Journal
FRONTIERS IN PHARMACOLOGY
Volume 13, Issue -, Pages -Publisher
FRONTIERS MEDIA SA
DOI: 10.3389/fphar.2022.861319
Keywords
vascular smooth muscle cells; neointima formation; phenotypic switching; TF3; PDGFR beta signaling pathway
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Funding
- National Natural Science Foundation of China [91949201, 81830014]
- Natural Science Foundation of Hubei Province [2020CFB429]
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Theaflavin-3,3'-digallate (TF3) in black tea has a remarkable effect in suppressing neointima formation and regulating the proliferation and migration of vascular smooth muscle cells (VSMCs). It may serve as a potential therapeutic candidate for excessive phenotypic switching of VSMCs.
The abnormal neointima formation caused by the phenotypic switching of vascular smooth cells (VSMCs) into a synthetic state plays a key role in the pathogenesis of various vascular diseases, including atherosclerosis and postangioplasty restenosis. Theaflavin-3,3 & PRIME;-digallate (TF3) in black tea has been reported to exert antiinflammatory and anticancer effects, but its role in neointima formation remains unclear. Here, we delineated a remarkable effect of TF3 in suppressing neointima formation of VSMCs in vivo as well as the ability of primary rat aortic smooth cells (RASMCs) to proliferate and migrate in vitro. Further study confirmed that the effects of TF3 on PDGF-BB-induced RASMCs were due to reduced phosphorylation of PDGFR beta, which led to the repression of downstream pathways. We concluded that TF3 may act as a repressor in the progression of neointima formation and serve as a potential therapeutic candidate for excessive phenotypic switching of VSMCs.
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