☆ 4.6 Article

Synergic Effect of Metformin and Everolimus on Mitochondrial Dynamics of Renal Cell Carcinoma

GENES (2022)

Related references

Note: Only part of the references are listed.

Article Oncology

Nivolumab, nivolumab-ipilimumab, and VEGFR-tyrosine kinase inhibitors as first-line treatment for metastatic clear-cell renal cell carcinoma (BIONIKK): a biomarker-driven, open-label, non-comparative, randomised, phase 2 trial

Yann-Alexandre Vano et al.

Summary: This study demonstrated the feasibility and positive impact of prospective patient selection based on tumor molecular phenotype to choose the most effective treatment between nivolumab with or without ipilimumab and a VEGFR-TKI in the first-line treatment of metastatic clear-cell renal cell carcinoma.

LANCET ONCOLOGY (2022)

Add to Collection

Review Oncology

Trial Watch: combination of tyrosine kinase inhibitors (TKIs) and immunotherapy

Adriana Petrazzuolo et al.

Summary: The clinical use of targeted therapies, including tyrosine kinase inhibitors (TKIs), has made significant progress in the past few decades. TKIs can inhibit various pro-tumorigenic signals and have effects on cancer cells, angiogenesis, and hematologic lineage cells. They have been shown to improve immune recognition and cancer immunosurveillance, providing a scientific basis for combining TKIs with immunotherapy. However, further improvement is needed in identifying appropriate drug combinations, optimal dosing, and scheduling to make tangible progress in cancer care.

ONCOIMMUNOLOGY (2022)

Add to Collection

Review Oncology

Mitochondria as a Novel Target for Cancer Chemoprevention: Emergence of Mitochondrial-targeting Agents

Mofei Huang et al.

Summary: Cancer chemoprevention is essential for controlling cancer in the population, and the development of mitochondria-targeted agents shows promise in preventing cancer progression.

CANCER PREVENTION RESEARCH (2021)

Add to Collection

Article Biochemistry & Molecular Biology

Metformin Affects Olaparib Sensitivity through Induction of Apoptosis in Epithelial Ovarian Cancer Cell Lines

Patrycja Gralewska et al.

Summary: This study demonstrated that the combination treatment of olaparib and metformin had a significant inhibitory effect on HR-proficient ovarian cancer cells, inducing apoptosis by increasing ROS levels. The synergistic effect was observed in cells with mutant or null p53, providing a new approach for the treatment of gynecologic cancers. The results support the use of metformin to enhance the sensitivity of EOC to olaparib therapy.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2021)

Add to Collection

Article Oncology

Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries

Hyuna Sung et al.

Summary: The global cancer burden in 2020 saw an estimated 19.3 million new cancer cases and almost 10.0 million cancer deaths. Female breast cancer surpassed lung cancer as the most commonly diagnosed cancer, while lung cancer remained the leading cause of cancer death. These trends are expected to rise in 2040, with transitioning countries experiencing a larger increase compared to transitioned countries due to demographic changes and risk factors associated with globalization and a growing economy. Efforts to improve cancer prevention measures and provision of cancer care in transitioning countries will be crucial for global cancer control.

CA-A CANCER JOURNAL FOR CLINICIANS (2021)

Add to Collection

Article Cell Biology

Mitochondrial Breast Cancer Resistant Protein Sustains the Proliferation and Survival of Drug-Resistant Breast Cancer Cells by Regulating Intracellular Reactive Oxygen Species

He Zhang et al.

Summary: In drug-resistant breast cancer cells, BCRP plays a crucial role in promoting tumor growth and survival by inhibiting oxidative phosphorylation, rather than solely functioning as a drug efflux pump. This study sheds new light on the complex functional role of ABC transporters in drug-resistant cells.

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY (2021)

Add to Collection

Article Oncology

Lenvatinib with or Without Everolimus in Patients with Metastatic Renal Cell Carcinoma After Immune Checkpoint Inhibitors and Vascular Endothelial Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapies

Andrew J. Wiele et al.

Summary: The study retrospectively evaluated the clinical efficacy of Len +/- Eve in heavily pretreated patients with mRCC who had progressed on prior ICIs and VEGFR-TKIs, demonstrating meaningful clinical activity and tolerability. The results support the use of lenvatinib with or without everolimus as a salvage strategy for patients whose disease progresses after treatment with immune checkpoint inhibitors and VEGFR-TKIs.

