Therapeutic Potential of Triptolide in Treating Bone-Related Disorders

Triptolide, a diterpene triepoxide, is a pharmacologically active compound isolated from a Chinese medicinal herb Tripterygium wilfordii Hook F (TwHF). Triptolide has attracted considerable attention in recent times due to its multiple biological and pharmaceutical activities, with an emphasis on therapeutic importance in the treatment of diverse disorders. With essential medicinal implications, TwHF's extracts have been used as anti-inflammatory, antiproliferative, antioxidative, and immunosuppressive agents for centuries, with continuous and relevant modifications to date to enhance its utility in several diseases and pathophysiology. Here, in this review, we accentuate the studies, highlighting the effects of triptolide on treating bone-related disorders, both inflammatory and cancerous, particularly osteosarcoma, and their manifestations. Based on this review, future avenues could be estimated for potential research strategies, molecular mechanisms, and outcomes that might contribute toward reinforcing new dimensions in the clinical application of triptolide in treating bone-related disorders.

Automated summary

This review emphasizes the therapeutic potential of Triptolide, a compound extracted from the Chinese medicinal herb Tripterygium wilfordii Hook F, in treating bone-related disorders, including inflammatory and cancerous bone tumors. The extracts of Tripterygium wilfordii Hook F have been used for centuries as anti-inflammatory, antiproliferative, antioxidative, and immunosuppressive agents, and continuous research and modifications have been made to enhance their utility in various diseases and pathophysiology.