Lipid-Lowering Effects of Carob Extracts (Ceratonia siliqua): Proposed Mechanisms and Clinical Importance

The global prevalence of dyslipidemia (elevated plasma levels of total cholesterol, LDL-Cholesterol, triglycerides, and lower plasma levels of HDL-Cholesterol) is constantly on the rise. Lately, carob pulp has been recognized as an effective natural product for the treatment of dyslipidemia. The two main components of the carob pulp, polyphenols, and insoluble fiber are believed to have beneficial effects on lipid metabolism. Studies on humans and animals confirmed its lipid-lowering effects. Several mechanisms have been proposed to explain this phenomenon, namely by affecting three organ systems: 1) gastrointestinal tract, 2) liver and 3) adipose tissue. Also, carob products have antioxidative, anti-inflammatory, and vascular-protective activity.

Automated summary

Carob pulp has been recognized as an effective natural product for the treatment of dyslipidemia due to its beneficial effects on lipid metabolism. Its main components, polyphenols and insoluble fiber, have been found to lower lipid levels and potentially affect the gastrointestinal tract, liver, and adipose tissue. Additionally, carob products exhibit antioxidative, anti-inflammatory, and vascular-protective activity.