New Drugs for Hepatic Fibrosis

The morbidity and mortality of hepatic fibrosis caused by various etiologies are high worldwide, and the trend is increasing annually. At present, there is no effective method to cure hepatic fibrosis except liver transplantation, and its serious complications threaten the health of patients and cause serious medical burdens. Additionally, there is no specific drug for the treatment of hepatic fibrosis, and many drugs with anti-hepatic fibrosis effects are in the research and development stage. Recently, remarkable progress has been made in the research and development of anti-hepatic fibrosis drugs targeting different targets. We searched websites such as PubMed, ScienceDirect, and and found approximately 120 drugs with anti-fibrosis properties, some of which are in phase II or III clinical trials. Additionally, although these drugs are effective against hepatic fibrosis in animal models, most clinical trials have shown poor results, mainly because animal models do not capture the complexity of human hepatic fibrosis. Besides, the effect of natural products on hepatic fibrosis has not been widely recognized at home and abroad. Furthermore, drugs targeting a single anti-hepatic fibrosis target are prone to adverse reactions. Therefore, currently, the treatment of hepatic fibrosis requires a combination of drugs that target multiple targets. Ten new drugs with potential for development against hepatic fibrosis were selected and highlighted in this mini-review, which provides a reference for clinical drug use.

Automated summary

Hepatic fibrosis caused by various etiologies is a high worldwide burden with no effective cure except for liver transplantation. Recent research has shown significant progress in developing drugs targeting different targets for the treatment of hepatic fibrosis. However, many clinical trials have shown poor results, and the potential of natural products in treating hepatic fibrosis is still not widely recognized. Combination therapy targeting multiple targets may be the current approach for treating hepatic fibrosis.