with information and higher satisfaction with outcome. As psychological well-being correlated with satisfaction with information and outcome, we developed decision aids to improve shared decision making and long-term satisfaction with the decision and the postoperative outcome.
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