Editorial: Insights in exercise physiology: 2021

Summary: Skeletal muscle cells can undergo volume changes during exercise and rest, regulated by different mechanisms for volume decrease and increase. These volume changes can affect the strength of muscle activity and signaling processes, indicating that cell volume may be a regulated variable in skeletal muscle cells. Muscles contracting at moderate to high intensity gain intracellular volume while non-contracting muscles lose cell volume, influenced by changes in osmolality.