Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.926901
Keywords
network pharmacology COVID-19; mechanism of action; traditional Chinese medicine pharmacology; review
Categories
Funding
- National Famous TCM Inheritance Studio Construction Project of the State Administration of Traditional Chinese Medicine [119]
- National Traditional Chinese Medicine Expert Inheritance Studio Project of the State Administration of Traditional Chinese Medicine [20]
- National Administration of Traditional Chinese Medicine
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Network pharmacology, based on holistic analysis of biological systems, has become a popular tool in traditional Chinese medicine research. It provides a new approach for studying complex TCM systems and has been widely used in explaining TCM treatment mechanisms, drug repositioning, and interpretation of TCM prescriptions, promoting the modernization of TCM. However, there are still shortcomings such as lack of experimental verification and regular updating of the TCM pharmacology network.
Network pharmacology was rapidly developed based on multidisciplinary holistic analysis of biological systems, which has become a popular tool in traditional Chinese medicine (TCM) research in recent years. Its characteristics of integrity and systematization provide a new approach for the study on complex TCM systems, which has many similarities with the holistic concept of TCM. It has been widely used to explain the mechanism of TCM treatment of diseases, drug repositioning, and interpretation of compatibility of TCM prescriptions, to promote the modernization of TCM. The use of TCM have provided crucial support on prevention and treatment of diseases such as the famous three medicines and three prescriptions . Furthermore, TCM has become an important part of the treatment of COVID-19 and is one of the main contents of the Chinese plan to fight the epidemic. The current review demonstrated the role of TCM in treating diseases with multiple components, multiple targets, and multiple pathways, interprets the connotation of TCM treatment method selection based on pathogenesis and also discusses the application of network pharmacology in the study of COVID-19 treatment in TCM including single drug and prescription. However, there are still some shortcomings such as the lack of experimental verification and regular upgrading of the TCM pharmacology network. Therefore, we must pay attention to the characteristics of TCM and develop a network pharmacology method suitable for TCM system research when applying network pharmacology to TCM research.
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