Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.919230
Keywords
Spatholobus suberectus DUNN; atopic dermatitis; NC; Nga mice; HaCaT cells; proinflammatory chemokines
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Funding
- Korea Institute of Oriental Medicine, Ministry of Education, Science and Technology, Republic of Korea [KSN2021330]
- National Research Council of Science & Technology (NST), Republic of Korea [KSN2021330] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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The water extract of S. suberectus Dunn (SSWex) has therapeutic effects for atopic dermatitis (AD), alleviating AD-like symptoms, inhibiting immune cell infiltration, and reducing levels of proinflammatory chemokines.
S. patholobus suberectus Dunn, a traditional Chinese herbal medicine, has various pharmacological activities, such as anti-inflammatory properties. However, to the best of our knowledge, its therapeutic effect on atopic dermatitis (AD) has not been investigated. In this study, we explored the effect of S. suberectus Dunn water extract (SSWex) on AD in vivo and in vitro. In Dermatophagoides farina extract (DfE)-treated NC/Nga mice, the oral administration of SSWex alleviated AD-like symptoms, such as ear thickness, dermatitis score, epidermal thickness, immune cell infiltration, and levels of AD-related serum parameters (immunoglobulin E, histamine, and proinflammatory chemokines). In HaCaT cells, the production of proinflammatory chemokines induced by interferon-gamma (IFN-gamma) and tumor necrosis factor-alpha (TNF-alpha) was inhibited by SSWex pretreatment. SSWex treatment inhibited the phosphorylation of mitogen-activated protein kinase and activation and translocation of transcriptional factors, such as signal transducer and activator of transcription 1 and nuclear factor kappa B in IFN-gamma/TNF-alpha-stimulated HaCaT cells. These results indicate that SSWex may be developed as an efficient therapeutic agent for AD.
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