Human Fetal Liver Parenchyma CD71+Cells Have AIRE and Tissue-Specific Antigen Gene Expression

Autoimmune regulator (AIRE) is a multifunctional protein that is capable of inducing tissue-specific antigens' (TSAs) gene expression, a key event in the induction of self-tolerance, that is usually expressed and functions in the thymus. However, its expression has been detected outside the thymus and cells expressing the gene have been named extra-thymic AIRE expressing cells (eTACs). Here, we discuss the finding of AIRE and TSAs gene expression in CD71+ cells from human fetal liver parenchyma, which are mostly represented by CD71+ erythroid cells.

Automated summary

The expression of AIRE and TSAs genes was found in CD71+ cells, mainly represented by CD71+ erythroid cells, from human fetal liver parenchyma.