ONCOLOGIST (2021)

Add to Collection

Review Medicine, Research & Experimental

Mechanism and application of metformin in kidney diseases: An update

Anni Song et al.

Summary: Metformin, an oral antihyperglycemic drug, not only treats type 2 diabetes mellitus but also demonstrates beneficial effects in various kidney diseases by activating AMPK. It protects renal cells from inflammation, apoptosis, and stress, alleviates podocyte loss and fibrosis, and inhibits cyst formation. However, clinical data may not always align with preclinical findings, with some showing minimal or negative effects on T2DM patients with kidney diseases. The issue of metformin-associated lactic acidosis also poses challenges to its application.

BIOMEDICINE & PHARMACOTHERAPY (2021)

Add to Collection

Article Oncology

Drug Repurposing to Identify a Synergistic High-Order Drug Combination to Treat Sunitinib-Resistant Renal Cell Carcinoma

Magdalena Rausch et al.

Summary: Drug combination screening was used to design a multidrug combination for treating sunitinib-resistant clear cell renal cell carcinoma, resulting in significant alterations in gene transcription related to apoptosis and metabolic pathways. The optimized multidrug combination showed strong upregulation of sphingolipids and demonstrated significant anti-cancer efficacy in ex vivo organoid-like cultures. The combination treatment maintained an efficacy of over 70%, indicating a promising mechanism of action for selectively targeting cancer cells in ccRCC.

CANCERS (2021)

Add to Collection

Review Biochemistry & Molecular Biology

The SLC25 Mitochondrial Carrier Family: Structure and Mechanism

Jonathan J. Ruprecht et al.

TRENDS IN BIOCHEMICAL SCIENCES (2020)

Add to Collection

Article Biochemistry & Molecular Biology

Disruption of mitochondrial dynamics increases stress resistance through activation of multiple stress response pathways

Emily Machiela et al.

FASEB JOURNAL (2020)

Add to Collection

Article Oncology

Kidney Cancer, Version 1.2021 Featured Updates to the NCCN Guidelines

Robert J. Motzer et al.

JOURNAL OF THE NATIONAL COMPREHENSIVE CANCER NETWORK (2020)

Add to Collection

Review Biochemistry & Molecular Biology

Current Status and Application of Metformin for Prostate Cancer: A Comprehensive Review

Hyun Kyu Ahn et al.

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES (2020)

Add to Collection

Review Oncology

mTORC1 as a Regulator of Mitochondrial Functions and a Therapeutic Target in Cancer

Karen Griselda de la Cruz Lopez et al.

FRONTIERS IN ONCOLOGY (2019)

Add to Collection

Article Biochemistry & Molecular Biology

Metformin Induces Different Responses in Clear Cell Renal Cell Carcinoma Caki Cell Lines

Mazhar Pasha et al.

BIOMOLECULES (2019)

Add to Collection

Review Oncology

Metformin and cancer: An existing drug for cancer prevention and therapy (Review)

Fuming Zi et al.

ONCOLOGY LETTERS (2018)

Add to Collection

Article Oncology

Phase I Dose-Escalation Trial of PT2385, a First-in-Class Hypoxia-Inducible Factor-2α Antagonist in Patients With Previously Treated Advanced Clear Cell Renal Cell Carcinoma

Kevin D. Courtney et al.

JOURNAL OF CLINICAL ONCOLOGY (2018)

Add to Collection

Article Cell Biology

Metformin reverses prostate cancer resistance to enzalutamide by targeting TGF-β1/STAT3 axis-regulated EMT

Qiuli Liu et al.

CELL DEATH & DISEASE (2017)

Add to Collection

Article Medicine, Research & Experimental

Metformin Induces Growth Inhibition and Cell Cycle Arrest by Upregulating MicroRNA34a in Renal Cancer Cells

Wei Xie et al.

MEDICAL SCIENCE MONITOR (2017)

Add to Collection

Article Urology & Nephrology

Metformin and Prostate Cancer: a New Role for an Old Drug

Jessica Whitburn et al.

CURRENT UROLOGY REPORTS (2017)

Add to Collection

Article Oncology

Effect of Metformin Use on Survival Outcomes in Patients With Metastatic Renal Cell Carcinoma

Lana Hamieh et al.

