Reduning Attenuates LPS-Induced Human Unmilical Vein Endothelial Cells (HUVECs) Apoptosis Through PI3K-AKT Signaling Pathway

Article Medicine, General & Internal

Inhibition of Matrix Metalloproteinase-8 Protects Against Sepsis Serum Mediated Leukocyte Adhesion

Xiao Fang et al.

Summary: This study identified MMP8 as a key gene in the development of sepsis, and found that sepsis serum promotes leukocyte adhesion to HUVECs via MMP8. This suggests that MMP8 might be a potential therapeutic target for sepsis.

FRONTIERS IN MEDICINE (2022)

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Article Respiratory System

The synergistic Reduning and cefmetazole sodium treatment of severe pneumonia is mediated by the AhR-Src-STAT3 pathway

Shanjun Luo et al.

Summary: RDN can synergistically enhance the effect of cefmetazole sodium treatment in severe pneumonia by increasing the expression level of IL-10 mediated through the AhR-Src-STAT3 pathway, driving macrophage polarization, and attenuating the cytokine storm to control inflammation.

JOURNAL OF THORACIC DISEASE (2022)

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Review Anesthesiology

Epidemiology of sepsis and septic shock

Catherine Chiu et al.

Summary: The epidemiology of sepsis and septic shock is challenging to study due to changing diagnostic definitions and a focus on high-income countries in research. Since 1991, the incidence of sepsis has continued to increase globally, with the latest definitions providing better mortality risk assessment. However, there are concerns that the true global burden of sepsis, including in low-income countries, may be underestimated.

CURRENT OPINION IN ANESTHESIOLOGY (2021)

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Article Plant Sciences

Efficacy and safety of ReDuNing injection as a treatment for COVID-19 and its inhibitory effect against SARS-CoV-2

Qinhai Ma et al.

Summary: RDN demonstrates efficacy in relieving clinical symptoms and reducing SARS-CoV-2 infection by regulating inflammatory cytokines, suggesting its potential as a safe and effective treatment for COVID-19.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Critical Care Medicine

The Therapeutic Value of Hydralazine in Reducing Inflammatory Response, Oxidative Stress, and Mortality in Animal Sepsis: Involvement of the PI3K/AKT Pathway

Danillo Menezes dos Santos et al.

Summary: The study suggests that HDZ has the potential to improve clinical outcomes in sepsis by reducing inflammatory response and oxidative stress through the PI3K/Akt pathway. This indicates that HDZ may be a new therapeutic alternative for treating sepsis.

SHOCK (2021)

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Article Plant Sciences

Reduning injection and its effective constituent luteoloside protect against sepsis partly via inhibition of HMGB1/TLR4/NF-κB/MAPKs signaling pathways

Zheng Wang et al.

Summary: The study demonstrated that Reduning injection (RDN) and its effective constituent luteoloside showed significant protective effects against sepsis, suggesting they may be potential candidate drugs for sepsis treatment. The mechanism of action partially involved the inhibition of HMGB1/TLR4/NF-kappa B/MAPK signaling pathways.

JOURNAL OF ETHNOPHARMACOLOGY (2021)

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Article Plant Sciences

Network pharmacology to explore the anti-inflammatory mechanism of Xuebijing in the treatment of sepsis

Wuai Zhou et al.

Summary: The study utilized network pharmacology to elucidate the mechanism of action of Xuebijing (XBJ) for treating sepsis, identifying four key biological functional modules including inflammation, immune, cell apoptosis, and coagulation. By integrating computational prediction, experimental validation, and literature reported clinical results analysis, the study revealed that XBJ exerts anti-inflammatory effects through regulating the NFκB signaling pathway.

PHYTOMEDICINE (2021)

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Review Medicine, General & Internal

Sepsis-Pathophysiology and Therapeutic Concepts

Dominik Jarczak et al.

Summary: Sepsis is a life-threatening global disease burden, with current treatment mainly relying on basic measures and limited effectiveness of adjuvant therapy. Therefore, a deeper understanding of sepsis immunopathophysiology is needed to explore more promising therapeutic approaches.

FRONTIERS IN MEDICINE (2021)

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Article Pharmacology & Pharmacy

Protective effect of cynaroside on sepsis-induced multiple organ injury through Nrf2/HO-1-dependent macrophage polarization

Jiafan Feng et al.

Summary: Cynaroside demonstrates protective effects against sepsis by alleviating inflammatory response and multi-organ injury, mainly through modulating macrophage polarization balance.

EUROPEAN JOURNAL OF PHARMACOLOGY (2021)

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Article Plant Sciences

Re-Du-Ning injection ameliorates LPS-induced lung injury through inhibiting neutrophil extracellular traps formation

Chenxi Yang et al.

Summary: The study found that Re-Du-Ning injection (RDN) can alleviate LPS-induced acute lung injury (ALI) by inhibiting the MAPK pathway to reduce the formation of neutrophil extracellular traps (NETs).

PHYTOMEDICINE (2021)

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Article Medicine, General & Internal

ICU-Mortality in Old and Very Old Patients Suffering From Sepsis and Septic Shock

Raphael Romano Bruno et al.

Summary: This study compared the mortality, rates of organ support, and length of stay in old and very old intensive care patients with sepsis and septic shock. Very old patients had slightly higher ICU mortality rates, but the clinical relevance of these differences seems to be negligible despite statistical significance.

FRONTIERS IN MEDICINE (2021)

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Article Critical Care Medicine

Sepsis is associated with mitochondrial DNA damage and a reduced mitochondrial mass in the kidney of patients with sepsis-AKI

Elisabeth C. van der Slikke et al.

Summary: Sepsis-associated AKI patients exhibit mitochondrial DNA damage in the kidney, without an upregulation of mitochondrial quality control mechanisms, resulting in reduced mitochondrial mass.

CRITICAL CARE (2021)

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Article Urology & Nephrology