CLINICAL GENITOURINARY CANCER (2017)

Add to Collection

Article Urology & Nephrology

Renal cell cancer histological subtype distribution differs by race and sex

Loren Lipworth et al.

BJU INTERNATIONAL (2016)

Add to Collection

Article Urology & Nephrology

Metformin-Derived Growth Inhibition in Renal Cell Carcinoma Depends on miR-21-Mediated PTEN Expression

Charis Kalogirou et al.

UROLOGIA INTERNATIONALIS (2016)

Add to Collection

Article Oncology

Metformin Use and Outcome of Sunitinib Treatment in Patients With Diabetes and Metastatic Renal Cell Carcinoma

Daniel Keizman et al.

CLINICAL GENITOURINARY CANCER (2016)

Add to Collection

Article Oncology

Everolimus affects vasculogenic mimicry in renal carcinoma resistant to sunitinib

Maria Serova et al.

ONCOTARGET (2016)

Add to Collection

Article Oncology

Sensitization to oxaliplatin in HCT116 and HT29 cell lines by metformin and ribavirin and differences in response to mitochondrial glutaminase inhibition

Silvina M. Richard et al.

JOURNAL OF CANCER RESEARCH AND THERAPEUTICS (2015)

Add to Collection

Article Medicine, General & Internal

Nivolumab versus Everolimus in Advanced Renal-Cell Carcinoma

R. J. Motzer et al.

NEW ENGLAND JOURNAL OF MEDICINE (2015)

Add to Collection

Article Oncology

Metformin limits the adipocyte tumor-promoting effect on ovarian cancer

Calvin Tebbe et al.

ONCOTARGET (2014)

Add to Collection

Article Biology

Metformin inhibits mitochondrial complex I of cancer cells to reduce tumorigenesis

William W. Wheaton et al.

ELIFE (2014)

Add to Collection

Article Medicine, Research & Experimental

mTOR inhibitor RAD001 (everolimus) induces apoptotic, not autophagic cell death, in human nasopharyngeal carcinoma cells

Yuchen Cai et al.

INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE (2013)

Add to Collection

Review Biochemistry & Molecular Biology

The mitochondrial transporter family SLC25: Identification, properties and physiopathology

Ferdinando Palmieri

MOLECULAR ASPECTS OF MEDICINE (2013)

Add to Collection

Article Multidisciplinary Sciences

Metformin Therapy and Risk of Cancer in Patients with Type 2 Diabetes: Systematic Review

Monica Franciosi et al.

PLOS ONE (2013)

Add to Collection

Article Oncology

Metformin inhibits renal cell carcinoma in vitro and in vivo xenograft

Jun Liu et al.

UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS (2013)

Add to Collection

Article Oncology

Insulin- and Obesity-Related Variables in Early-Stage Breast Cancer: Correlations and Time Course of Prognostic Associations

Pamela J. Goodwin et al.

JOURNAL OF CLINICAL ONCOLOGY (2012)

Add to Collection

Article Urology & Nephrology

Histological Subtype is an Independent Predictor of Outcome for Patients With Renal Cell Carcinoma

Bradley C. Leibovich et al.

JOURNAL OF UROLOGY (2010)

Add to Collection

Article Medicine, General & Internal

Temsirolimus, interferon alfa, or both for advanced renal-cell carcinoma

Gary Hudes et al.

NEW ENGLAND JOURNAL OF MEDICINE (2007)

Add to Collection

Article Biochemical Research Methods

Processing tissue and cells for transmission electron microscopy in diagnostic pathology and research

Lesley Graham et al.

NATURE PROTOCOLS (2007)

Add to Collection

Article Multidisciplinary Sciences

The kinase LKB1 mediates glucose homeostasis in liver and therapeutic effects of metformin

RJ Shaw et al.

SCIENCE (2005)

Add to Collection

Article Biochemistry & Molecular Biology

Identification of the mitochondrial ATP-Mg/Pi transporter -: Bacterial expression, reconstitution, functional characterization, and tissue distribution

G Fiermonte et al.

JOURNAL OF BIOLOGICAL CHEMISTRY (2004)

Add to Collection

© Peeref 2019-2024. All rights reserved.